Results 51 to 60 of about 12,758 (223)

Mechanisms and clinical translation of high altitudepulmonary edema: current status and future prospects

生物医学转化, 2021
High altitude pulmonary edema (HAPE) is a form of life-threatening high altitude idiopathy.This non-cardiogenic pulmonary edema is a serious illness with high risk of morbidity.
Gao Wenxiang, Wu Gang, Xu Licong, Gao Yuqi   +3 more
doaj   +1 more source

Hypoxic pulmonary vasoconstriction: mechanisms and controversies [PDF]

The Journal of Physiology, 2005
The pulmonary circulation differs from the systemic in several important aspects, the most important being that pulmonary arteries constrict to moderate physiological (∼20–60 mmHg PO2) hypoxia, whereas systemic arteries vasodilate. This phenomenon is called hypoxic pulmonary vasoconstriction (HPV), and is responsible for maintaining the ventilation ...
Philip I, Aaronson, Tom P, Robertson, Gregory A, Knock, Silke, Becker, Tristan H, Lewis, Vladimir, Snetkov, Jeremy P T, Ward   +6 more
openaire   +3 more sources

Circadian Immunity and Vascular Inflammation in Cardiovascular Disease Chronotherapy Windows: Time for a Re‐Assessment

Med Research, EarlyView.
ABSTRACT Circadian rhythms orchestrate cardiovascular physiology by regulating immune and inflammatory pathways. Disruption of these rhythms profoundly alters vascular homeostasis, thereby promoting the onset and progression of cardiovascular diseases (CVD).
Tian Zhang, Ge Zhang, Tian‐Ding Liu, Tianshu Gu, Fengyi Yu, Pengyuan Xu, Wunan Mi, Xuanjiang Zhao, Qian Guo, Honglin Zheng, Taiqi Zhao, Qiang Li, Di Lu, Mingxuan Duan, Chaoyang Yu, Ruhao Wu, Shiqian Zhang, Haonan Zhang, Zeyu Wang, Youyang Zheng, Yan Xiao, Zenglei Zhang, Ge Zhang   +22 more
wiley   +1 more source

Revisiting the Role of TRP, Orai, and ASIC Channels in the Pulmonary Arterial Response to Hypoxia

Frontiers in Physiology, 2018
The pulmonary arteries are exquisitely responsive to oxygen changes. They rapidly and proportionally contract as arterial PO2 decrease, and they relax as arterial PO2 is re-established.
Roberto V. Reyes, Roberto V. Reyes, Sebastián Castillo-Galán, Ismael Hernandez, Emilio A. Herrera, Emilio A. Herrera, Germán Ebensperger, Germán Ebensperger, Aníbal J. Llanos, Aníbal J. Llanos   +9 more
doaj   +1 more source

Connexin 43 plays a role in proliferation and migration of pulmonary arterial fibroblasts in response to hypoxia

Pulmonary Circulation, 2020
Pulmonary hypertension (PH) is a disease associated with vasoconstriction and remodelling of the pulmonary vasculature. Pulmonary artery fibroblasts (PAFs) play an important role in hypoxic-induced remodelling.
Andrew J. McNair, Kathryn S. Wilson, Patricia E. Martin, David J. Welsh, Yvonne Dempsie   +4 more
doaj   +1 more source

Pulmonary Hypertension in COVID-19 Pneumoniae: It Is Not Always as It Seems

European Journal of Case Reports in Internal Medicine, 2020
A patient affected by COVID-19 pneumonia may develop pulmonary hypertension (PH) and secondary right ventricular (RV) involvement, due to lung parenchymal and interstitial damage and altered pulmonary haemodynamics, even in non-advanced phases of the ...
Maria Cristina Pasqualetto, Maria Domenica Sorbo, Maria Vitiello, Chiara Ferrara, Moreno Scevola, Fabio Pantalone, Fabio Gelain, Claudio Aloi, Manuele Nizzetto, Fausto Rigo   +9 more
doaj   +1 more source

Clinical aspects of hypoxic pulmonary vasoconstriction [PDF]

Experimental Physiology, 1995
Although frequently unrecognized, hypoxic pulmonary vascular disease is an important cofactor in the morbidity and mortality of a wide spectrum of disease processes. The hypoxic response incorporates two distinct phases, the acute hypoxic vasoconstrictor response and vascular remodelling associated with prolonged alveolar hypoxia.
R M, Leach, D F, Treacher
openaire   +2 more sources

Sympatho‐Excitation in Pulmonary Hypertension: The Potential Role of Pulmonary Arterial Baroreceptors: An Acute Physiologic Intervention Study

Respirology, EarlyView.
Pulmonary arterial baroreceptors reflexively stimulate sympathetic nerve activity (SNA) in response to elevated pulmonary artery pressure and distension. In pulmonary hypertension patients, changes in muscle SNA were proportional to changes in pulmonary haemodynamics following nebulised iloprost.
Michael J. Plunkett, Ana L. C. Sayegh, Robert A. Lewis, Tanya J. McWilliams, Sasiharan Sithamparanathan, Julian F. R. Paton, James P. Fisher   +6 more
wiley   +1 more source

The effects of genetic deletion of Macrophage migration inhibitory factor on the chronically hypoxic pulmonary circulation

Pulmonary Circulation, 2020
While it is well established that the haemodynamic cause of hypoxic pulmonary hypertension is increased pulmonary vascular resistance, the molecular pathogenesis of the increased resistance remains incompletely understood. Macrophage migration inhibitory
Lili Li, Maojia Xu, Simon C. Rowan, Katherine Howell, Adam Russell-Hallinan, Seamas C. Donnelly, Paul McLoughlin, John A. Baugh   +7 more
doaj   +1 more source

Cardiovascular Plasticity and Adaptation of High‐Altitude Birds and Mammals

Integrative Zoology, EarlyView.
This schematic depicts the cardiovascular adaptations of mammals and birds to high‐altitude hypoxia. It highlights key phenotypic changes in oxygen transport and cardiac responses, driven by molecular mechanisms including transcriptional regulation and genetic modifications.
Huishang She, Yanhua Qu
wiley   +1 more source