Results 71 to 80 of about 41,058 (260)
Hypoxic Pulmonary Vasoconstriction [PDF]
Circulation Research, 2001 In 1894, when Bradford and Dean1 reported that asphyxia caused pulmonary hypertension, no one paid much attention. But ever since 1946, when von Euler and Liljestrand2 reported that acute hypoxia increased pulmonary arterial pressure attributable to pulmonary vasoconstriction, investigators have been hard at work to determine the underlying mechanisms.
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Oxygen sensors in hypoxic pulmonary vasoconstriction [PDF]
Cardiovascular Research, 2006 Hypoxic pulmonary vasoconstriction (HPV) is an essential mechanism adapting lung perfusion to regional ventilation. Perturbations to HPV, such as those occurring in pneumonia, acute respiratory distress syndrome and liver failure, can result in arterial hypoxemia. Under conditions of general hypoxia, HPV increases pulmonary vascular resistance and thus
Natascha Sommer +5 more
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Connexin 43 plays a role in pulmonary vascular reactivity in mice [PDF]
, 2018 Pulmonary arterial hypertension (PAH) is a chronic condition characterized by vascular remodeling and increased vaso-reactivity. PAH is more common in females than in males (~3:1).
Andrew Shaw +11 more
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Tetrahydrobiopterin and the regulation of hypoxic pulmonary vasoconstriction [PDF]
European Respiratory Journal, 2010 Tetrahydrobiopterin (BH4) is an essential cofactor for nitric oxide synthases (NOS). This study investigated the effect of increasing BH4levels on hypoxia-induced pulmonary vasoconstriction (HPV).Sprague Dawley rats and hph-1 (BH4deficient) mice were given BH4before and during HPV in an isolated perfused lung preparation.
Lan Zhao +2 more
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Nicardipine‐induced acute respiratory failure: Case report and literature review
Clinical Case Reports, 2023 Hypoxic pulmonary vasoconstriction (HPV) is a major physiological mechanism that prevents the development of hypoxemia secondary to a regional decrease in the ventilation–perfusion ratio (the intrapulmonary shunt effect). Calcium plays a critical role in
Gizzatullin Timour +3 more
doaj +1 more source
MECHANISMS OF DISEASE Acute Oxygen-Sensing Mechanisms [PDF]
, 2005 JOSEPH PRIESTLEY, ONE OF THE THREE SCIENTISTS CREDITED WITH THE discovery of oxygen, described the death of mice that were deprived of oxygen. However, he was also well aware of the toxicity of too much oxygen, stating, “For as a candle burns much faster
Buckler, Keith J. +3 more
core
Iatrogenic pulsus alternans in a dog undergoing median sternotomy
Veterinary Record Case Reports, EarlyView.Abstract A 6‐year‐old, 21.8 kg, female, spayed Siberian husky was referred for management of a spontaneous bilateral pneumothorax, due to a ruptured pulmonary bleb. During surgery, sterile saline was instilled on three occasions in order to locate the damaged lung tissue and ensure complete ligation.
Marie‐Line Doï +2 more
wiley +1 more source
A narrative review of research advances in hypoxic pulmonary hypertension
Annals of Translational Medicine, 2022 Background and Objective Hypoxic pulmonary hypertension (HPH) is a pathological syndrome characterized by pulmonary vasoconstriction and pulmonary vascular remodeling caused by hypoxia, which eventually leads to right heart failure or death.
Tianci Chai +5 more
semanticscholar +1 more source
AMPK and the Challenge of Treating Hypoxic Pulmonary Hypertension
International Journal of Molecular Sciences, 2022 Hypoxic pulmonary hypertension (HPH) is characterized by sustained elevation of pulmonary artery pressure produced by vasoconstriction and hyperproliferative remodeling of the pulmonary artery and subsequent right ventricular hypertrophy (RVH).
Karen Flores +3 more
semanticscholar +1 more source
Cardiovascular Plasticity and Adaptation of High‐Altitude Birds and Mammals
Integrative Zoology, EarlyView.This schematic depicts the cardiovascular adaptations of mammals and birds to high‐altitude hypoxia. It highlights key phenotypic changes in oxygen transport and cardiac responses, driven by molecular mechanisms including transcriptional regulation and genetic modifications.
Huishang She, Yanhua Qu
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