Results 51 to 60 of about 530 (169)

Insights Into the Biological Mechanisms and Multifunctional Health Benefits of Morelloflavone

eFood, Volume 7, Issue 4, August 2026.
Morelloflavone (MF), a biflavonoid from Garcinia and related species, exhibits broad human health benefits through antioxidant, anti‐inflammatory, anticancer, and metabolic regulatory effects. This review highlights its molecular mechanisms, biosynthesis, and emerging roles in chronic disease prevention, emphasizing systems biology and machine learning
Yi Liu, Ziyong Mao, Jesus Simal‐Gandara, Zi Chen, Hui Cao   +4 more
wiley   +1 more source

Abnormalities of neural stem cells in Lesch-Nyhan disease. [PDF]

J Neurogenet, 2022
Dinasarapu AR, Sutcliffe DJ, Seifar F, Visser JE, Jinnah HA.   +4 more
europepmc   +1 more source

Isobavachin Attenuates Renal and Cardiac Injury in Chronic Hyperuricemia via Modulation of NF‐κB and NLRP3 Signaling Pathways

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
Isobavachin alleviates HUA‐induced oxidative stress, inflammation, and fibrosis in the kidney and heart, potentially through its dual role in promoting UA excretion and inhibiting NF‐κB signaling and NLRP3 inflammasome activation. ABSTRACT Hyperuricaemia (HUA) is a recognized risk factor for cardiovascular and renal diseases.
Yongmei Li, Yuexin Xu, Wenjie Ye, Zeqi Yu, Zhenkun Wu, Xinyi Liu, Xuhong Huang, Jianxin Pang, Zean Zhao, Ting Wu   +9 more
wiley   +1 more source

De novo or Salvage? Nucleotide Availability as a Driver of Bacterial Adaptation and Virulence

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
Bacterial pathogens survive in different host environments by switching between making nucleotides by de novo synthesis and scavenging them from the host. This flexibility supports growth and virulence making nucleotide metabolism an attractive therapeutic target.
Riya Joshi, Alastair G. McEwan, Ulrike Kappler   +2 more
wiley   +1 more source

High-risk genotypes for type 1 diabetes are associated with the imbalance of gut microbiome and serum metabolites. [PDF]

Front Immunol, 2022
Yue T, Tan H, Wang C, Liu Z, Yang D, Ding Y, Xu W, Yan J, Zheng X, Weng J, Luo S.   +10 more
europepmc   +1 more source

Microdetermination of hypoxanthine and xanthine [PDF]

Biochemical Journal, 1939
H A, Krebs, A, Orström
openaire   +2 more sources

Nucleotide Metabolism in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Nucleotide metabolism, including de novo synthesis, salvage pathways, and catabolism, when dysregulated contributes to cancer, immune disorders, metabolic and urological diseases, and radiation injury. Metabolites such as adenosine, cGAMP, NAD, and cAMP and enzymes like RNR are promising therapeutic targets and biomarkers.
Xiaoying Zhao, Yiyu Zeng, Yike Xu, Shu Rao, Mouna Khouchani, Hassna Soummane, Jingyi Li, Rui Liu   +7 more
wiley   +1 more source

Chemical Profiling and In Vitro Assessment of Antioxidant and Antimicrobial Properties of Algerian Erica arborea L. Extracts, Strengthened by Molecular Modeling Analysis

ChemistryOpen, Volume 15, Issue 8, August 2026.
Erica arborea L. from Algeria was valorized via chemical profiling and bioactivity assessment. The EtOAc extract showed the highest levels of polyphenols, flavonoids, and flavonols. It exhibited strong antioxidant (ABTS•+, DPPH•, FRAP) and antibacterial activity (S. aureus, B. subtilis).
Amina Bramki, Ouided Benslama, Fatima Zohra Makhlouf, Anna Andolfi, Zineb Mokhbi, Selsabile Nedjaoum, Chawki Bensouici, Maria Michela Salvatore, Marco Masi   +8 more
wiley   +1 more source

Mutation of OsSAC3, Encoding the Xanthine Dehydrogenase, Caused Early Senescence in Rice. [PDF]

Int J Mol Sci, 2022
Xie Z, Zhao B, Zhang M, Sang X, Zhao F, Feng P, He G, Zhu X.   +7 more
europepmc   +1 more source

Metabolic Signatures of Aging and Gametogenesis in Hydra oligactis

Aging Cell, Volume 25, Issue 8, August 2026.
Hydra oligactis undergoes cold‐induced sexual differentiation and aging, culminating in death. GC–MS‐based metabolite profiling revealed signatures of gametogenesis, for example, polyamine accumulation, and of aging, such as loss of cytoprotection and neurotransmitter function, including taurine depletion.
Nicki Marami‐Zonouz, Erwann Arc, Thomas Roach, Pidder Jansen‐Dürr, Werner Bader, Bert Hobmayer, Ilse Kranner   +6 more
wiley   +1 more source