Results 41 to 50 of about 36,981 (262)

Navigating adverse immunostimulation: A practical guide for clinical researchers

British Journal of Clinical Pharmacology, EarlyView.
Problem Setting As drug development moves towards more complex products, early clinical development programmes are increasingly hampered by unwanted and/or unexpected activation of the immune system (adverse immune stimulation, AIS). Solution At the Centre for Human Drug Research, we have introduced standardized procedures to make AIS manageable, while
Juliette A. van den Noort, Anouk C. Meijs, Naomi B. Klarenbeek, Matthijs Moerland   +3 more
wiley   +1 more source

Metformin, Sulfonylureas, or Other Antidiabetes Drugs and the Risk of Lactic Acidosis or Hypoglycemia [PDF]

, 2011
OBJECTIVE: Lactic acidosis has been associated with use of metformin. Hypoglycemia is a major concern using sulfonylureas. The aim of this study was to compare the risk of lactic acidosis and hypoglycemia among patients with type 2 diabetes using oral ...
Bodmer, Michael, Jick, Susan S., Krähenbühl, Stephan, Meier, Christian, Meier, Christoph R.   +4 more
core   +2 more sources

Analysis of the usefulness and benefits of ultrafiltration in cardiorenal syndrome: A systematic review

ESC Heart Failure, Volume 12, Issue 2, Page 1194-1202, April 2025.
Abstract Aims Cardiac decompensation in cardiorenal syndrome (CRS) results in systemic congestion usually treated with diuretics. When despite high doses of diuretics, response is poor, ultrafiltration (UF) appears to be a useful and safe technique.
Borja Guerrero Cervera, Raquel López‐Vilella, Víctor Donoso Trenado, María Peris‐Fernández, Paula Carmona, Amparo Soldevila, Sergi Tormo, Ramón Devesa, María Jesús Montero Hernández, Luis Martínez Dolz, Julio Hernández Jaras, Pilar Sánchez‐Pérez, Luis Almenar‐Bonet   +12 more
wiley   +1 more source

Case Report: Presumed cerebral salt wasting syndrome in a 10-week-old German Shorthaired Pointer

Frontiers in Veterinary Science
This case report describes a rare presentation of cerebral salt-wasting syndrome (CSW) in a 10-week-old German Shorthaired Pointer following a traumatic brain injury.
Elizabeth Jackson, Gilad Fefer, Karen R. Muñana, Bernie D. Hansen   +3 more
doaj   +1 more source

Verification and Validation of Lower Body Negative Pressure as a Non-Invasive Bioengineering Tool for Testing Technologies for Monitoring Human Hemorrhage

Bioengineering, 2023
Since hemorrhage is a leading cause of preventable death in both civilian and military settings, the development of advanced decision support monitoring capabilities is necessary to promote improved clinical outcomes. The emergence of lower body negative
Victor A. Convertino, Eric J. Snider, Sofia I. Hernandez-Torres, James P. Collier, Samantha K. Eaton, David R. Holmes, Clifton R. Haider, Jose Salinas   +7 more
doaj   +1 more source

Determining predictors of underlying etiology and clinical deterioration in patients with physiologic instability in the emergency department [PDF]

, 2013
Thesis (M.A.)--Boston UniversityShock is a critical state defined by inadequate oxygen delivery to tissues. It is well known in the critical care community that early diagnosis and treatment of shock are crucial to improving patient outcomes. However, in
Day, Danielle E.
core   +1 more source

Infections Complicating Orthotopic Liver Transplantation: A Study Emphasizing Graft-Related Septicemia [PDF]

, 1976
In 93 recipients of 102 orthotopic liver homografts, the incidence of bacteremia or fungemia exceeded 70%. The graft itself was usually an entry site for systemic infection after both immunologic and nonimmunologic parenchymal injury, especially if there
Hansbrough, JF, Hoelscher, M, Porter, KA, Putnam, CW, Schröter, GPJ, Starzl, TE   +5 more
core   +1 more source

Spontaneous hemoperitoneum in a 29‐week pregnancy with a history of endometriosis: A case report and review of the literature

International Journal of Gynecology &Obstetrics, Volume 169, Issue 1, Page 31-37, April 2025.
Abstract Spontaneous hemoperitoneum in pregnancy (SHIP) is defined as sudden, nontraumatic intraperitoneal bleeding that occurs during pregnancy or up to 42 days postpartum. The incidence ranges between 4 and 4.9 per 100 000 births. Although seen rarely, it is associated with perinatal morbidity and mortality due to maternal hemodynamic instability ...
Shamsi Mehdiyev, Fatma Basak Tanoglu, Esma Demir Altuncu, Engin Oral   +3 more
wiley   +1 more source

Effect of Perftoran on Membrane Nanostructure of Discocyte and Stomatocyte after Acute Blood Loss

Общая реаниматология, 2017
The purpose of the study: to evaluate the effect of Perftoran (PF) on the membrane nanostructure of discocytes and stomatocytes after acute blood loss. Materials and methods. The study was performed in white male rats.
V. V. Moroz, I. S. Novoderzhkina, A. V. Afanasyev, Yu. V. Zarzhetsky, I. A. Ryzhkov, E. K. Kozlova, A. M. Chernysh   +6 more
doaj   +1 more source

The value of inferior vena cava ultrasonography administration for hypovolemia detection in patients with acute kidney injury hospitalized in intensive care unit

Advanced Biomedical Research, 2023
Background: The hypo-perfusion of the kidneys can lead to impairment in renal function and induce renal injury in case of delayed diagnosis and treatment. To date, laboratory markers are routinely used to determine the fluid volume status of the patients.
Saeed Abbasi, Kourosh Nemati, Babak Alikiaii, Mahmood Saghaei   +3 more
doaj   +1 more source