Development of the Pyrido[2,3-d]pyrimidin-7(8H)-one Scaffold toward Potent and Selective NUAK1 Inhibitors. [PDF]
Rooney TPC +9 more
europepmc +1 more source
Numerical Investigation of a Diffusive SIR Model: Focus on Positivity Preservation
ABSTRACT In this paper, we consider a system of semilinear partial differential equations (PDEs) representing a spatially extended SIR epidemic model. A brief analytical investigation of the well‐posedness and positivity of the solutions is provided in the appendix, while the main focus is on the numerical treatment of the model.
Rahele Mosleh +2 more
wiley +1 more source
Synthesis and Antitumor Activity of 6-(2-Aminobenzo[d]thiazol-5-yl) quinazolin-4(3H)-one Derivatives. [PDF]
Linghu A +9 more
europepmc +1 more source
Quantifying the Effects of Spatial Inhomogeneity in an Autoclave LDPE Reactor Using CFD
A CFD simulation incorporating rigorous polymerization chemistry into a plant‐scale sliding mesh reactor with multiple PID controllers revealed axial flow patterns that segment the reactor into smaller compartments with different properties. More evident differences exist between the mixture within the agitator shaft swept volume and that outside of ...
Elijah Yoder, Wayne Strasser
wiley +1 more source
Trastuzumab Potentiates Antitumor Activity of Thiopyrano[2,3-d]Thiazole Derivative in AGS Gastric Cancer Cells. [PDF]
Roszczenko P +7 more
europepmc +1 more source
Autonomy for MRI Field Cameras: Synchronization, Self‐Calibration, and Sequence Detection
ABSTRACT Purpose This work aims to provide a workflow for operating NMR field probes in MR scanners independently of pulse programming, scanner TTL trigger pulses and dedicated calibration sequences. Methods An independent timing system and limited prior knowledge about relative probe positions enable synchronous field measurement, probe position ...
Oskar Björkqvist, Klaas P. Pruessmann
wiley +1 more source
ABSTRACT Purpose To characterize the diffusion properties of prostate epithelium and stroma in benign tissue and cancer. Methods Paired MR microscopy (20 μm) and multidimensional diffusion MRI (dMRI) (160 μm, b = 1000–2000 s/mm2, ∆ = 15–120 ms) were performed at 16.4 T on 17 fixed prostate tissue samples (14× benign, 2× Gleason 3 + 3, 1× Gleason 4 + 4).
Adam Phipps +7 more
wiley +1 more source
Mathematical modelling of the influence of ACE I/D polymorphism on blood pressure and antihypertensive therapy. [PDF]
Kutumova E +4 more
europepmc +1 more source
Optimization of Diffusion MRI With Consideration of the Signal Decay in Biological Tissues
ABSTRACT Purpose Devising methodology to characterize and optimize acquisition schemes for biological tissues, such as the prostate, that produce model‐based synthetic diffusion‐weighted images and derived model parameters with predictable SNR improvement. Methods The averaging effect (AE) in synthetic diffusion‐weighted images obtained through fitting
Stefan Kuczera, Stephan E. Maier
wiley +1 more source

