Results 91 to 100 of about 41,058 (260)

The serotonin transporter promotes a pathological estrogen metabolic pathway in pulmonary hypertension via cytochrome P450 1B1 pulmonary circulation [PDF]

, 2016
Pulmonary arterial hypertension (PAH) is a devastating vasculopathy that predominates in women and has been associated with dysregulated estrogen and serotonin signaling. Overexpression of the serotonin transporter (SERT+) in mice results in an estrogen-
Anagnostopoulou, Aikaterini, Dean, Afshan, Hood, Katie, Johansen, Anne Katrine Z., Loughlin, Lynn, MacLean, Margaret R., Morecroft, Ian, Nilsen, Margaret, Touyz, Rhian M., White, Kevin   +9 more
core   +1 more source

Dobutamine improves haemodynamics and oxygen delivery in standing and isoflurane‐anaesthetised horses

Equine Veterinary Journal, EarlyView.
Abstract Background Dobutamine is a first‐line therapy for hypotension in anaesthetised horses, but the effects on haemodynamic parameters in standing and anaesthetised horses are not well studied. Objectives To investigate the effects of dobutamine in escalating dosages on haemodynamic performance in awake and anaesthetised horses.
Emma B. Gorenberg, JoAnn Slack, Darko Stefanovski, DeAnna Theiss, Klaus Hopster   +4 more
wiley   +1 more source

Differences in Milk Production Efficiency and Physiology Between Lactating Holstein Cows and Yaks Born and Kept at About 4000 m of Altitude When Fed the Same Diet

Journal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT Yaks (Bos grunniens) have developed numerous mechanisms to cope with hypoxic environments. Still, as their milk yield is low, the use of production systems building on dairy breeds at high altitude might increase efficiency, but this has not yet been explored.
Xinyu Zhang, Michael Kreuzer, Mutian Niu, Shengli Li   +3 more
wiley   +1 more source

Severe asthma is associated with a remodeling of the pulmonary arteries in horses.

PLoS ONE, 2020
Pulmonary hypertension and cor pulmonale are complications of severe equine asthma, as a consequence of pulmonary hypoxic vasoconstriction. However, as pulmonary hypertension is only partially reversible by oxygen administration, other etiological ...
Serena Ceriotti, Michela Bullone, Mathilde Leclere, Francesco Ferrucci, Jean-Pierre Lavoie   +4 more
doaj   +1 more source

Regulation of oxygen sensing by ion channels [PDF]

, 2004
O2 sensing is of critical importance for cell survival and adaptation of living organisms to changing environments or physiological conditions. O2-sensitive ion channels are major effectors of the cellular responses to hypoxia.
Chiara, María D., Levitski, Konstantín, López Barneo, José, Ortega Sáenz, Patricia, Toro Estévez, Raquel del   +4 more
core   +1 more source

Effects of acute selective cyclooxygenase‐2 inhibition on skeletal muscle microvascular oxygenation and exercise tolerance

Experimental Physiology, EarlyView.
Abstract The cyclooxygenase (COX) pathway regulates vascular tone and, therefore, local O2 delivery‐utilization matching. The two main isoforms, COX‐1 and COX‐2, may promote opposing effects on contracting muscle O2 transport in health by inducing vasoconstriction and vasodilatation, respectively.
Michael D. Belbis, Michael J. Holmes, Joseph Yao, Christopher W. Kinnick, Christopher K. Kargl, Carly Day, Nicole L. Noel, Timothy P. Gavin, Bruno T. Roseguini, Daniel M. Hirai   +9 more
wiley   +1 more source

Clinical aspects of hypoxic pulmonary vasoconstriction [PDF]

Experimental Physiology, 1995
Although frequently unrecognized, hypoxic pulmonary vascular disease is an important cofactor in the morbidity and mortality of a wide spectrum of disease processes. The hypoxic response incorporates two distinct phases, the acute hypoxic vasoconstrictor response and vascular remodelling associated with prolonged alveolar hypoxia.
DF Treacher, R M Leach
openaire   +2 more sources

The Impact of Breathing Hypoxic Gas and Oxygen on Pulmonary Hemodynamics in Patients With Pulmonary Hypertension

Frontiers in Medicine, 2022
Background Pure oxygen breathing (hyperoxia) may improve hemodynamics in patients with pulmonary hypertension (PH) and allows to calculate right-to-left shunt fraction (Qs/Qt), whereas breathing normobaric hypoxia may accelerate hypoxic pulmonary ...
A. Carta, M. Lichtblau, C. Berlier, S. Saxer, S. Schneider, E. Schwarz, M. Furian, K. Bloch, S. Ulrich   +8 more
semanticscholar   +1 more source

Sustained Hypoxic Pulmonary Vasoconstriction in the Isolated Perfused Rat Lung: Effect of α1-adrenergic Receptor Agonist

Iranian Journal of Medical Sciences, 2014
Background: Alveolar hypoxia induces monophasic pulmonary vasoconstriction in vivo, biphasic vasoconstriction in the isolated pulmonary artery, and controversial responses in the isolated perfused lung.
Farzaneh Ketabchi, Zinab Karimi, Seyed Mostafa S. Moosavi   +2 more
doaj  

ESM‐1 and GBP‐1 are associated with endothelial dysfunction: emerging biomarkers or key players in the pathophysiology of preeclampsia?

The Journal of Physiology, EarlyView.
Abstract figure legend Endothelial specific molecule‐1 (ESM‐1) and guanylate binding protein‐1 (GBP‐1) are proteins that are produced by activated/dysfunctional endothelial cells and are increased and decreased, respectively, during preeclampsia. It remains to be established whether ESM‐1 and GBP‐1 could potentially be included as biomarkers for the ...
Ines Pronk, Joost H. N. Schuitemaker, Marijke M. Faas, Alexandra M. Smink   +3 more
wiley   +1 more source