Results 61 to 70 of about 300,381 (385)

Hypothyroidism in the older population

Thyroid Research, 2019
BackgroundBoth overt hypothyroidism as well as minor elevations of serum thyrotropin (TSH) levels associated with thyroid hormones within their respective reference ranges (termed subclinical hypothyroidism) are relatively common in older individuals ...
O. Leng, S. Razvi
semanticscholar   +1 more source

Study protocol; thyroid hormone replacement for untreated older adults with subclinical hypothyroidism - a randomised placebo controlled trial (TRUST) [PDF]

, 2017
Background: Subclinical hypothyroidism (SCH) is a common condition in elderly people, defined as elevated serum thyroid-stimulating hormone (TSH) with normal circulating free thyroxine (fT4).
Bauer, Douglas, Blum, Manuel, Browne, John, Byrne, Stephen, Collet, Tinh-Hai, Dekkers, Olaf M., Den Elzen, Wendy P.J., Du Puy, Robert, Ford, Ian, Gussekloo, Jacobijn, Hendry, Kirsty, Hurley, Caroline, Jukema, J. Wouter, Kean, Sharon, Kearney, Patricia M., McCarthy, Vera, Mooijaart, Simon, Poortvliet, Rosalinde K.E., Quinn, Terence J., Rodondi, Nicolas, Sattar, Naveed, Smit, Jan W.A., Stott, David J., Watt, Torquil, Westendorp, Rudi G.J.   +24 more
core   +9 more sources

Association Between Levothyroxine Treatment and Thyroid-Related Symptoms Among Adults Aged 80 Years and Older With Subclinical Hypothyroidism.

Journal of the American Medical Association (JAMA), 2019
Importance It is unclear whether levothyroxine treatment provides clinically important benefits in adults aged 80 years and older with subclinical hypothyroidism.
S. Mooijaart, R. Puy, D. Stott, P. Kearney, N. Rodondi, R. Westendorp, W. Elzen, I. Postmus, R. Poortvliet, D. Heemst, Barbara C. van Munster, R. Peeters, I. Ford, S. Kean, C. Messow, M. Blum, M. Blum, T. Collet, T. Watt, O. Dekkers, J. Jukema, J. A. Smit, P. Langhorne, J. Gussekloo   +23 more
semanticscholar   +1 more source

Thyroid stimulating hormone (TSH) ≥2.5mU/l in early pregnancy: prevalence and subsequent outcomes [PDF]

, 2017
Objective: There remains controversy over how women with abnormal thyroid function tests in pregnancy should be classified. In this study we assessed the proportion of women with thyroid stimulating hormone (TSH) ≥ 2.5 mU/l in a large obstetric cohort,
Carty, David M., Delles, Christian, Dominiczak, Anna F., Doogan, Flora, Welsh, Paul   +4 more
core   +1 more source

Hypothyroidism and the Heart.

Methodist DeBakey Cardiovascular Journal, 2017
Hypothyroidism is a commonly encountered clinical condition with variable prevalence. It has profound effects on cardiac function that can impact cardiac contractility, vascular resistance, blood pressure, and heart rhythm.
Maja Udovcic, R. H. Pena, B. Patham, L. Tabatabai, Abhishek Kansara   +4 more
semanticscholar   +1 more source

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

Molecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé, Lisa Hahnefeld, Katharina J. Wenger, Donat Kögel, Joachim Steinbach, Gerd Geisslinger, Michael W. Ronellenfitsch, Irmgard Tegeder   +7 more
wiley   +1 more source

Intrauterine Zn deficiency favors thyrotropin-releasing hormone-increasing effects on thyrotropin serum levels and induces subclinical hypothyroidism in weaned rats [PDF]

, 2017
Individuals who consume a diet deficient in zinc (Zn-deficient) develop alterations in hypothalamic-pituitary-thyroid axis function, i.e., a low metabolic rate and cold insensitivity.
Alcántara-Alonso, Viridiana, Alvarez-Salas, Elena, De Gortari, Patricia, Matamoros-Trejo, Gilberto   +3 more
core   +2 more sources

Prevalence of Oral Lichen Planus in Patients with Hypothyroidism Versus Nonhypothyroidism

Journal of Pharmacy and Bioallied Sciences
Background: A chronic inflammatory illness known as oral lichen planus (OLP) affects approximately 1–2% of adults, with middle-aged women having a higher prevalence than men.
Priyanka Vinod Bansal, Kavita Raj, Neha Gupta, Dhara Dwivedi, Ashish Sethi, Nitin Prabhakar, Ramanpal Singh Makkad   +6 more
doaj   +1 more source

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source

Study protocol: a randomised controlled trial on the clinical effects of levothyroxine treatment for subclinical hypothyroidism in people aged 80 years and over [PDF]

, 2018
Background: Subclinical hypothyroidism is common in older people and its contribution to health and disease needs to be elucidated further. Observational and clinical trial data on the clinical effects of subclinical hypothyroidism in persons aged 80 ...
Blum, M.R., Dekkers, O.M., Den Elzen, W.P.J., Du Puy, R.S., Ford, I., Gussekloo, J., Jukema, J.W., Kean, S., Kearney, P.M., Messow, C.M., Mooijaart, S.P., Peeters, R.P., Poortvliet, R.K.E., Postmus, I., Rodondi, N., Smit, J.W.A., Stott, D.J., van Munster, B.C., Watt, T., Westendorp, R.G.J., Wolffenbuttel, B.H.R.   +20 more
core   +8 more sources