Results 1 to 10 of about 41,058 (260)

The independent effects of hypovolemia and pulmonary vasoconstriction on ventricular function and exercise capacity during acclimatisation to 3800 m [PDF]

, 2018
We aimed to determine the isolated and combined contribution of hypovolemia and hypoxic pulmonary vasoconstriction in limiting left ventricular (LV) function and exercise capacity under chronic hypoxemia at high altitude.
Ainslie, Philip N., Anholm, James, Boulet, Lindsey M., Cooper, Stephen-Mark, Shave, Rob, Stembridge, Mike, Subedi, Prajan, Tymko, Michael M., Willie, Christopher K.   +8 more
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Pulmonary vascular reactivity to supplemental oxygen in Sherpa and lowlanders during gradual ascent to high altitude

Experimental Physiology, 2023
Prolonged alveolar hypoxia leads to pulmonary vascular remodelling. We examined the time course at altitude, over which hypoxic pulmonary vasoconstriction goes from being acutely reversible to potentially irreversible. Study subjects were lowlanders (n = 
Prajan Subedi, Christopher Gasho, Michael Stembridge, Alexandra M. Williams, Alexander Patrician, Philip N. Ainslie, James D. Anholm   +6 more
doaj   +1 more source

Review of hypoxaemia in the anaesthetized horse: predisposing factors, consequences and management [PDF]

, 2017
Objectives: To discuss how hypoxaemia might be harmful and why the horse is particularly predisposed to developing it. To review the strategies that are used to manage hypoxaemia in anaesthetised horses, to describe how successful these strategies are
Auckburally, Adam, Nyman, Görel
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Diacylglycerol regulates acute hypoxic pulmonary vasoconstriction via TRPC6

Respiratory Research, 2011
Background Hypoxic pulmonary vasoconstriction (HPV) is an essential mechanism of the lung that matches blood perfusion to alveolar ventilation to optimize gas exchange.
Grimminger Friedrich, Seeger Werner, Schermuly Ralph T, Ghofrani Hossein A, Rupp Markus, Fuchs Beate, Gudermann Thomas, Dietrich Alexander, Weissmann Norbert   +8 more
doaj   +1 more source

The α and Δ isoforms of CREB1 are required to maintain normal pulmonary vascular resistance.

PLoS ONE, 2013
Chronic hypoxia causes pulmonary hypertension associated with structural alterations in pulmonary vessels and sustained vasoconstriction. The transcriptional mechanisms responsible for these distinctive changes are unclear.
Lili Li, Katherine Howell, Michelle Sands, Mark Banahan, Stephen Frohlich, Simon C Rowan, Roisín Neary, Donal Ryan, Paul McLoughlin   +8 more
doaj   +1 more source

Micro-RNA-1 is decreased by hypoxia and contributes to the development of pulmonary vascular remodeling via regulation of sphingosine kinase 1 [PDF]

, 2018
Sphingosine kinase 1 (SphK1) upregulation is associated with pathologic pulmonary vascular remodeling in pulmonary arterial hypertension (PAH), but the mechanisms controlling its expression are undefined.
Chen, Jiwang, Comhair, Suzy, Machado, Roberto F., Natarajan, Viswanathan, Singla, Sunit, Sysol, Justin R., Zhao, Shuangping   +6 more
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Metabolism of asymmetric dimethylarginine in hypoxia: from bench to bedside

Pulmonary Circulation, 2020
Acute hypoxia and chronic hypoxia induce pulmonary vasoconstriction. While hypoxic pulmonary vasoconstriction is a physiological response if parts of the lung are affected, global exposure to hypoxic conditions may lead to clinical conditions like high ...
Juliane Hannemann, Julia Zummack, Jonas Hillig, Rainer Böger   +3 more
doaj   +1 more source

PKCα Deficiency in Mice Is Associated with Pulmonary Vascular Hyperresponsiveness to Thromboxane A2 and Increased Thromboxane Receptor Expression [PDF]

, 2015
Pulmonary vascular hyperresponsiveness is a main characteristic of pulmonary arterial hypertension (PAH). In PAH patients, elevated levels of the vasoconstrictors thromboxane A2 (TXA2), endothelin (ET)-1 and serotonin further contribute to pulmonary ...
Doehn, Jan-Moritz, Hippenstiel, Stefan, Klopfleisch, Robert, Naujoks, Jan, Noe, Elena, Opitz, Bastian, Suttorp, Norbert, Tabeling, Christoph, Witzenrath, Martin   +8 more
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Hypoxia, not pulmonary vascular pressure induces blood flow through intrapulmonary arteriovenous anastomoses [PDF]

, 2014
Blood flow through intrapulmonary arteriovenous anastomoses (IPAVA) is increased with exposure to acute hypoxia and has been associated with pulmonary artery systolic pressure (PASP).
A. William Sheel, Abbas, Akke Bakker, Albert, Andrew T. Lovering, Bain, Balanos, Bates, Benumof, Berk, Brimioulle, Bryan, Christie, Croft, Dorrington, Doyle, Eldridge, Elliott, Elliott, Elliott, Faoro, Foster, Fullerton, Giulio S. Dominelli, Glen E. Foster, Hohne, Hopkins, Imray, Joseph Donnelly, Joshua C. Tremblay, Kassamali, Keith R. Burgess, Kennedy, Ketabchi, Kollef, Laurie, Laurie, Levine, Lovering, Lovering, Lovering, Lovering, Lovering, Lovering, Lozo, Marriott, Mike Stembridge, Miller, Nia C.S. Lewis, Norris, Paolo B. Dominelli, Philip N. Ainslie, Querido, Roule, Rudski, Samuel J.E. Lucas, Stickland, Stickland, Stickland, Swenson, Swenson, Sylvester, Teppema, Tobin, Tobin, Tobin, Vazquez de Prada, Weil, William R. Henderson, Yildirimturk   +69 more
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AMPK and Pulmonary Hypertension: Crossroads Between Vasoconstriction and Vascular Remodeling

Frontiers in Cell and Developmental Biology, 2021
Pulmonary hypertension (PH) is a debilitating and life-threatening disease characterized by increased blood pressure within the pulmonary arteries. Adenosine monophosphate-activated protein kinase (AMPK) is a heterotrimeric serine-threonine kinase that ...
Qiang Zhao, Ping Song, Ming-Hui Zou
doaj   +1 more source