Results 71 to 80 of about 12,758 (223)

Thin Air, Thick Vessels: Historical and Current Perspectives on Hypoxic Pulmonary Hypertension

Frontiers in Medicine, 2019
The association between pulmonary hypertension (PH) and hypoxia is well-established, with two key mechanistic processes, hypoxic pulmonary vasoconstriction and hypoxia-induced vascular remodeling, driving changes in pulmonary arterial pressure.
Jason M. Young, Jason M. Young, David R. Williams, A. A. Roger Thompson, A. A. Roger Thompson   +4 more
doaj   +1 more source

A comparison of normobaric and hypobaric hypoxia effects on cerebrovascular response pre and post maximal exercise

Experimental Physiology, EarlyView.
Abstract A lack of consensus remains on whether normobaric hypoxia (NH) and hypobaric hypoxia (HH) may differentially impact physiological factors affecting cerebrovascular regulation, particularly with an additional strenuous exercise component. We sought to compare the acute effects of NH and HH on global cerebral blood flow (gCBF) at an altitude ...
Rachel Turner, Giovanni Vinetti, Giacomo Strapazzon, Hannes Gatterer   +3 more
wiley   +1 more source

Hypoxia-induced pulmonary vasoconstriction of intra-acinar arteries is impaired in NADPH oxidase 4 gene-deficient mice

Pulmonary Circulation, 2018
We show that genetic deficiency of the reactive oxygen species generating enzyme NADPH oxidase 4 (NOX4) impairs hypoxic pulmonary vasoconstriction in small (25–40 µm) intra-acinar, but not pre-acinar, arteries in murine precision cut lung slices.
Ghulam Murtaza, Renate Paddenberg, Uwe Pfeil, Anna Goldenberg, Petra Mermer, Wolfgang Kummer   +5 more
doaj   +1 more source

Cardiovascular, respiratory and splenic responses to rebreathing and apnoea during exercise

Experimental Physiology, EarlyView.
Abstract We investigated integrative physiological responses to eupnoeic exercise (EX), rebreathing exercise (RB), dynamic apnoea (DA) and dynamic apnoea with cold‐water face immersion (DAFI) in 20 healthy participants. Trials involved non‐steady‐state cycle exercise at 60 W for an average duration of 66 s.
Theodore Dotevall, Maja Persson, Bodil Sjögreen, Mats H. Linér, Angelica Lodin‐Sundström, Johan P. A. Andersson   +5 more
wiley   +1 more source

ESM‐1 and GBP‐1 are associated with endothelial dysfunction: emerging biomarkers or key players in the pathophysiology of preeclampsia?

The Journal of Physiology, EarlyView.
Abstract figure legend Endothelial specific molecule‐1 (ESM‐1) and guanylate binding protein‐1 (GBP‐1) are proteins that are produced by activated/dysfunctional endothelial cells and are increased and decreased, respectively, during preeclampsia. It remains to be established whether ESM‐1 and GBP‐1 could potentially be included as biomarkers for the ...
Ines Pronk, Joost H. N. Schuitemaker, Marijke M. Faas, Alexandra M. Smink   +3 more
wiley   +1 more source

Hypoxic vasodilatory defect and pulmonary hypertension in mice lacking hemoglobin β-cysteine93 S-nitrosylation

JCI Insight, 2022
Systemic hypoxia is characterized by peripheral vasodilation and pulmonary vasoconstriction. However, the system-wide mechanism for signaling hypoxia remains unknown.
Rongli Zhang, Alfred Hausladen, Zhaoxia Qian, Xudong Liao, Richard T. Premont, Jonathan S. Stamler   +5 more
doaj   +1 more source

Acute intermittent hypercapnic hypoxia augments left ventricular contractility

The Journal of Physiology, EarlyView.
Abstract figure legend Twenty‐four healthy adults were studied to determine the effects of an acute session of 40 min of intermittent hypercapnic hypoxia on cardiac performance. Cardiac function was assessed via echocardiography at rest and during graded stages of lower‐body negative pressure before and after the intervention to quantify load ...
Scott F. Thrall, Alex M. Williams, Philip J. Millar, Megan L. Lance, Brooke M. Shafer, Conan L. H. Shing, Jordan D. Bird, Christopher R. West, Glen E. Foster   +8 more
wiley   +1 more source

Pulmonary arterial mechanoreceptors modulate exercise‐induced sympathetic activation in healthy humans during moderate‐intensity hypoxic exercise

The Journal of Physiology, EarlyView.
Abstract figure legend This randomized cross‐over trial (N = 12) addressed the hypothesis that selective reduction of pulmonary arterial pressure (i.e. manipulation of pulmonary arterial mechanoreceptor activation) during hypoxic exercise would reduce sympathetic outflow (muscle sympathetic nerve activity (MSNA)) in healthy humans.
Michiel T. Ewalts, Thomas D. Griffiths, Andrew J. M. Douglas, Elliott J. Jenkins, Guto Wyn Hughes, Craig D. Steinback, Lydia L. Simpson, Samuel J. Oliver, Mike Stembridge, Jonathan P. Moore   +9 more
wiley   +1 more source

The role of acid‐base balance in cerebrovascular and ventilatory responses to CO2 during 10 h normobaric hypoxia

The Journal of Physiology, EarlyView.
Abstract figure legend During 10 h exposures to normobaric hypoxia exposure there was a selective leftward shift in ventilatory response to hyperoxic hypercapnic rebreathing, but not the cerebrovascular response. The key findings are that the resetting of the central chemoreflex to lower PCO2${P_{{\mathrm{C}}{{\mathrm{O}}_2}}}$ during early hypoxic ...
Holly Barclay, Saptarshi Mukerji, Bengt Kayser, Jui‐Lin Fan   +3 more
wiley   +1 more source

Ventilatory and cerebrovascular responses to exercise in lowlander children acclimatizing to high‐altitude

The Journal of Physiology, EarlyView.
Abstract figure legend To investigate age‐related differences in ventilatory and cerebrovascular responses to exercise at high‐altitude, adults (n = 10, 23–44 years) and children (n = 8, 7–14 years) completed progressive cycling exercise tests at sea‐level and following 6 days of acclimatization at 3800 m.
J. L. Koep, M. G. Rieger, K. J. Smith, G. R. DuManoir, C. M. Tallon, D. R. Perkins, S. Piombo, M. Stembridge, D. M. Cooper, S. Radom‐Aizik, P. N. Ainslie, A. M. McManus   +11 more
wiley   +1 more source