Results 131 to 140 of about 20,020 (230)

Efficacy and Safety of Adjunctive Perampanel in Young Children (7–46 Months) With Drug‐Resistant Epilepsy: A Real‐World Study

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
This real‐world study evaluates adjunctive perampanel (PER) in young children (7–46 months) with drug‐resistant epilepsy. Results show clinically meaningful efficacy, with responder rates of up to 50% in certain syndromes. PER demonstrates a favorable safety profile, supporting its role as an effective treatment option in this age group.
Qiao Zeng, Xueqian Xia, Hao Zheng, Lu Yang, Li Jiang, Yue Hu   +5 more
wiley   +1 more source

Hypoxic-Ischemic Encephalopathy in Newborns: Pathophysiology, Early Identification, and Management. [PDF]

Cureus
Alhosani MS, Sakvarelidze G.
europepmc   +1 more source

Pediatric Neuropalliative Medicine Clinic: Five‐Year Data Characterizing a Novel Model of Outpatient Care

Annals of the Child Neurology Society, Volume 4, Issue 2, Page 125-131, June 2026.
ABSTRACT Objective Pediatric neuropalliative medicine (PNPM) is a recently developed area of subspecialty neurology practice focused on supporting the complex emotional, psychological, and physical aspects of caring for a child with serious neurological disease.
Lauren Treat, Lori Silveira, Kevin C. Ess   +2 more
wiley   +1 more source

Time-dependent pattern of liver injury biomarkers in neonates with hypoxic-ischemic encephalopathy undergoing therapeutic hypothermia. [PDF]

Eur J Pediatr
Warlop J, Borloo N, Muniraman H, Michniewicz B, Kovacs K, Annaert P, Kayki G, Clarke P, Szpecht D, Szabo M, Fieuws S, Yalcin N, Smits A, Allegaert K.   +13 more
europepmc   +1 more source

Evolution of the European Medicines Agency clinical guidelines for epilepsy drug development between 2010 and 2025: A comparative analysis by the ILAE Task Force on Regulatory Affairs

Epilepsia, Volume 67, Issue 6, Page 2743-2754, June 2026.
Abstract Objective The latest European Medicines Agency (EMA) guideline on the clinical investigation of medicines to treat epileptic disorders was adopted by the EMA Committee for Medicinal Products for Human Use in 2025. We compared this guideline with the previous version (2010), highlighting areas where significant revisions were introduced ...
Stéphane Auvin, Alexis Arzimanoglou, Jacqueline French, Kelly G. Knupp, Lieven Lagae, Eugen Trinka, Dennis Dlugos, Emilio Perucca   +7 more
wiley   +1 more source

Data-driven wavelet coherence approach to assess neurovascular coupling in neonatal hypoxic-ischemic encephalopathy. [PDF]

Neurophotonics
Kota S, Norasteh S, Liu H, Bhandari EJ, Liu YL, Zhang R, Chalak LF.   +6 more
europepmc   +1 more source

Long‐term safety of early discontinuation of antiseizure medication after resolution of acute provoked neonatal seizures

Epilepsia, Volume 67, Issue 6, Page 2836-2844, June 2026.
Abstract Objective To assess long‐term safety of antiseizure medication (ASM) discontinuation after resolution of acute provoked neonatal seizures and prior to hospital discharge. Methods Prospective, observational, comparative effectiveness cohort study of neonates with acute provoked seizures born from July 2015 to March 2018, and followed until ...
Hannah C. Glass, Adam L. Numis, Janet S. Soul, Courtney J. Wusthoff, Monica E. Lemmon, Catherine J. Chu, Shavonne L. Massey, Cameron Thomas, Tayyba Anwar, Madison M. Berl, Jennifer G. Larson, Julie Sturza, Dana Annis, Elizabeth E. Rogers, Linda S. Franck, Charles E. McCulloch, Renée A. Shellhaas   +16 more
wiley   +1 more source

Comparison of Modified Sarnat Staging and Thompson Score in Neonatal Hypoxic-Ischemic Encephalopathy. [PDF]

Cureus
Gohatre H, Kulkarni RK, Ambike D, Haribhakta S, Mundlod S, Soni S, Patil V.   +6 more
europepmc   +1 more source

Diagnostic reassessment in patients previously diagnosed with childhood‐onset epilepsy during the transition to adult care: A retrospective cohort study in a tertiary epilepsy center

Epilepsia Open, Volume 11, Issue 3, Page 871-882, June 2026.
Abstract Objective To investigate the frequency, predictors, and clinical implications of diagnostic reassessment in patients previously diagnosed with childhood‐onset epilepsy during the transition period to adult care at a tertiary epilepsy center. Methods We conducted a retrospective cohort study of 317 patients previously diagnosed with childhood ...
Tetsuhiro Fukuyama, Masaru Nasuno, Manami Yabe, Makoto Nishioka, Yumi Hoshino, Takenori Natsume, Kohei Kanaya, Kyoko Takano, Tomoki Kaneko, Yushi Inoue   +9 more
wiley   +1 more source

A description of feeding and swallowing in neonates with hypoxic ischemic encephalopathy. [PDF]

S Afr J Commun Disord
Branfield S, Rhoda NR, Joemat J, Norman V.   +3 more
europepmc   +1 more source