Results 91 to 100 of about 4,530 (250)
Limited efficacy of zonisamide in the treatment of refractory infantile spasms
Epilepsia Open, 2020 A series of relatively small studies collectively suggest that zonisamide may be effective in the treatment of infantile spasms. Using a large single‐center cohort of children with infantile spasms, we set out to evaluate the efficacy and safety of ...
Shaun A. Hussain +7 more
doaj +1 more source
RARS2 mutations in a sibship with infantile spasms [PDF]
, 2016 Pontocerebellar hypoplasia is a group of heterogeneous neurodevelopmental disorders characterized by reduced volume of the brainstem and cerebellum.
Bras, J +13 more
core +1 more source
Neuronal oscillatory imbalances in GNAO1‐related disorders associated with disease severity
Epilepsia, EarlyView.Abstract Objective This study investigates excitatory/inhibitory (E/I) imbalances in GNAO1‐related disorders (GNAO1‐RD), linking neuronal dysfunction to clinical severity using E/I‐sensitive electroencephalography (EEG) analyses. Methods We conducted an observational study involving 12 children with GNAO1‐RD caused by pathogenic variants and 36 age ...
Tongyu Wang +8 more
wiley +1 more source
Confirmation of infantile spasms resolution by prolonged outpatient EEGs
Epilepsia Open, 2021 Objective There is no consensus on the type or duration of the posttreatment EEG needed for assessing treatment response for infantile spasms (IS). We assessed whether outpatient electroencephalograms (EEGs) are sufficient to confirm infantile spasms (IS)
Christopher J. Yuskaitis +4 more
doaj +1 more source
Epilepsia, EarlyView.Abstract Objective Developmental and epileptic encephalopathy type 1 (DEE1) is a rare drug‐resistant pediatric epilepsy caused by trinucleotide repeat expansions in the X‐linked ARX gene, leading to elongation of the first polyalanine tract. It presents with early onset tonic seizures or spasms, developmental and cognition delay, and high risk of ...
Lucia Verrillo +9 more
wiley +1 more source
Vigabatrin Monotherapy for Infantile Spasms
Pediatric Neurology Briefs, 1995 The successful management of 21 children with infantile spasms and hypsarrhythmia using vigabatrin monotherapy is reported from the Alder Hey Children’s Hospital, Liverpool, UK.
J Gordon Millichap
doaj +1 more source
Management practices for West syndrome in South Asia: A survey study and meta‐analysis
Epilepsia Open, 2020 Objectives Considering the dearth of literature on West syndrome (WS) from South Asian countries, this study aimed to evaluate the management practices in South Asia by an online survey and meta‐analysis.
Priyanka Madaan +10 more
doaj +1 more source
"Electro-clinical Syndromes" with onset in Paediatric Age. the highlights of the clinical-EEG, genetic and therapeutic advances [PDF]
, 2011 The genetic causes underlying epilepsy remain largely unknown, and the impact of available genetic data on the nosology of epilepsy is still limited.
Alberto Verrotti +7 more
core +2 more sources
Neurology and Clinical Neuroscience, Volume 13, Issue 5, Page 375-378, September 2025.ABSTRACT Interictal focal paroxysmal fast activity is a pattern seen in scalp electroencephalography recordings of patients with epilepsy, but its clinical relevance remains unclear. High‐frequency oscillations, considered a surrogate marker of epileptogenicity, are being studied in relation to scalp electroencephalography. To explore the importance of
Tatsuya Sato +9 more
wiley +1 more source
Pediatric Neurology Briefs, 1990 The relationship between dose of ACTH and the initial effect and long-term prognosis was investigated in 41 children with infantile spasms at the Department of Pediatrics, Kyoto University, Kyoto, Japan.
J Gordon Millichap
doaj +1 more source