Results 61 to 70 of about 41,058 (260)
Kaohsiung Journal of Medical Sciences, 2011 There is now increasing evidence from the experimental and clinical setting that therapeutic hypercapnia from intentionally inspired carbon dioxide (CO2) or lower tidal volume might be a beneficial adjunct to the strategies of mechanical ventilation in ...
I-Chun Chuang +6 more
doaj +1 more source
The effects on arterial haemoglobin oxygen saturation and on shunt of increasing cardiac output with dopamine or dobutamine during one-lung ventilation [PDF]
, 2004 Publisher's copy made available with the permission of the publisher © Australian Society of AnaesthetistsTheoretically, if the cardiac output were increased in the presence of a given intrapulmonary shunt, the arterial saturation should improve as the ...
Furman W.R. +4 more
core +2 more sources
Hypoxic regulation of ion channel function and expression [PDF]
, 2002 Acute hypoxia regulates the activity of specific ion channels in a rapid and reversible manner. Such effects underlie appropriate cellular responses to hypoxia which are designed to initiate cardiorespiratory reflexes and contribute importantly to other ...
Peers, C.
core +1 more source
American Journal of Physiology - Cell Physiology, 2013 Transient receptor potential vanilloid 4 (TRPV4) is a mechanosensitive channel in pulmonary arterial smooth muscle cells (PASMCs). Its upregulation by chronic hypoxia is associated with enhanced myogenic tone, and genetic deletion of trpv4 suppresses the
Yang Xia +7 more
semanticscholar +1 more source
Sensors and signals: the role of reactive oxygen species in hypoxic pulmonary vasoconstriction
Journal of Physiology, 2018 When lung cells experience hypoxia, the functional response, termed hypoxic pulmonary vasoconstriction, activates a multitude of pathways with the goal of optimizing gas exchange.
Kimberly A. Smith, P. Schumacker
semanticscholar +1 more source
Notch Activation of Ca(2+) Signaling in the Development of Hypoxic Pulmonary Vasoconstriction and Pulmonary Hypertension. [PDF]
Am J Respir Cell Mol Biol, 2015 Hypoxic pulmonary vasoconstriction (HPV) is an important physiological response that optimizes the ventilation/perfusion ratio. Chronic hypoxia causes vascular remodeling, which is central to the pathogenesis of hypoxia-induced pulmonary hypertension ...
Smith KA +18 more
europepmc +2 more sources
Attenuation of human hypoxic pulmonary vasoconstriction by acetazolamide and methazolamide.
Journal of applied physiology, 2018 RATIONALE Acetazolamide, a carbonic anhydrase inhibitor used for preventing altitude illness attenuates hypoxic pulmonary vasoconstriction (HPV) while improving oxygenation. Methazolamide, an analog of acetazolamide, is more lipophilic, has a longer half-
Lindsey M. Boulet +10 more
semanticscholar +1 more source
Hypoxic pulmonary vasoconstriction: mechanisms and controversies [PDF]
The Journal of Physiology, 2005 The pulmonary circulation differs from the systemic in several important aspects, the most important being that pulmonary arteries constrict to moderate physiological (∼20–60 mmHg PO2) hypoxia, whereas systemic arteries vasodilate. This phenomenon is called hypoxic pulmonary vasoconstriction (HPV), and is responsible for maintaining the ventilation ...
Philip I. Aaronson +6 more
openalex +6 more sources
Pulmonary Circulation, 2020 Reabsorption of excess alveolar fluid is driven by vectorial Na + -transport across alveolar epithelium, which protects from alveolar flooding and facilitates gas exchange.
Emel Baloglu +6 more
doaj +1 more source
Hypoxic pulmonary vasoconstriction in isolated mouse pulmonary arterial vessels
Experimental Physiology, 2018 What is the central question of this study? Hypoxic pulmonary vasoconstriction has never been characterized in isolated mouse pulmonary arteries of different generations in detail. What is the main finding and its importance?
I. Strielkov +8 more
semanticscholar +1 more source