Results 41 to 50 of about 41,058 (260)

The role of the endothelium in hypoxic pulmonary vasoconstriction [PDF]

Experimental Physiology, 1995
The precise mechanisms underlying hypoxic pulmonary vasoconstriction (HPV) are still elusive. The recent discovery of K+ channels that are depressed by hypoxia in pulmonary vascular smooth muscle has provided a potential signal transduction mechanism for linking a reduction in Po2 to Ca2+ entry, but there are many reports suggesting that sustained HPV ...
JP Ward, TP Robertson
openalex   +4 more sources

Research progress of endoplasmic reticulum stress of hypoxic pulmonary hypertension [PDF]

Jichu yixue yu linchuang, 2023
Hypoxic pulmonary hypertension (HPH) is a serious complication caused by long-term hypoxia,which is characterized by persistent vasoconstriction and irreversible vascular remodeling.
LIU Xingxing, WANG Weiwei, YUAN Haoxin
doaj   +1 more source

11,12-EET stimulates the association of BK channel α and β(1) subunits in mitochondria to induce pulmonary vasoconstriction [PDF]

, 2012
In the systemic circulation, 11,12-epoxyeicosatrienoic acid (11,12-EET) elicits nitric oxide (NO)- and prostacyclin-independent vascular relaxation, partially through the activation of large conductance Ca2+-activated potassium (BK) channels. However, in
Daiber, Andreas, Fleming, Ingrid, Keserü, Benjamin, Loot, Annemarieke E., Moneke, Isabelle, Oelze, Matthias, Syzonenko, Tetyana   +6 more
core   +4 more sources

A pig model of acute right ventricular afterload increase by hypoxic pulmonary vasoconstriction. [PDF]

BMC Res Notes, 2017
Knai K, Skjaervold NK.
europepmc   +2 more sources

Retracted: Chest digital dynamic radiography to detect changes in human pulmonary perfusion in response to alveolar hypoxia

Journal of Medical Radiation Sciences, 2023
Introduction Hypoxic pulmonary vasoconstriction optimises oxygenation in the lung by matching the local‐blood perfusion to local‐ventilation ratio upon exposure to alveolar hypoxia.
Shota Yamamoto, Fumio Sakamaki, Genki Takahashi, Yusuke Kondo, Naoya Taguchi, Shogo Esashi, Ryotaro Yuji, Katsuki Murakami, Kensuke Osaragi, Kosuke Tomita, Shunsuke Kamei, Tomohiro Matsumoto, Yutaka Imai, Terumitsu Hasebe   +13 more
doaj   +1 more source

Acetazolamide prevents hypoxia‐induced reactive oxygen species generation and calcium release in pulmonary arterial smooth muscle

Pulmonary Circulation, 2021
Upon sensing a reduction in local oxygen partial pressure, pulmonary vessels constrict, a phenomenon known as hypoxic pulmonary vasoconstriction. Excessive hypoxic pulmonary vasoconstriction can occur with ascent to high altitude and is a contributing ...
Larissa A. Shimoda, Karthik Suresh, Clark Undem, Haiyang Jiang, Xin Yun, J.T. Sylvester, Erik R. Swenson   +6 more
doaj   +1 more source

Influence of iron manipulation on hypoxic pulmonary vasoconstriction and pulmonary reactivity during ascent and acclimatization to 5050 m

Journal of Physiology, 2020
Iron acts as a cofactor in the stabilization of the hypoxic‐inducible factor family, and plays an influential role in the modulation of hypoxic pulmonary vasoconstriction. It is uncertain whether iron regulation is altered in lowlanders during either (1)
C. Willie, Alexander Patrician, R. Hoiland, A. Williams, Christopher Gasho, Prajan Subedi, J. Anholm, Aimee L Drane, M. Tymko, Daniela Nowak-Flück, S. Plato, Emily McBride, Giovanfrancesco Varoli, G. Binsted, Lindsay K. Eller, R. Reimer, D. Macleod, M. Stembridge, P. Ainslie   +18 more
semanticscholar   +1 more source

Repeated intermittent hypoxic stimuli to operative lung reduce hypoxemia during subsequent one-lung ventilation for thoracoscopic surgery: A randomized controlled trial.

PLoS ONE, 2021
BackgroundAn intervention to potentiate hypoxic pulmonary vasoconstriction may reduce intrapulmonary shunt and hypoxemia during one-lung ventilation.
Susie Yoon, Bo Rim Kim, Se-Hee Min, Jaehun Lee, Jae-Hyon Bahk, Jeong-Hwa Seo   +5 more
doaj   +1 more source

Correlation of Pulse Wave Transit Time with Pulmonary Artery Pressure in a Porcine Model of Pulmonary Hypertension

Biomedicines, 2021
For the non-invasive assessment of pulmonary artery pressure (PAP), surrogates like pulse wave transit time (PWTT) have been proposed. The aim of this study was to invasively validate for which kind of PAP (systolic, mean, or diastolic) PWTT is the best ...
Fabian Mueller-Graf, Jonas Merz, Tim Bandorf, Chiara Felicitas Albus, Maike Henkel, Lisa Krukewitt, Volker Kühn, Susanne Reuter, Brigitte Vollmar, Sven Pulletz, Stephan H. Böhm, Daniel A. Reuter, Amelie Zitzmann   +12 more
doaj   +1 more source

Mitochondrial transplantation attenuates hypoxic pulmonary vasoconstriction. [PDF]

Oncotarget, 2016
Hypoxia triggers pulmonary vasoconstriction, however induces relaxation of systemic arteries such as femoral arteries. Mitochondria are functionally and structurally heterogeneous between different cell types.
Zhou J, Zhang J, Lu Y, Huang S, Xiao R, Zeng X, Zhang X, Li J, Wang T, Li T, Zhu L, Hu Q.   +11 more
europepmc   +2 more sources