Results 31 to 40 of about 12,758 (223)
Effect of High-Altitude Exposure on the Heart
Cardiology Discovery, 2023 High altitude brings a great physiological change in human beings, both during short-term exposure and in lifelong residents, especially in the cardiovascular system.
Lan Huang
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Kaohsiung Journal of Medical Sciences, 2011 There is now increasing evidence from the experimental and clinical setting that therapeutic hypercapnia from intentionally inspired carbon dioxide (CO2) or lower tidal volume might be a beneficial adjunct to the strategies of mechanical ventilation in ...
I-Chun Chuang +6 more
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Hypoxic Pulmonary Vasoconstriction [PDF]
Circulation Research, 2001 In 1894, when Bradford and Dean1 reported that asphyxia caused pulmonary hypertension, no one paid much attention. But ever since 1946, when von Euler and Liljestrand2 reported that acute hypoxia increased pulmonary arterial pressure attributable to pulmonary vasoconstriction, investigators have been hard at work to determine the underlying mechanisms.
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Pulmonary Circulation, 2020 Reabsorption of excess alveolar fluid is driven by vectorial Na + -transport across alveolar epithelium, which protects from alveolar flooding and facilitates gas exchange.
Emel Baloglu +6 more
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Hypoxic pulmonary vasoconstriction: role of voltage-gated potassium channels
Respiratory Research, 2000 Activity of voltage-gated potassium (Kv) channels controls membrane potential, which subsequently regulates cytoplasmic free calcium concentration ([Ca2+]cyt) in pulmonary artery smooth muscle cells (PASMCs). Acute hypoxia inhibits Kv channel function in
Yuan Jason, Sweeney Michèle
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The endothelium in hypoxic pulmonary vasoconstriction [PDF]
Journal of Applied Physiology, 2017 Hypoxic pulmonary vasoconstriction (HPV) in combination with hypercapnic pulmonary vasoconstriction redistributes pulmonary blood flow from poorly aerated to better ventilated lung regions by an active process of local vasoconstriction. Impairment of HPV results in ventilation-perfusion mismatch and is commonly associated with various lung diseases ...
Benjamin, Grimmer, Wolfgang M, Kuebler
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The α and Δ isoforms of CREB1 are required to maintain normal pulmonary vascular resistance.
PLoS ONE, 2013 Chronic hypoxia causes pulmonary hypertension associated with structural alterations in pulmonary vessels and sustained vasoconstriction. The transcriptional mechanisms responsible for these distinctive changes are unclear.
Lili Li +8 more
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Experimental Physiology, 2023 Prolonged alveolar hypoxia leads to pulmonary vascular remodelling. We examined the time course at altitude, over which hypoxic pulmonary vasoconstriction goes from being acutely reversible to potentially irreversible. Study subjects were lowlanders (n =
Prajan Subedi +6 more
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Metabolism of asymmetric dimethylarginine in hypoxia: from bench to bedside
Pulmonary Circulation, 2020 Acute hypoxia and chronic hypoxia induce pulmonary vasoconstriction. While hypoxic pulmonary vasoconstriction is a physiological response if parts of the lung are affected, global exposure to hypoxic conditions may lead to clinical conditions like high ...
Juliane Hannemann +3 more
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Endocannabinoid anandamide mediates hypoxic pulmonary vasoconstriction [PDF]
Proceedings of the National Academy of Sciences, 2013 SignificanceHypoxic pulmonary vasoconstriction (HPV) is an important physiological reflex, which is only found in the lung and adapts perfusion to ventilation. HPV is potentially involved in hypoxia-induced pulmonary hypertension (PH) occurring in respiratory disorders.
Daniela, Wenzel +6 more
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