Results 31 to 40 of about 41,058 (260)

β2-Adrenergic receptor-dependent attenuation of hypoxic pulmonary vasoconstriction prevents progression of pulmonary arterial hypertension in intermittent hypoxic rats. [PDF]

PLoS ONE, 2014
In sleep apnea syndrome (SAS), intermittent hypoxia (IH) induces repeated episodes of hypoxic pulmonary vasoconstriction (HPV) during sleep, which presumably contribute to pulmonary arterial hypertension (PAH).
Hisashi Nagai, Ichiro Kuwahira, Daryl O Schwenke, Hirotsugu Tsuchimochi, Akina Nara, Tadakatsu Inagaki, Sayoko Ogura, Yutaka Fujii, Keiji Umetani, Tatsuo Shimosawa, Ken-ichi Yoshida, James T Pearson, Koichi Uemura, Mikiyasu Shirai   +13 more
doaj   +2 more sources

Pathophysiology of Group 3 Pulmonary Hypertension Associated with Lung Diseases and/or Hypoxia. [PDF]

Int J Mol Sci
Pulmonary hypertension associated with lung diseases and/or hypoxia is classified as group 3 in the clinical classification of pulmonary hypertension. The efficacy of existing selective pulmonary vasodilators for group 3 pulmonary hypertension is still ...
Nakamura K, Akagi S, Ejiri K, Taya S, Saito Y, Kuroda K, Takaya Y, Toh N, Nakayama R, Katanosaka Y, Yuasa S.   +10 more
europepmc   +3 more sources

Ndufs2, a Core Subunit of Mitochondrial Complex I, Is Essential for Acute Oxygen-Sensing and Hypoxic Pulmonary Vasoconstriction. [PDF]

Circ Res, 2019
RATIONALE Hypoxic pulmonary vasoconstriction (HPV) optimizes systemic oxygen delivery by matching ventilation to perfusion. HPV is intrinsic to pulmonary artery smooth muscle cells (PASMCs).
Dunham-Snary KJ, Wu D, Potus F, Sykes EA, Mewburn JD, Charles RL, Eaton P, Sultanian RA, Archer SL.   +8 more
europepmc   +2 more sources

The effect of pco2 on hypoxic pulmonary vasoconstriction [PDF]

Canadian Anaesthetists’ Society Journal, 1981
Lung areas with a low V/Q ratio cause hypoxaemia. The low alveolar oxygen concentration may cause local hypoxic pulmonary vasoconstriction (HPV) which reduces perfusion, raises the V/Q ratio, and hence reduces the tendency to a low PaO2. By changing PCO2, the HPV response can be altered.
William H. Noble, J. Colin Kay, Joseph A. Fisher   +2 more
openalex   +4 more sources

Hypoxic Pulmonary Vasoconstriction and the Diffusing Capacity in Pulmonary Hypertension Secondary to Idiopathic Pulmonary Fibrosis [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Seiichiro Sakao, Nobuhiro Tanabe, Koichiro Tatsumi   +2 more
doaj   +2 more sources

Hypoxic pulmonary vasoconstriction in humans. [PDF]

Biomed Res Int, 2013
Hypoxic pulmonary vasoconstriction is the elegant theory put forward more than six decades ago to explain regional variations in perfusion within the lung in certain animal species in response to localised restrictions in oxygenation. Although considerable progress has been made to describe the phenomenon at the macroscopic level and explain it at the ...
Ariyaratnam P, Loubani M, Morice AH.
europepmc   +5 more sources

The Effects of Halothane in Hypoxic Pulmonary Vasoconstriction [PDF]

Anesthesiology, 1990
Human and animal experiments have not consistently shown halothane to inhibit hypoxic pulmonary vasoconstriction (HPV). The authors used a canine lung lobe perfused in situ to more precisely characterize the effects of halothane on HPV. The pulmonary vasculature can be divided into inflow, middle, and outflow segments by sequentially occluding the ...
David W. Johnson, Irvin Mayers, Teresa To   +2 more
openalex   +4 more sources

Hypoxic pulmonary vasoconstriction. [PDF]

Physiol Rev, 2012
It has been known for more than 60 years, and suspected for over 100, that alveolar hypoxia causes pulmonary vasoconstriction by means of mechanisms local to the lung. For the last 20 years, it has been clear that the essential sensor, transduction, and effector mechanisms responsible for hypoxic pulmonary vasoconstriction (HPV) reside in the pulmonary
Sylvester JT, Shimoda LA, Aaronson PI, Ward JP.   +3 more
europepmc   +5 more sources

Role of phosphatase and tensin homolog in hypoxic pulmonary vasoconstriction. [PDF]

Cardiovasc Res, 2017
Krauszman A, Mak TW, Szaszi K, Kuebler WM.   +3 more
europepmc   +2 more sources

Hypoxic Pulmonary Vasoconstriction Does Not Explain All Regional Perfusion Redistribution in Asthma. [PDF]

Am J Respir Crit Care Med, 2017
Kelly VJ, Hibbert KA, Kohli P, Kone M, Greenblatt EE, Venegas JG, Winkler T, Harris RS.   +7 more
europepmc   +2 more sources