Results 241 to 250 of about 17,899 (259)
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Effects of acyclovir and its metabolites on hypoxanthine-guanine phosphoribosyltransferase
Biochemical Pharmacology, 1983Acyclovir [9-(2-hydroxyethoxymethyl)guanine], a clinically useful anti-herpesvirus agent, was a weak inhibitor (Ki = 190 microM) of hypoxanthine-guanine phosphoribosyltransferase (HGPRTase) from human erythrocytes. Nevertheless, this acyclic nucleoside analog was a more effective inhibitor than were its natural counterparts, guanosine (Ki = 1400 microM)
Joel Van Tuttle +2 more
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New England Journal of Medicine, 1968
Although allopurinol appears to decrease the rate of de novo purine biosynthesis, this effect is variable in gout, possibly because uric acid production is increased in patients who are relatively deficient in hypoxanthine-guanine ...
W. Kelley +3 more
semanticscholar +1 more source
Although allopurinol appears to decrease the rate of de novo purine biosynthesis, this effect is variable in gout, possibly because uric acid production is increased in patients who are relatively deficient in hypoxanthine-guanine ...
W. Kelley +3 more
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Human Hypoxanthine-Guanine Phosphoribosyltransferase (HGPRT): Purification and Properties
1974Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) (E.C. 2.4.2.8.) catalyzes the formation of guanosine-5’-monophosphate and inosine-5’-monophosphate from 5’-phosphoribosyl-l-pyrophosphate (PPribose-P) and the purine bases guanine and hypoxanthine, respectively.
William J. Arnold +2 more
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Electrophoretic Variation in Partial Deficiencies of Hypoxanthine-Guanine Phosphoribosyltransferase
1977In the study of inherited abnormalities of man the demonstration of variable properties of the assayable gene products have provided evidence for structural gene mutations. Different variants from the normal have suggested heterogeneity of these mutations.
Irving H. Fox +3 more
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1974
Partial deficiency of HGPRT, a salvage enzyme of purine metabolism, has been demonstrated to be the primary abnormality causing purine overproduction in a small proportion of patients with gout (1–4). The quantitative deviation in the activity of this enzyme has been shown by Kelley et al.
A. de Vries, Oded Sperling, P. Boer
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Partial deficiency of HGPRT, a salvage enzyme of purine metabolism, has been demonstrated to be the primary abnormality causing purine overproduction in a small proportion of patients with gout (1–4). The quantitative deviation in the activity of this enzyme has been shown by Kelley et al.
A. de Vries, Oded Sperling, P. Boer
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Kinetic Studies of Hypoxanthine-Guanine Phosphoribosyltransferase in Intact Cells
1984Since the discovery that a deficiency of the enzyme hypoxanthine guanine phosphoribosyl transferase (HPRT) was responsible for the Lesch-Nyhan syndrome (1,2) and other related ailments of greatly differing severity (3-5), enzyme assays using tissue lysates have failed to demonstrate a correlation between the degree of the enzyme deficiency and the ...
Theodore Page +2 more
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Biochemical and Biophysical Research Communications, 1967
J. Frank Henderson +3 more
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J. Frank Henderson +3 more
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Clinica chimica acta; international journal of clinical chemistry, 2015
E. Košťálová +4 more
semanticscholar +1 more source
E. Košťálová +4 more
semanticscholar +1 more source
Nucleosides, Nucleotides & Nucleic Acids, 2014
Yasukazu Yamada +13 more
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Yasukazu Yamada +13 more
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