Hypoxic pulmonary vasoconstriction as a regulator of alveolar-capillary oxygen flux: A computational model of ventilation-perfusion matching. [PDF]
PLoS Computational Biology, 2021 The relationship between regional variabilities in airflow (ventilation) and blood flow (perfusion) is a critical determinant of gas exchange efficiency in the lungs.
Andrew D Marquis +3 more
doaj +3 more sources
Dysregulation of the Nitric Oxide/Dimethylarginine Pathway in Hypoxic Pulmonary Vasoconstriction—Molecular Mechanisms and Clinical Significance [PDF]
Frontiers in Medicine, 2022 The pulmonary circulation responds to hypoxia with vasoconstriction, a mechanism that helps to adapt to short-lived hypoxic episodes. When sustained, hypoxic pulmonary vasoconstriction (HPV) may become deleterious, causing right ventricular hypertrophy ...
Juliane Hannemann +3 more
doaj +3 more sources
Revisiting the mechanism of hypoxic pulmonary vasoconstriction using isolated perfused/ventilated mouse lung [PDF]
Pulmonary Circulation, 2020 Hypoxic Pulmonary Vasoconstriction (HPV) is an important physiological mechanism of the lungs that matches perfusion to ventilation thus maximizing O 2 saturation of the venous blood within the lungs.
Pritesh P. Jain +15 more
doaj +3 more sources
Impairment of hypoxic pulmonary vasoconstriction in acute respiratory distress syndrome [PDF]
European Respiratory Review, 2021 Acute respiratory distress syndrome (ARDS) is a serious complication of severe systemic or local pulmonary inflammation, such as caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
Mareike Gierhardt +8 more
doaj +3 more sources
Riociguat versus sildenafil on hypoxic pulmonary vasoconstriction and ventilation/perfusion matching. [PDF]
PLoS ONE, 2018 Current treatment with vasodilators for pulmonary hypertension associated with respiratory diseases is limited by their inhibitory effect on hypoxic pulmonary vasoconstriction (HPV) and uncoupling effects on ventilation-perfusion (V'/Q'). Hypoxia is also
Virginia Chamorro +11 more
doaj +3 more sources
Role of ATP-sensitive potassium channels on hypoxic pulmonary vasoconstriction in endotoxemia [PDF]
Respiratory Research, 2018 Background ATP-regulated potassium channels (KATP) regulate pulmonary vascular tone and are involved in hypoxic pulmonary vasoconstriction (HPV). In patients with inflammation like sepsis or ARDS, HPV is impaired, resulting in a ventilation-perfusion ...
Maurizio Turzo +4 more
doaj +6 more sources
Inhibition of ornithine decarboxylase restores hypoxic pulmonary vasoconstriction in endotoxemic mice [PDF]
Pulmonary Circulation, 2020 Endotoxemia impairs hypoxic pulmonary vasoconstriction which leads to systemic hypoxemia. This derogation is attributable to increased activity of nitric oxide synthase 2 and arginase metabolism. Gene expression analysis has shown increased expression of
P.H. Gebauer +4 more
doaj +2 more sources
The endothelium in hypoxic pulmonary vasoconstriction [PDF]
Journal of Applied Physiology, 2017 Hypoxic pulmonary vasoconstriction (HPV) in combination with hypercapnic pulmonary vasoconstriction redistributes pulmonary blood flow from poorly aerated to better ventilated lung regions by an active process of local vasoconstriction. Impairment of HPV results in ventilation-perfusion mismatch and is commonly associated with various lung diseases ...
Wolfgang M. Kuebler +3 more
openaire +4 more sources
Hypoxic Pulmonary Vasoconstriction in Humans: Tale or Myth. [PDF]
Open Cardiovasc Med J, 2017 Hypoxic Pulmonary vasoconstriction (HPV) describes the physiological adaptive process of lungs to preserves systemic oxygenation. It has clinical implications in the development of pulmonary hypertension which impacts on outcomes of patients undergoing cardiothoracic surgery. This review examines both acute and chronic hypoxic vasoconstriction focusing
Hussain A +4 more
europepmc +8 more sources
Arginase impairs hypoxic pulmonary vasoconstriction in murine endotoxemia [PDF]
Respiratory Research, 2019 Background Hypoxic pulmonary vasoconstriction (HPV) optimizes the match between ventilation and perfusion in the lung by reducing blood flow to poorly ventilated regions. Sepsis and endotoxemia impair HPV.
Bodil Petersen +7 more
doaj +2 more sources