Results 81 to 90 of about 41,058 (260)

Cytochrome P450 Epoxygenase-Dependent Activation of TRPV4 Channel Participates in Enhanced Serotonin-Induced Pulmonary Vasoconstriction in Chronic Hypoxic Pulmonary Hypertension

open access: yesAnalytical Cellular Pathology, 2020
Transient receptor potential vanilloid 4 (TRPV4) is a multi-functional non-selective channel expressed in pulmonary vasculatures. TRPV4 contributes to serotonin- (5-HT-) induced pulmonary vasoconstriction and is responsible in part for the enhanced 5-HT ...
Yang Xia   +5 more
doaj   +1 more source

Investigating M101's Effect in Improving Cardiac and Diaphragmatic Mechanical and Functional Properties on Wistar Rat

open access: yesArtificial Organs, EarlyView.
M101 Hemoglobin enhances the mechanical and functional properties of rat heart and diaphragm muscles. Treated muscles exhibit improved contraction, reduced fatigue, and maintained function over time, suggesting potential clinical applications of M101 in preventing ischemia–reperfusion injury.
Ollivier Grimault   +7 more
wiley   +1 more source

Pulmonary Hypertension in COVID-19 Pneumoniae: It Is Not Always as It Seems

open access: yesEuropean Journal of Case Reports in Internal Medicine, 2020
A patient affected by COVID-19 pneumonia may develop pulmonary hypertension (PH) and secondary right ventricular (RV) involvement, due to lung parenchymal and interstitial damage and altered pulmonary haemodynamics, even in non-advanced phases of the ...
Maria Cristina Pasqualetto   +9 more
doaj   +1 more source

Human hypoxia models in aerospace medicine: Potential applications for human pharmacological research

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aerospace medicine required controlled terrestrial models to investigate influences of altered atmosphere conditions, such as hypoxia, on human health and performance. These models could potentially be expanded to encompass disease conditions or treatment targets regulated through hypoxia or hypercapnia.
Titiaan E. Post   +4 more
wiley   +1 more source

Revisiting the Role of TRP, Orai, and ASIC Channels in the Pulmonary Arterial Response to Hypoxia

open access: yesFrontiers in Physiology, 2018
The pulmonary arteries are exquisitely responsive to oxygen changes. They rapidly and proportionally contract as arterial PO2 decrease, and they relax as arterial PO2 is re-established.
Roberto V. Reyes   +9 more
doaj   +1 more source

Connexin 43 plays a role in proliferation and migration of pulmonary arterial fibroblasts in response to hypoxia

open access: yesPulmonary Circulation, 2020
Pulmonary hypertension (PH) is a disease associated with vasoconstriction and remodelling of the pulmonary vasculature. Pulmonary artery fibroblasts (PAFs) play an important role in hypoxic-induced remodelling.
Andrew J. McNair   +4 more
doaj   +1 more source

Mechanisms and clinical translation of high altitudepulmonary edema: current status and future prospects

open access: yes生物医学转化, 2021
High altitude pulmonary edema (HAPE) is a form of life-threatening high altitude idiopathy.This non-cardiogenic pulmonary edema is a serious illness with high risk of morbidity.
Gao Wenxiang   +3 more
doaj   +1 more source

Non‐canonical PKG1 regulation in cardiovascular health and disease

open access: yesBritish Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

Mechanisms maintaining right ventricular contractility-to-pulmonary arterial elastance ratio in VA ECMO: a retrospective animal data analysis of RV–PA coupling

open access: yesJournal of Intensive Care
Background To optimize right ventricular–pulmonary coupling during veno-arterial (VA) ECMO weaning, inotropes, vasopressors and/or vasodilators are used to change right ventricular (RV) function (contractility) and pulmonary artery (PA) elastance ...
Kaspar F. Bachmann   +4 more
doaj   +1 more source

The effects of genetic deletion of Macrophage migration inhibitory factor on the chronically hypoxic pulmonary circulation

open access: yesPulmonary Circulation, 2020
While it is well established that the haemodynamic cause of hypoxic pulmonary hypertension is increased pulmonary vascular resistance, the molecular pathogenesis of the increased resistance remains incompletely understood. Macrophage migration inhibitory
Lili Li   +7 more
doaj   +1 more source

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