ABSTRACT Background Hereditary Spastic Paraplegia (HSP) comprises a group of rare genetic diseases characterized by length‐dependent axonal degeneration of the corticospinal tracts and dorsal columns, whose main clinical feature is spastic gait. Pathogenic variants in the SPG4 gene cause Spastic Paraplegia Type 4 (SPG4‐HSP), the most common form of HSP.
Gaia Fattorini +12 more
wiley +1 more source
PCGF1 Promotes the Tumorigenesis of Malignancies Through Upregulating CCDC34 in Glioma
ABSTRACT Background Polycomb group factor 1 (PCGF1) and coiled‐coil domain‐containing protein 34 (CCDC34) have been implicated in tumorigenesis in multiple malignancies. However, their biological functions and prognostic significance in glioma remain poorly defined.
Yuanbing Chen +7 more
wiley +1 more source
Influence of head rotation on oropharyngeal leak pressure of LMA-Protector<sup>TM</sup> and i-gel® in paralysed, anaesthetised patients: A randomised comparative study. [PDF]
Sharma G, Dali JS, Soni M, Virmani R.
europepmc +1 more source
β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio +11 more
wiley +1 more source
This study proposes a potential device design for joint cartilage replacement. Silica‐polytetrahydrofuran (SiO2‐PolyTHF) hybrids with customizable mechanical properties were developed to mimic the characteristics of a natural meniscus. These were synthesized through a two‐pot sol–gel hybrid process.
Yu‐Chien Lin +12 more
wiley +1 more source
Effect of airway management method on hypothermia in patients undergoing laparoscopic gynecologic surgery: tracheal intubation, supreme laryngeal mask, and i-gel laryngeal mask. [PDF]
Qi F, Zhang D, Meng Y, Jiang F, Zhang Z.
europepmc +1 more source
A thermoplastic PMMA‐based photoresin enables high‐resolution DLP printing followed by solvent‐vapor smoothing. The treatment reduces staircase‐induced surface roughness from 2.33 µm to 129 nm and increases visible‐light transmittance from approximately 30% to 80%, providing a route toward transparent PMMA components for rapid prototyping and non ...
Rozhin Heydarpour +5 more
wiley +1 more source
In Vitro Characterization of Human Cell Sources in Collagen Type I Gel Scaffold for Meniscus Tissue Engineering. [PDF]
Canciani B +10 more
europepmc +1 more source
Laser‐Induced Graphene from Waste Almond Shells
Almond shells, an abundant agricultural by‐product, are repurposed to create a fully bioderived almond shell/chitosan composite (ASC) degradable in soil. ASC is converted into laser‐induced graphene (LIG) by laser scribing and proposed as a substrate for transient electronics.
Yulia Steksova +9 more
wiley +1 more source
From Food to Power: Hydrogel Thermoelectrics for Ingestible Electronics
We introduce a fully edible thermoelectric–electrochromic platform that harvests heat from food and converts it into a visible color change. N‐type and p‐type hydrogel thermoelectric generators connected in series power anthocyanin‐based electrochromic displays, demonstrating the feasibility of safe, biodegradable, ingestible systems for on‐food ...
Antonia Georgopoulou +3 more
wiley +1 more source

