Results 121 to 130 of about 1,024,799 (290)

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani, Lakshmi Pillai, Reid D. Landes, Aliyah Glover, Shannon Doerhoff, Jennifer Kleiner, Mitesh Lotia, Rohit Dhall, Edgar Garcia‐Rill   +8 more
wiley   +1 more source

Black hole and nuclear cluster scaling relations: M_bh ∝ M_nc^2.7±0.7 [PDF]

, 2014
Alister W. Graham
openalex   +1 more source

2.7 kV Low Leakage Vertical PtO_x/β-Ga₂O₃ Schottky Barrier Diodes With Self-Aligned Mesa Termination [PDF]

, 2023
Zhao Han, Guangzhong Jian, Xuanze Zhou, Qiming He, Weibing Hao, Jinyang Liu, Botong Li, Hong Huang, Qiuyan Li, Xiaolong Zhao, Guangwei Xu, Shibing Long   +11 more
openalex   +1 more source

Predicting Epileptogenic Tubers in Patients With Tuberous Sclerosis Complex Using a Fusion Model Integrating Lesion Network Mapping and Machine Learning

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Accurate localization of epileptogenic tubers (ETs) in patients with tuberous sclerosis complex (TSC) is essential but challenging, as these tubers lack distinct pathological or genetic markers to differentiate them from other cortical tubers.
Tinghong Liu, Qi Wang, Suhui Kuang, Dezhi Cao, Ping Ding, Shaohui Zhang, Haihua Wei, Zhirong Wei, Jinshan Xu, Xinyu Huang, Bing Liu, Shuli Liang   +11 more
wiley   +1 more source

Characteristic crossing point (T_*≈2.7 K) in specific heat curves of samples RuSr₂Gd_1.5Ce_0.5Cu₂O_10−δtaken for different values of magnetic field [PDF]

, 2009
B I Belevtsev, V B Krasovitsky, D G Naugle, K D D Rathnayaka, G Agnolet, I Felner   +5 more
openalex   +1 more source

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

Bayesian Estimation Improves Prediction of Outcomes After Epilepsy Surgery

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT We estimated the statistical power of studies predicting seizure freedom after epilepsy surgery. We extracted data from a Cochrane meta‐analysis. The median power across all studies was 14%. Studies with a median sample size or less (n ≤ 56) and a statistically significant result exaggerated the true effect size by a factor of 5.4, while the ...
Adam S. Dickey, Vineet Reddy, Ammar A. Rashied, Nigel P. Pedersen, Robert T. Krafty   +4 more
wiley   +1 more source

Direct dark matter search by annual modulation with 2.7 years of XMASS-I data [PDF]

, 2018
K. Abe, K. Hiraide, K. Ichimura, Y. Kishimoto, Kazuyoshi Kobayashi, M. Kobayashi, S. Moriyama, M. Nakahata, T. Norita, Hiroshi Ogawa, K. Satô, H. Sekiya, O. Takachio, A. Takeda, S. Tasaka, M. Yamashita, B. S. Yang, N. Y. Kim, Young Dong Kim, Y. Itow, K. Kanzawa, R. Kegasa, K. Masuda, H. Takiya, K. Fushimi, G. Kanzaki, K. Martens, Y. Suzuki, Benda Xu, R. Fujita, K. Hosokawa, K. Miuchi, Natsuhisa Oka, Y. Takeuchi, Y. H. Kim, K. B. Lee, M. K. Lee, Y. Fukuda, M. Miyasaka, K. Nishijima, Shogo Nakamura   +40 more
openalex   +1 more source

ALS With and Without Upper Motor Neuron Signs: A Comparative Study Supporting the Gold Coast Criteria

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The Gold Coast criteria permit diagnosis of amyotrophic lateral sclerosis (ALS) even without upper motor neuron (UMN) signs. However, whether ALS patients with UMN signs (ALSwUMN) and those without (ALSwoUMN) share similar characteristics and prognoses remains unclear.
Hee‐Jae Jung, E‐nae Cheong, Jungmin So, Heung‐Won Kang, Yangsean Choi, Eun‐Jae Lee, Hyunjin Kim, Young‐Min Lim   +7 more
wiley   +1 more source