Results 41 to 50 of about 12,758 (223)

Diacylglycerol regulates acute hypoxic pulmonary vasoconstriction via TRPC6

Respiratory Research, 2011
Background Hypoxic pulmonary vasoconstriction (HPV) is an essential mechanism of the lung that matches blood perfusion to alveolar ventilation to optimize gas exchange.
Grimminger Friedrich, Seeger Werner, Schermuly Ralph T, Ghofrani Hossein A, Rupp Markus, Fuchs Beate, Gudermann Thomas, Dietrich Alexander, Weissmann Norbert   +8 more
doaj   +1 more source

AMPK and Pulmonary Hypertension: Crossroads Between Vasoconstriction and Vascular Remodeling

Frontiers in Cell and Developmental Biology, 2021
Pulmonary hypertension (PH) is a debilitating and life-threatening disease characterized by increased blood pressure within the pulmonary arteries. Adenosine monophosphate-activated protein kinase (AMPK) is a heterotrimeric serine-threonine kinase that ...
Qiang Zhao, Ping Song, Ming-Hui Zou
doaj   +1 more source

Genetic Diversity, Adaptation, Wild Introgression, and Coat Color Mutation of Golden Yak

Animal Research and One Health, EarlyView.
Genetic diversity, adaptation, wild introgression, and coat color mutation of golden yak from two populations on the Qinghai‐Xizang Plateau. ABSTRACT The golden yak lives on the Qinghai‐Xizang Plateau with a golden coat and adapts to high altitudes and strong ultraviolet environment. The golden coat is a prominent phenotype in many domesticated species,
Huixuan Yan, Jialei Chen, Chuzhao Lei, Fengwei Zhang, Shunzhong He, Weiru Song, Hongyan Ma, Shuling Li, Guomei Li, Laba Yongcuo, Jianlin Han, Johannes A. Lenstra, Qiang Zhang, Rende Song, Basang Wangdui, Ningbo Chen   +15 more
wiley   +1 more source

Oxygen sensors in hypoxic pulmonary vasoconstriction [PDF]

Cardiovascular Research, 2006
Hypoxic pulmonary vasoconstriction (HPV) is an essential mechanism adapting lung perfusion to regional ventilation. Perturbations to HPV, such as those occurring in pneumonia, acute respiratory distress syndrome and liver failure, can result in arterial hypoxemia. Under conditions of general hypoxia, HPV increases pulmonary vascular resistance and thus
Norbert, Weissmann, Natascha, Sommer, Ralph Theo, Schermuly, Hossein Ardeschir, Ghofrani, Werner, Seeger, Friedrich, Grimminger   +5 more
openaire   +2 more sources

Quantitative MRI Values for Atrial and Ventricular Parameters in Altitude‐Dwelling Youth

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background The hypoxic environment on the Qinghai Plateau significantly exacerbates myocardial remodeling, with sex/ethnicity‐specific variations in cardiac parameters among local youth. Current cardiac MRI reference values lack data from physiologically adapted populations on this plateau.
Xiumei Xiao, Hui Xu
wiley   +1 more source

β2-Adrenergic receptor-dependent attenuation of hypoxic pulmonary vasoconstriction prevents progression of pulmonary arterial hypertension in intermittent hypoxic rats. [PDF]

PLoS ONE, 2014
In sleep apnea syndrome (SAS), intermittent hypoxia (IH) induces repeated episodes of hypoxic pulmonary vasoconstriction (HPV) during sleep, which presumably contribute to pulmonary arterial hypertension (PAH).
Hisashi Nagai, Ichiro Kuwahira, Daryl O Schwenke, Hirotsugu Tsuchimochi, Akina Nara, Tadakatsu Inagaki, Sayoko Ogura, Yutaka Fujii, Keiji Umetani, Tatsuo Shimosawa, Ken-ichi Yoshida, James T Pearson, Koichi Uemura, Mikiyasu Shirai   +13 more
doaj   +1 more source

Hypoxic pulmonary vasoconstriction: clinical implications [PDF]

European Respiratory Journal, 2015
HPV is an adaptation for fetal development and affords some advantage in optimising gas exchange in adults http://ow.ly ...
openaire   +2 more sources

Analysis of Pulsatile Vessel Expansion in Healthy, COPD‐and PH‐Patients Using Dynamic Vessel Segmentation in Free‐Breathing Lung MRI

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background The pulsatile expansion of pulmonary vessels carries dynamic cardiopulmonary information that may reveal disease earlier than structural changes alone. Purpose To test (i) intra‐ and inter‐scan repeatability of dynamic vessel metrics in healthy subjects, and (ii) whether chronic obstructive pulmonary disease (COPD) and postcapillary
Julian Glandorf, Marius M. Klein, Filip Klimeš, Agilo Luitger Kern, Marcel Gutberlet, Jens M. Hohlfeld, Marius M. Hoeper, Karen M. Olsson, Frank Wacker, Jens Vogel‐Claussen, Andreas Voskrebenzev   +10 more
wiley   +1 more source

Comparison of the effect of sevoflurane and propofol on oxygenation during gradual transition to one-lung ventilation

Brazilian Journal of Anesthesiology, 2014
Background: It is known that hypoxic pulmonary vasoconstriction increases as a result of intermittent regional hypoxic challenges. The aim of this study was to compare the effects of sevoflurane and propofol on oxygenation and shunt fraction during one ...
Ayşe Karci, Seden Duru, Hasan Hepağuşlar, Lügen Çiftçi, Osman Yilmaz   +4 more
doaj   +1 more source

Nicardipine‐induced acute respiratory failure: Case report and literature review

Clinical Case Reports, 2023
Hypoxic pulmonary vasoconstriction (HPV) is a major physiological mechanism that prevents the development of hypoxemia secondary to a regional decrease in the ventilation–perfusion ratio (the intrapulmonary shunt effect). Calcium plays a critical role in
Gizzatullin Timour, Vallot Fréderic, Simonet Olivier, Didier Ndjekembo Shango   +3 more
doaj   +1 more source