Riociguat versus sildenafil on hypoxic pulmonary vasoconstriction and ventilation/perfusion matching. [PDF]
PLoS ONE, 2018 Current treatment with vasodilators for pulmonary hypertension associated with respiratory diseases is limited by their inhibitory effect on hypoxic pulmonary vasoconstriction (HPV) and uncoupling effects on ventilation-perfusion (V'/Q'). Hypoxia is also
Virginia Chamorro +11 more
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Hypoxic pulmonary vasoconstriction in humans. [PDF]
Biomed Res Int, 2013 Hypoxic pulmonary vasoconstriction is the elegant theory put forward more than six decades ago to explain regional variations in perfusion within the lung in certain animal species in response to localised restrictions in oxygenation. Although considerable progress has been made to describe the phenomenon at the macroscopic level and explain it at the ...
Ariyaratnam P, Loubani M, Morice AH.
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Hypoxic pulmonary vasoconstriction as a regulator of alveolar-capillary oxygen flux: A computational model of ventilation-perfusion matching. [PDF]
PLoS Computational Biology, 2021 The relationship between regional variabilities in airflow (ventilation) and blood flow (perfusion) is a critical determinant of gas exchange efficiency in the lungs.
Andrew D Marquis +3 more
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Dysregulation of the Nitric Oxide/Dimethylarginine Pathway in Hypoxic Pulmonary Vasoconstriction—Molecular Mechanisms and Clinical Significance [PDF]
Frontiers in Medicine, 2022 The pulmonary circulation responds to hypoxia with vasoconstriction, a mechanism that helps to adapt to short-lived hypoxic episodes. When sustained, hypoxic pulmonary vasoconstriction (HPV) may become deleterious, causing right ventricular hypertrophy ...
Juliane Hannemann +3 more
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Inhibition of ornithine decarboxylase restores hypoxic pulmonary vasoconstriction in endotoxemic mice [PDF]
Pulmonary Circulation, 2020 Endotoxemia impairs hypoxic pulmonary vasoconstriction which leads to systemic hypoxemia. This derogation is attributable to increased activity of nitric oxide synthase 2 and arginase metabolism. Gene expression analysis has shown increased expression of
P.H. Gebauer +4 more
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Revisiting the mechanism of hypoxic pulmonary vasoconstriction using isolated perfused/ventilated mouse lung [PDF]
Pulmonary Circulation, 2020 Hypoxic Pulmonary Vasoconstriction (HPV) is an important physiological mechanism of the lungs that matches perfusion to ventilation thus maximizing O 2 saturation of the venous blood within the lungs.
Pritesh P. Jain +15 more
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Impairment of hypoxic pulmonary vasoconstriction in acute respiratory distress syndrome [PDF]
European Respiratory Review, 2021 Acute respiratory distress syndrome (ARDS) is a serious complication of severe systemic or local pulmonary inflammation, such as caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
Mareike Gierhardt +8 more
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Arginase impairs hypoxic pulmonary vasoconstriction in murine endotoxemia [PDF]
Respiratory Research, 2019 Background Hypoxic pulmonary vasoconstriction (HPV) optimizes the match between ventilation and perfusion in the lung by reducing blood flow to poorly ventilated regions. Sepsis and endotoxemia impair HPV.
Bodil Petersen +7 more
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