Results 21 to 30 of about 41,058 (260)
Hypoxic Pulmonary Vasoconstriction: From Molecular Mechanisms to Medicine. [PDF]
Chest, 2017 Hypoxic pulmonary vasoconstriction (HPV) is a homeostatic mechanism that is intrinsic to the pulmonary vasculature. Intrapulmonary arteries constrict in response to alveolar hypoxia, diverting blood to better-oxygenated lung segments, thereby optimizing ventilation/perfusion matching and systemic oxygen delivery.
Dunham-Snary KJ +7 more
europepmc +5 more sources
Pulmonary Circulation, 2020 In healthy vascular endothelium, nitric oxide acts as a vasodilator paracrine mediator on adjacent smooth muscle cells. By activating soluble guanylyl cyclase, nitric oxide stimulates cyclic guanosine monophosphate (cGMP) which causes relaxation of ...
Rainer Böger, Juliane Hannemann
doaj +2 more sources
Hypoxic pulmonary vasoconstriction: role of voltage-gated potassium channels [PDF]
Respiratory Research, 2000 Activity of voltage-gated potassium (Kv) channels controls membrane potential, which subsequently regulates cytoplasmic free calcium concentration ([Ca2+]cyt) in pulmonary artery smooth muscle cells (PASMCs). Acute hypoxia inhibits Kv channel function in
Yuan Jason, Sweeney Michèle
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Hypoxic pulmonary vasoconstriction: clinical implications [PDF]
European Respiratory Journal, 2015 HPV is an adaptation for fetal development and affords some advantage in optimising gas exchange in adults http://ow.ly ...
J. Hughes
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Hypoxic pulmonary vasoconstriction does not limit maximal exercise capacity in healthy volunteers breathing 12% oxygen at sea level [PDF]
Physiological ReportsMaximal exercise capacity is reduced at altitude or during hypoxia at sea level. It has been suggested that this might reflect increased right ventricular afterload due to hypoxic pulmonary vasoconstriction.
Nick P. Talbot +5 more
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The LKB1-AMPK-α1 signaling pathway triggers hypoxic pulmonary vasoconstriction downstream of mitochondria [PDF]
Science Signaling, 2018 International audienceHypoxic pulmonary vasoconstriction (HPV), which aids ventilation-perfusion matching in the lungs, is triggered by mechanisms intrinsic to pulmonary arterial smooth muscles.
Evans, A Mark +11 more
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Hypoxic Pulmonary Vasoconstriction
Anesthesiology, 2015 AbstractAbstract Hypoxic pulmonary vasoconstriction (HPV) represents a fundamental difference between the pulmonary and systemic circulations. HPV is active in utero, reducing pulmonary blood flow, and in adults helps to match regional ventilation and perfusion although it has little effect in healthy lungs.
Peter Slinger, Andrew B Lumb
openaire +5 more sources
Pannexin 1: a novel regulator of acute hypoxic pulmonary vasoconstriction. [PDF]
Cardiovasc Res, 2022 AIMS Hypoxic pulmonary vasoconstriction (HPV) is a physiological response to alveolar hypoxia that diverts blood flow from poorly ventilated to better aerated lung areas to optimize ventilation-perfusion matching.
Grimmer B +9 more
europepmc +2 more sources
The hypoxic pulmonary vasoconstriction: From physiology to clinical application in thoracic surgery. [PDF]
Saudi J Anaesth, 2021 More than 70 years after its original report, the hypoxic pulmonary vasoconstriction (HPV) response continues to spark scientific interest on its mechanisms and clinical implications, particularly for anesthesiologists involved in thoracic surgery ...
Licker M +4 more
europepmc +2 more sources
Hypoxic pulmonary vasoconstriction [PDF]
BJA Education, 2017 M Powell, D Tarry
semanticscholar +5 more sources