Results 41 to 50 of about 439,676 (282)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Cost-effectiveness of primary offer of IVF vs. primary offer of IUI followed by IVF (for IUI failures) in couples with unexplained or mild male factor subfertility

BMC Health Services Research, 2006
Background In unexplained and mild male factor subfertility, both intrauterine insemination (IUI) and in-vitro fertilisation (IVF) are indicated as first line treatments.
Lyratzopoulos Georgios, Pashayan Nora, Mathur Raj   +2 more
doaj   +1 more source

Could Have, Should Have, Would Have. The Speaker’s Attitude in Expressing Hypothetical Past Alternatives in English and Italian by Means of Pragmatic Markers and Modality in EU Parliamentary Debates. [PDF]

Studies About Languages, 2018
Legislation and important decisions affecting the lives of over 400 million European citizens are discussed on a regular basis in the European Parliament debates. This research paper analyzes the MEPs’ speeches in terms of the co-occurrence of past conditionals and pragmatic markers signalling the speaker’s attitude to the propositional meaning ...
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Crisis futurities in pathogen-responder relations in Kenya: A genealogical approach

Journal of Critical Public Health
Constructing a genealogy of pathogen-responder relations, I reveal how pathogens register in complex ecosystems of human intervention. I illustrate how a grouping of pathogens orients the sensibilities of scientists toward calamity and dystopia through ...
Robert Lorway
doaj   +1 more source

STRATEGIC AND ECONOMIC MODALITY OF ENVIRONMENTAL DIPLOMACY

Вісник Київського національного університету імені Тараса Шевченка. Серія Економіка, 2018
Modern development of humanity and its well-being is measured by the parameters of progressive achievements, global resonance and ecological warnings.
А. Bokhan
doaj   +1 more source

Cost-effective analysis of preliminary single-operator cholangioscopy for management of difficult biliary stones

Endoscopy International Open, 2022
Background and study aims Single-operator peroral cholangioscopy (SOC) is a therapeutic modality for difficult biliary stone disease. Given its high success rate and increasing availability, analysis of the economic impact of early SOC utilization is ...
Igor Sljivic, Roberto Trasolini, Fergal Donnellan   +2 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source