Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Factors associated with birth satisfaction in Chinese women: a prospective cohort study. [PDF]
Front Public HealthWang Y, Gu J.
europepmc +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Terahertz Time-Domain Spectroscopy as a Defect Fingerprinting Tool for Halide Perovskite Solar Cells: Toward a Universal Framework. [PDF]
Nanomaterials (Basel)Maeng I, Lee YM, Park J, Oh SJ, Jung MC.
europepmc +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Students' Learning Outcomes in a Virtual Microscopic Online and Face-to-Face Anatomy Course: Cross-Over Comparative Study. [PDF]
JMIR Med EducSternecker K, Schmitz C, Berndt M.
europepmc +1 more source
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
Toward a 10 GHz High-Order Surface Acoustic Wave Resonator: A Finite-Element Study on LiNbO<sub>3</sub>/SiC Heterostructure Incorporating Embedded Electrodes. [PDF]
Micromachines (Basel)Wang Y, Li H, Wu Q, Wu T, Zhang Q.
europepmc +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Label-Free Refractive-Index-Based Detection of Breast, Leukemia, and Prostate Cancer Cells Using a Tetra-Core PCF SPR Biosensor. [PDF]
Biosensors (Basel)Shakya AK, Grigalavičius M.
europepmc +1 more source