Results 111 to 120 of about 41,058 (260)

Hypoxic pulmonary vasoconstriction: a multifactorial response? [PDF]

American Journal of Physiology-Lung Cellular and Molecular Physiology, 2001
hypoxic pulmonary vasoconstriction (HPV) is an essential mechanism that matches lung perfusion to ventilation to optimize pulmonary gas exchange (for reviews, see Refs. [9][1], [28][2], [31][3]).
Andrea Olschewski, Werner Seeger, Norbert Weissmann, Friedrich Grimminger   +3 more
openaire   +3 more sources

Breathing and balance: Clinical insights and management strategies of respiratory acid‐base disorders

Nutrition in Clinical Practice, Volume 40, Issue 4, Page 774-792, August 2025.
Abstract Respiratory acidosis and alkalosis are two of the four main acid‐base processes encountered in clinical practice. These two processes are tightly balanced by breathing. Identification and management of respiratory acid‐base disorders are important for clinicians, particularly when caring for patients with underlying pulmonary and neurological ...
Anne M. Tucker, Tami N. Johnson
wiley   +1 more source

Inhaled carbon monoxide protects time-dependently from loss of hypoxic pulmonary vasoconstriction in endotoxemic mice [PDF]

, 2015
Background: Inhaled carbon monoxide (CO) appears to have beneficial effects on endotoxemia-induced impairment of hypoxic pulmonary vasoconstriction (HPV).
Busch, Cornelius J., Busch, Thilo, Jahn, Nora, Kaisers, Udo X., Koel-Simmelink, Marleen J. A., Lamberts, Regis R., Loer, Stephan A., Oswald, Daniel D., Teunissen, Charlotte E, Voelker, Maria T., Weimann, Jörg   +10 more
core   +2 more sources

Effects of gestational intermittent hypoxia on the respiratory system: A tale of the placenta, fetus, and developing offspring

Journal of Sleep Research, Volume 34, Issue 4, August 2025.
Effects of gestational intermittent hypoxia on maternal, fetal and offspring respiratory system. In black, effects in humans; in red, in vitro effects; in blue, effects in animal models. Summary Obstructive sleep apnea (OSA) is a common sleep disorder that is associated with a wide variety of health conditions, including cardiovascular, cerebrovascular,
Esther Valverde‐Pérez, Elena Olea, Asunción Rocher, Philip I. Aaronson, Jesús Prieto‐Lloret   +4 more
wiley   +1 more source

Exaggerated hypoxic pulmonary vasoconstriction without susceptibility to high altitude pulmonary edema.

High Altitude Medicine & Biology, 2015
BACKGROUND Abnormally high pulmonary artery pressure (PAP) in hypoxia due to exaggerated hypoxic pulmonary vasoconstriction (HPV) is a key factor for development of high-altitude pulmonary edema (HAPE).
C. Dehnert, D. Mereles, S. Greiner, D. Albers, F. Scheurlen, S. Zügel, Thomas Böhm, P. Vock, M. Maggiorini, E. Grünig, P. Bärtsch   +10 more
semanticscholar   +1 more source

Hooray for Hypoxia? [PDF]

, 2005
The mortality of critically ill patients rises steadily as the partial pressure of arterial oxygen falls below about 11 kPa (80 mm Hg). A new animal study in the May 2005 issue of PLoS Biology showing a potential benefit for hypoxia is thus a challenge ...
Bellingan, G
core   +4 more sources

Glutamine Metabolism: Molecular Regulation, Biological Functions, and Diseases

MedComm, Volume 6, Issue 7, July 2025.
Tumor cells adapt to nutrient‐poor environments by altering metabolism to acquire essential nutrients. They convert glutamine into glutamate and α‐ketoglutarate, supporting mTOR activation and sugar biosynthesis. Disruption of mTORC1 signaling is linked to disease, while glutamine and leucine activation promotes cell growth and inhibits autophagy ...
Mudasir A. Kumar, Sana Khurshid Baba, Inamu Rashid Khan, Mohd Shahnawaz Khan, Fohad Mabood Husain, Saheem Ahmad, Mohammad Haris, Mayank Singh, Ammira S. Al‐Shabeeb Akil, Muzafar A. Macha, Ajaz A. Bhat   +10 more
wiley   +1 more source

Cytosolic phospholipase A2 in hypoxic pulmonary vasoconstriction [PDF]

Journal of Clinical Investigation, 2002
Cytosolic phospholipase A(2) (cPLA(2)) releases arachidonic acid (AA) from phospholipids in cell membranes. To assess the role of cPLA(2) in hypoxic pulmonary vasoconstriction (HPV), we measured the increase in left lung pulmonary vascular resistance (LPVR) before and during hypoxia produced by left main stem bronchus occlusion (LMBO) in mice with and ...
Fumito Ichinose, Warren M. Zapol, Joseph V. Bonventre, Adam Sapirstein, Kenneth D. Bloch, Rosemary Jones, Roman Ullrich, Charles N. Serhan   +7 more
openaire   +3 more sources

Hypoxic vasodilatory defect and pulmonary hypertension in mice lacking hemoglobin β-cysteine93 S-nitrosylation

JCI Insight, 2022
Systemic hypoxia is characterized by peripheral vasodilation and pulmonary vasoconstriction. However, the system-wide mechanism for signaling hypoxia remains unknown.
Rongli Zhang, Alfred Hausladen, Zhaoxia Qian, Xudong Liao, Richard T. Premont, Jonathan S. Stamler   +5 more
doaj   +1 more source

Dexfenfluramine and the oestrogen-metabolizing enzyme CYP1B1 in the development of pulmonary arterial hypertension [PDF]

, 2013
<p>Aims: Pulmonary arterial hypertension (PAH) occurs more frequently in women than men. Oestrogen and the oestrogen-metabolising enzyme cytochrome P450 1B1 (CYP1B1) play a role in the development of PAH.
Abenhaim, Archer, Audrey F. Wright, Austin, Badawi, Buters, Chin, Dempsie, Dempsie, Dempsie, Hanna, Hemnes, Higenbottam, Hironaka, Hong, Humbert, Humbert, Ian Morecroft, Jennings, Johnson, Kevin White, Kirsty M. Mair, Kramer, Lahm, Laroche-Clary, Launay, Lee, Lynn Loughlin, MacLean, MacLean, Margaret Nilsen, Margaret R. MacLean, Morecroft, Murray, Neil A. MacRitchie, Peacock, Reeve, Rosselli, Rothman, Rothman, Rothman, Savale, Simonneau, Stoilov, Tada, Thenappan, Tofovic, Tofovic, Weir, Weng, West, White, White, White, Yvonne Dempsie   +54 more
core   +1 more source