Results 11 to 20 of about 12,758 (223)

Hypoxic pulmonary vasoconstriction does not limit maximal exercise capacity in healthy volunteers breathing 12% oxygen at sea level [PDF]

Physiological Reports
Maximal exercise capacity is reduced at altitude or during hypoxia at sea level. It has been suggested that this might reflect increased right ventricular afterload due to hypoxic pulmonary vasoconstriction.
Nick P. Talbot, Hung‐Yuan Cheng, Helen Hanstock, Thomas G. Smith, Keith L. Dorrington, Peter A. Robbins   +5 more
doaj   +2 more sources

Hypoxic pulmonary vasoconstriction. [PDF]

Physiol Rev, 2012
It has been known for more than 60 years, and suspected for over 100, that alveolar hypoxia causes pulmonary vasoconstriction by means of mechanisms local to the lung. For the last 20 years, it has been clear that the essential sensor, transduction, and effector mechanisms responsible for hypoxic pulmonary vasoconstriction (HPV) reside in the pulmonary
Sylvester JT, Shimoda LA, Aaronson PI, Ward JP.   +3 more
europepmc   +4 more sources

Hypoxic Pulmonary Vasoconstriction [PDF]

Chest, 1982
Hypoxic pulmonary vasoconstriction (HPV) is a homeostatic mechanism that, in the adult animal, diverts desaturated, mixed venous blood from poorly ventilated (hypoxic) areas of the lung to other, better ventilated (normoxic) areas of lung. Because of the relatively small amount of actively metabolizing tissue in the lungs, the proximity of the small ...
Ε. Kenneth Weir
openalex   +2 more sources

Cytochrome P450 Epoxygenase-Dependent Activation of TRPV4 Channel Participates in Enhanced Serotonin-Induced Pulmonary Vasoconstriction in Chronic Hypoxic Pulmonary Hypertension [PDF]

Analytical Cellular Pathology, 2020
Transient receptor potential vanilloid 4 (TRPV4) is a multi-functional non-selective channel expressed in pulmonary vasculatures. TRPV4 contributes to serotonin- (5-HT-) induced pulmonary vasoconstriction and is responsible in part for the enhanced 5-HT ...
Yang Xia, Lexin Xia, Zhou Jin, Rui Jin, Omkar Paudel, James S. K. Sham   +5 more
doaj   +2 more sources

Mitochondrial transplantation attenuates hypoxic pulmonary vasoconstriction. [PDF]

Oncotarget, 2016
Hypoxia triggers pulmonary vasoconstriction, however induces relaxation of systemic arteries such as femoral arteries. Mitochondria are functionally and structurally heterogeneous between different cell types. The aim of this study was to reveal whether mitochondrial heterogeneity controls the distinct responses of pulmonary versus systemic artery ...
Zhou J, Zhang J, Lu Y, Huang S, Xiao R, Zeng X, Zhang X, Li J, Wang T, Li T, Zhu L, Hu Q.   +11 more
europepmc   +4 more sources

Imaging Depiction of Hypoxic Pulmonary Vasoconstriction Using Dual-Energy CT. [PDF]

Cureus, 2023
Hunter JG, Prajapati P, Bera K, Gupta A, Gupta A.   +4 more
europepmc   +3 more sources

Ndufs2, a Core Subunit of Mitochondrial Complex I, Is Essential for Acute Oxygen-Sensing and Hypoxic Pulmonary Vasoconstriction. [PDF]

Circ Res, 2019
Dunham-Snary KJ, Wu D, Potus F, Sykes EA, Mewburn JD, Charles RL, Eaton P, Sultanian RA, Archer SL.   +8 more
europepmc   +3 more sources

Hypoxic Pulmonary Vasoconstriction [PDF]

Circulation Research, 2002
Reduction in alveolar oxygen tension causes reversible hypoxic pulmonary vasoconstriction (HPV), which is thought to serve as an adaptive mechanism for diverting blood flow from poorly ventilated to better-ventilated regions of the lung to improve ventilation-perfusion matching.
James S.K. Sham
openalex   +3 more sources

Analysis of flow resistance in the pulmonary arterial circulation: implications for hypoxic pulmonary vasoconstriction.

J Appl Physiol (1985), 2021
Johnson DW, Roy TK, Secomb TW.
europepmc   +3 more sources

Heterogeneous Perfusion in COVID-19 and High Altitude Pulmonary Edema: A Review of Two Cases Followed by Implications for Hypoxic Pulmonary Vasoconstriction, Thrombosis Development, Ventilation Perfusion Mismatch and Emergence of Treatment Approaches. [PDF]

Cureus, 2020
Solaimanzadeh I.
europepmc   +3 more sources