Results 121 to 130 of about 41,058 (260)
MedComm, Volume 6, Issue 7, July 2025.Lactate, beyond a metabolic byproduct, regulates immunity and inflammation, linked to cardiovascular diseases (CVD) via metabolic reprogramming. Lactylation, a lactate‐driven epigenetic mark, modulates gene expression in fibrosis, lipid disorders, and CVD progression.
Mengyang Song +3 more
wiley +1 more source
Pulmonary Circulation, Volume 15, Issue 3, July 2025.ABSTRACT Pulmonary arterial hypertension (PAH) is a progressive vascular disease characterized by small artery occlusion, increased pulmonary vascular resistance, and right heart failure. HSPH1, a member of the heat shock protein family, has been shown to inhibit protein aggregation but its role in PAH remains unclear.
Yuelong Ji +6 more
wiley +1 more source
Determinants of an elevated pulmonary arterial pressure in patients with pulmonary arterial hypertension [PDF]
, 2015 Given the difficulty of diagnosing early-stage pulmonary arterial hypertension (PAH) due to the lack of signs and symptoms, and the risk of an open lung biopsy, the precise pathological features of presymptomatic stage lung tissue remain unknown.
Sakao, Seiichiro +3 more
core +2 more sources
Journal of Anatomy, Volume 247, Issue 1, Page 134-143, July 2025.Obesity induced by a high fat diet caused hyperinnervation of the right ventricle, whereas chronic hypoxia alone did not significantly alter right ventricular innervation. Surprisingly, chronic hypoxia attenuated the obesity‐induced changes in right ventricular innervation.
Louisa‐Chiara Mierswa +2 more
wiley +1 more source
Journal of applied physiology, 2015 Hypoxic pulmonary vasoconstriction (HPV) is thought to actively regulate ventilation-perfusion (V̇a/Q̇) matching, reducing perfusion in regions of alveolar hypoxia.
Amran K. Asadi +13 more
semanticscholar +1 more source
Rotenone selectively occludes sensitivity to hypoxia in rat carotid body glomus cells [PDF]
, 2003 Carotid body glomus cells release transmitters in response to hypoxia due to the increase of excitability resulting from inhibition of O2 -regulated K+ channels. However, the mechanisms involved in the detection of changes of O2 tension are unknown.
García Fernández, María +3 more
core +2 more sources
Benzochalcogenodiazoles, Synthesis, and Applications in Medicinal Chemistry and Photomedicine
European Journal of Organic Chemistry, Volume 28, Issue 23, June 23, 2025.Benzochalcogenodiazoles (BXD) including benzoxadiazoles, benzothiadiazoles, and benzoselenadiazoles are initially mainly designed for optoelectronic materials as electron‐deficient cores. Nevertheless, they are now extending their application to biology.
Jean‐Elie Zheng +2 more
wiley +1 more source
Hypoxic Pulmonary Vasoconstriction Is Not Endothelium Dependent
Experimental Biology and Medicine, 1992 Feline intrapulmonary arteries (mean diameter, 0.9 mm) were equilibrated in Earle's solution at constant tension in a chamber bubbled with an hyperoxic gas mixture (30% oxygen, 5% carbon dioxide, balance nitrogen). The endothelium was removed from half the vessels by gentle rubbing.
B. E. Marshall, C. Marshall
openaire +3 more sources
Can sildenafil improve physical performance at altitude? Current scientific evidence [PDF]
, 2016 Sildenafil has proven to efficiently reduce the increase in pulmonary artery pressure provoked by hypoxic pulmonary vasoconstriction. However, its role as a possible factor in increasing exercise performance under hypoxic conditions remains to be ...
Javierre, Casimiro +4 more
core +1 more source
Inhaled nitric oxide for high-altitude pulmonary edema [PDF]
, 1996 BACKGROUND. Pulmonary hypertension is a hallmark of high-altitude pulmonary edema and may contribute to its pathogenesis. When administered by inhalation, nitric oxide, an endothelium-derived relaxing factor, attenuates the pulmonary vasoconstriction ...
Ballmer, P. E. +9 more
core +1 more source