Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
I-convergence in probabilistic n-normed space
Soft Computing, 2012 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Tripathy, Binod Chandra +2 more
openaire +4 more sources
A new notion of convergence on ideal topological spaces
Selecciones Matemáticas, 2020 In this article, we use the notions of b-open and b-I-open sets to introduce the idea of b-I-convergence which we will denoted by b-I-convergence, we also show some of its properties.
Carlos Granados
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Unified Convergence Analysis of Chebyshev–Halley Methods for Multiple Polynomial Zeros
Mathematics, 2022 In this paper, we establish two local convergence theorems that provide initial conditions and error estimates to guarantee the Q-convergence of an extended version of Chebyshev–Halley family of iterative methods for multiple polynomial zeros due to ...
Stoil I. Ivanov
doaj +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Visualizing Convergence Dynamics across Regions and States: h-Convergence
MathematicsResearchers interested in studying whether convergence dynamics are in place among regions within the same country have adopted both statistical tools and empirical frameworks developed when studying convergence across different economies.
Leone Leonida
doaj +1 more source
L 2 convergence of smooth approximations of stochastic differential equations with unbounded coefficients [PDF]
, 2023 Sahani Pathiraja
openalex +1 more source
Asymptotic behavior of two-phase flows in heterogeneous porous media for capillarity depending only on space. I. Convergence to the optimal entropy solution [PDF]
, 2009 We consider an immiscible two-phase flow in a heterogeneous one-dimensional porous medium. We suppose particularly that the capillary pressure field is discontinuous with respect to the space variable.
Cancès, Clément
core +2 more sources
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source