Results 81 to 90 of about 1,024,799 (290)
Crystal structure of an adenovirus virus-associated RNA
Nature Communications, 2019 Adenovirus Virus-Associated (VA) noncoding RNAs interfere with the host system by mimicking double stranded RNAs. Here, the authors report a 2.7 Å crystal structure of VA-I RNA providing an understanding of its function.
Iris V. Hood +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
DiversityGlobalization has greatly expanded the opportunities for plant species to enter new areas through a wide range of pathways. Elucidating the pathways of spread of alien species and the characteristics of organisms that make them invasive is one of the ...
Eugenija Kupcinskiene +7 more
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Structural Defects in TiNi-Based Alloys after Warm ECAP
Metals, 2020 The microstructure, martensitic transformations and crystal structure defects in the Ti50Ni47.3Fe2.7 (at%) alloy after equal-channel angular pressing (ECAP, angle 90°, route BC, 1–3 passes at T = 723 K) have been investigated.
Aleksandr Lotkov +4 more
doaj +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Freudenthal Duality and Generalized Special Geometry
, 2011 Freudenthal duality, introduced in L. Borsten, D. Dahanayake, M. J. Duff and W. Rubens, Phys.Rev. D80, 026003 (2009), and defined as an anti-involution on the dyonic charge vector in d = 4 space-time dimensions for those dualities admitting a quartic ...
Ferrara, Sergio +2 more
core +1 more source
HSP70 governs permeability and mechanotransduction in primary human endothelial cells
FEBS Open Bio, EarlyView.HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez +5 more
wiley +1 more source
Discrete Light-Cone Quantization in PP-Wave Background
, 2005 We discuss the discrete light-cone quantization (DLCQ) of a scalar field theory on the maximally supersymmetric pp-wave background in ten dimensions. It has been shown that the DLCQ can be carried out in the same way as in the two-dimensional Minkowski ...
Bak +31 more
core +1 more source