Results 71 to 80 of about 1,024,799 (290)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Characterization and Antimicrobial Susceptibility Patterns of Enterococcus Species Isolated from Nosocomial Infections in a Saudi Tertiary Care Hospital over a Ten-Year Period (2012–2021)

Diagnostics
Introduction: The Enterococcus genus is a common cause of nosocomial infections, with vancomycin-resistant enterococci (VRE) posing a significant treatment challenge.
Ali Al Bshabshe, Abdullah Algarni, Yahya Shabi, Abdulrahman Alwahhabi, Mohammed Asiri, Ahmed Alasmari, Adil Alshehry, Wesam F. Mousa, Nashwa Noreldin   +8 more
doaj   +1 more source

Search for variable stars in the young open cluster Stock 18

EPJ Web of Conferences, 2017
We have carried out multi-epoch deep I band photometry of the open cluster Stock 18 to search for variable stars in star forming regions. In the present study, we report identification of 28 periodic and 165 non-periodic variables stars.
Sinha Tirthendu, Sharma Saurabh, Pandey Rakesh, Pandey A.K.   +3 more
doaj   +1 more source

Investigation of Age Gelation in UHT Milk

Beverages, 2018
Milk samples with twelve combinations of κ- and β-casein (CN) and β-lactoglobulin (β-Lg) variants were obtained to investigate the effect of protein variant on the mechanism/s of age gelation in ultra-high temperature (UHT) skim milk.
Jared K. Raynes, Delphine Vincent, Jody L. Zawadzki, Keith Savin, Dominik Mertens, Amy Logan, Roderick P.W. Williams   +6 more
doaj   +1 more source

Influence of Varying Dietary ω6 to ω3 Fatty Acid Ratios on the Hepatic Transcriptome, and Association with Phenotypic Traits (Growth, Somatic Indices, and Tissue Lipid Composition), in Atlantic Salmon (Salmo salar)

Biology, 2021
The importance of dietary omega-6 to omega-3 (ω6:ω3) fatty acid (FA) ratios for human health has been extensively examined. However, its impact on fish physiology, and the underlying molecular mechanisms, are less well understood. This study investigated
Tomer Katan, Xi Xue, Albert Caballero-Solares, Richard G. Taylor, Christopher C. Parrish, Matthew L. Rise   +5 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

The Role of Final State Interactions in Quasielastic $^{56}$Fe$(e,e')$ Reactions at large $|\vec q|$

, 1994
A relativistic finite nucleus calculation using a Dirac optical potential is used to investigate the importance of final state interactions [FSI] at large momentum transfers in inclusive quasielastic electronuclear reactions.
A. Picklesimer, C. J. Horowitz, C. J. Horowitz, C. R. Chinn, C. R. Chinn, C. R. Chinn, C. R. Chinn, C. R. Chinn, Ch. Elster, G. Co', H. Kim, H. W. L. Naus, J. F. Berger, J. P. Chen, J. R. Shepard, M. A. Franey, M. Gari, M. R. Frank, M. V. Hynes, P. C. Tiemeijer, R. D. Smith, R. Machleidt, S. A. Chin, S. Fantoni, Y. Horikawa, Z. E. Meziani   +25 more
core   +1 more source

The decay $$B\rightarrow K+\nu +\bar{\nu }$$ B → K + ν + ν ¯ at Belle II and a massless bino in R-parity-violating supersymmetry

European Physical Journal C: Particles and Fields
Recently, Belle II announced evidence for the decay $$B^+\rightarrow K^+ +\nu +\bar{\nu }$$ B + → K + + ν + ν ¯ at the $$3.5\,\sigma $$ 3.5 σ significance, and measured the corresponding decay branching ratio to be $$2.7\,\sigma $$ 2.7 σ above the ...
Zeren Simon Wang, Herbert K. Dreiner, Julian Y. Günther   +2 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

The branching structure of diffusion-limited aggregates

, 1997
I analyze the topological structures generated by diffusion-limited aggregation (DLA), using the recently developed "branched growth model". The computed bifurcation number B for DLA in two dimensions is B ~ 4.9, in good agreement with the numerically ...
, Eyrolles G., Eyrolles G., Hinrichsen E. L., Strahler A. N., T. C Halsey, Tokunaga E., Vannimenus J., Yekutieli I.   +8 more
core   +2 more sources