Results 41 to 50 of about 285,953 (300)

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Surgical Clipping of Previously Coiled Recurrent Intracranial Aneurysms: A Single-Center Experience

Frontiers in Neurology, 2021
Objective: This study reviews our experiences in surgical clipping of previously coiled aneurysms, emphasizing on recurrence mechanism of intracranial aneurysms (IAs) and surgical techniques for different types of recurrent IAs.Method: We performed a ...
Yongtao Zheng, Lili Zheng, Yuhao Sun, Dong Lin, Baofeng Wang, Qingfang Sun, Liuguan Bian   +6 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Effects of arsenic on porcine dendritic cells in vitro

Journal of Immunotoxicology, 2017
Exposure to arsenic (As) is an ongoing, and in some places increasing, health problem. Still, however, the effects of As exposure on the immune system are not well understood.
Jalil Mehrzad, Mohamad Hosein Mahmudy Gharaie, Masumeh Taheri   +2 more
doaj   +1 more source

ANALYSE DE L'EFFET DES IMPOTS DIFFERES SUR LE CONTENU INFORMATIONNEL DU RESULTAT : CAS DES FIRMES UTILISANT LES NORMES INTERNATIONALES ET LES NORMES AMERICAINES [PDF]

, 2008
International audienceL'objectif de ce papier est d'analyser l'effet des impôts différés sur le contenu informationnel du résultat pour deux échantillons de firmes se référant aux normes IAS/IFRS et aux US GAAP sur une période de dix ans (1994-2003).
Olivero, Bernard, Sbei Trabelsi, Nadia
core   +1 more source

Brain Activity Mapping from MEG Data via a Hierarchical Bayesian Algorithm with Automatic Depth Weighting [PDF]

, 2018
A recently proposed iterated alternating sequential (IAS) MEG inverse solver algorithm, based on the coupling of a hierarchical Bayesian model with computationally efficient Krylov subspace linear solver, has been shown to perform well for both ...
Calvetti, Daniela, Pascarella, Annalisa, Pitolli, Francesca, Somersalo, Erkki, Vantaggi, Barbara   +4 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Intervention with self-suggestive procedures for self-efficacy and pain control [PDF]

, 2013
Introdução – A dor predomina em muitas patologias médicas e acarreta diversas implicações para o doente. O presente estudo visou avaliar a eficácia de uma intervenção autossugestiva, como complemento ao tratamento médico, no aumento da autoeficácia e ...
Joyce-Moniz, Luís, Pires, Ana F.
core  

Symmetry Energy II: Isobaric Analog States

, 2013
Using excitation energies to isobaric analog states (IAS) and charge invariance, we extract nuclear symmetry coefficients, from a mass formula, on a nucleus-by-nucleus basis.
Aboussir, Agrawal, Agrawal, Akmal, Antony, Baglin, Baglin, Baglin, Bartel, Beiner, Bender, Bennour, Blachot, Blatt, Bodmer, Brown, Brown, Bäckman, Cameron, Cao, Carbone, Carbone, Centelles, Centelles, Chabanat, Chabanat, Chabanat, Chamel, Chamel, Chen, Chen, Chen, Clark, Côté, Danielewicz, Danielewicz, Danielewicz, Danielewicz, Danielewicz, de Frenne, de Shalit, Dieperink, Dobaczewski, Dobaczewski, Dutra, Engel, Farine, Farine, Friedman, Friedrich, Gandolfi, Giai, Giannoni, Gibbs, Gils, Gomez, Goriely, Goriely, Goriely, Goriely, Goriely, Goriely, Goriely, Goriely, Groote, Gross-Boelting, Guichon, Hebeler, Hellemans, Hellemans, Hohenberg, Horowitz, Isayev, Janecke, Janecke, Janecke, Jaqaman, Jenny Lee, Kanbe, Kirson, Klimkiewicz, Klüpfel, Ko, Kohler, Kohler, Kolomietz, Kortelainen, Koura, Koura, Krivine, Kutschera, Lattimer, Lattimer, Lee, Lesinski, Lesinski, Li, Li, Li, Liu, Macchiavelli, Margueron, Mendoza-Temis, Myers, Möller, Nayak, Nazarewicz, Nix, Onsi, Oyamatsu, Pawel Danielewicz, Pearson, Pearson, Pearson, Pearson, Pethick, Piekarewicz, Pines, Rashdan, Ray, Rayet, Reinhard, Reinhard, Reinhard, Reinhard, Reinhard, Rikovska Stone, Ringle, Roca-Maza, Russotto, Samyn, Samyn, Sarriguren, Satula, Sharma, Shimoura, Shlomo, Singh, Singh, Skyrme, Skyrme, Starodubsky, Steiner, Steiner, Stone, Takeuchi, Taranto, Ter-Akopian, Tondeur, Tondeur, Tondeur, Treiner, Trippa, Tsang, Tsang, Tuli, van Giai, van Kolck, Vautherin, Vidaña, Vogel, Vuong, Wang, Wiringa, Zeldes, Zenihiro, Zhang, Zhang   +167 more
core   +1 more source

Predictors of course and outcome in hypochondriasis after cognitive-behavioral treatment [PDF]

, 2002
Background. Predictors of treatment outcome were evaluated in a clinical sample suffering from hypochondriasis. Methods: The sample consisted of 96 patients with hypochondriacal disorder according to DSM-IV or high syndrome scores on the Illness Attitude
Fichter, Manfred M., Hiller, Wolfgang, Leibbrand, Rolf, Rief, Winfried   +3 more
core   +1 more source