Results 91 to 100 of about 1,024,799 (290)

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

Evaluating effectiveness of linguistic technologies of knowledge identification in text collections [PDF]

, 2014
The possibility of using integral coefficients of recall and precision to evaluate effectiveness of linguistic technologies of knowledge identification in texts is analyzed in the paper.
Khairova, N. F., Petrasova, S. V., Shepelyov, G.   +2 more
core  

Non-diagonal reflection for the non-critical XXZ model

, 2007
The most general physical boundary $S$-matrix for the open XXZ spin chain in the non-critical regime ($\cosh (\eta)>1$) is derived starting from the bare Bethe ansazt equations.
Anastasia Doikou, Arnaudon D, Baseilhac P Koizumi K, Doikou A, Doikou A, Doikou A, Doikou A, Doikou A, Doikou A, Faddeev L D, Frappat L, Galleas W, Gasper G, Grisaru M T, Klumper A, Korepin V E, Korepin V E, Murgan R, Murgan R, Sklyanin E K, Vega H J de, Yang W-L   +21 more
core   +1 more source

Renal ¹²³I-MIBG Uptake before and after Live-Donor Kidney Transplantation

Diagnostics, 2020
Increased sympathetic activity is suggested to be part of the pathogenesis in several diseases. Methods to evaluate sympathetic activity and renal nervous denervation procedural success are lacking. Scintigraphy using the norepinephrine analog Iodine-123
Thomas Rasmussen, Robin de Nijs, Lene Kjær Olsen, Anne-Lise Kamper, Lia Evi Bang, Marie Frimodt-Møller, Henning Kelbæk, Søren Schwartz Sørensen, Andreas Kjær, Bo Feldt-Rasmussen, Jesper Hastrup Svendsen, Philip Hasbak   +11 more
doaj   +1 more source

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

Is it possible to estimate the Higgs Mass from the CMB Power Spectrum?

, 2009
General Relativity and Standard Model are considered as a theory of dynamical scale symmetry with definite initial data compatible with the accepted Higgs mechanism. In this theory the Early Universe behaves like a factory of electroweak bosons and Higgs
A. B. Arbuzov, A. B. Borisov, A. Borowiec, A. D. Riess, A. D. Sakharov, A. F. Zakharov, A. G. Riess, A. Lichnerowicz, B. M. Barbashov, B. M. Barbashov, B. M. Barbashov, D. Behnke, D. N. Spergel, E. P. Wigner, J. Bernstein, J. F. Gunion, L. A. Glinka, L. B. Okun, M. E. Shaposhnikov, M. Giovannini, M. Pawlowski, P. A. M. Dirac, P. A. M. Dirac, R. H. Cyburt, S. A. Shuvalov, S. A. Smolyansky, V. N. Pervushin, V. N. Pervushin, V. Pervushin, W. Hu   +29 more
core   +1 more source

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source

Edisto Inlet as a sentinel for Late Holocene environmental changes over the Ross Sea: insights from foraminifera turnover events [PDF]

Climate of the Past
Identifying marine environmental changes is important to understand the processes that govern the Earth's climate system and its interacting components.
G. Galli, G. Galli, K. E. Hansen, C. Morigi, A. Di Roberto, F. Giglio, P. Giordano, K. Gariboldi   +7 more
doaj   +1 more source

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source