Results 171 to 180 of about 266,769 (304)

Nonviral Gold Nanoparticle‐Mediated Delivery of CRISPR‐Cas9 Ribonucleoprotein and Long DNA Transgenes Into Primary Blood Cells

Advanced NanoBiomed Research, EarlyView.
CRISPR/Cas9 has revolutionized the field of gene therapy, but delivery remains an outstanding issue. We propose a nonviral gold‐nanoparticle platform for co‐delivery of CRISPR/Cas9 ribonucleoprotein and long 2.1 kilobase dsDNA transgene constructs. This CRISPR‐AuNP is inexpensive to produce and mediate gene editing and DNA delivery in T cells and CD34+
Rachel A. Cunningham, Karthikeya S. V. Gottimukkala, Daniel D. Lane, Katrina Poljakov, Patricia Lipson, Mark R. Enstrom, Alessandro Rizzi, Aude G. Chapuis, Jennifer E. Adair   +8 more
wiley   +1 more source

A multicenter hemodynamics-based nomogram predicting incomplete occlusion of intracranial aneurysms treated with pipeline embolization device. [PDF]

Front Neurol
Zhao Y, Bao L, He S, Zhang Y.
europepmc   +1 more source

Protein‐Driven Copper Redox Regulation: Uncovering the Role of Disulphide Bonds and Allosteric Modulation

Angewandte Chemie International Edition, EarlyView.
Copper binding triggers structural changes that expose a reactive disulphide bridge, enabling intrinsic Cu(II) reduction in folded proteins. SAXS, XAS, and QM/MM simulations reveal how globular proteins such as HSA and SOD1 employ disulphide‐mediated dynamics to modulate site accessibility and control copper redox chemistry.
Rebecca Sternke‐Hoffmann, Chang Liu, Xue Wang, Hegne Pupart, Xun Sun, Jan Gui‐Hyon Dreiser, Peep Palumaa, Qinghua Liao, Matthias Krack, Jinghui Luo   +9 more
wiley   +1 more source

Analysis of symptomatic brain aneurysms with three-dimensional aneurysm wall enhancement. [PDF]

Neurosurg Rev
Zhu C, Sagues E, Tian B, Zhao H, Gudino A, Shenoy N, Ojeda D, Dier C, Saleem A, Wendt L, Sanchez S, Miller JM, Noboa L, Guijarro-Falcon K, Jones MT, Krug R, Ortega-Gutierrez S, Hasan D, Samaniego EA.   +18 more
europepmc   +1 more source

Финансовая аренда в финансовой отчетности арендаторов в соответствии с IAS 17 «Аренда»

Международный бухгалтерский учет, 2011
В статье приводится понятие финансовой аренды, порядок признания финансовой аренды у арендатора и ее раскрытия в финансовой отчетности арендатора в соответствии с международным стандартом, а также расчет распределения процентных платежей по финансовой аренде и амортизационных отчислений по арендуемым активам.
openaire   +1 more source

The coelurosaur theropods of the Romualdo formation, early Cretaceous (Aptian) of Brazil: Santanaraptor placidus meets Mirischia asymmetrica

The Anatomical Record, EarlyView.
Abstract The upper carbonate concretion levels of the Romualdo Formation (Aptian, Brazil) have yielded several theropod dinosaur remains, including spinosaurids and the coelurosaurs Santanaraptor placidus and Mirischia asymmetrica, the phylogenetic affinities of which are controversial.
Rafael Delcourt, Orlando Nelson Grillo, Christophe Hendrickx, Maximilian Kellermann, Max Cardoso Langer   +4 more
wiley   +1 more source

Safety and Efficacy of the LVIS EVO Device for Stent-Assisted Coiling of Intracranial Aneurysms: A Systematic Review and Meta-Analysis. [PDF]

J Clin Med
Alrasheed AS, Elazrag AM, Alseghair RH, Alasmari MN, Alqahtani MS, Al-Jehani H.   +5 more
europepmc   +1 more source

Does salinity make a difference—Kidney anatomy of Saimaa (Pusa saimensis) and Baltic ringed seals (Pusa hispida botnica)

The Anatomical Record, EarlyView.
Abstract As habitat salinity markedly differs between the endangered, freshwater‐dwelling Saimaa ringed seal (Pusa saimensis Nordquist, 1899) and the brackish water‐inhabiting Baltic ringed seal (Pusa hispida botnica Gmelin, 1788), we investigated whether this difference has resulted in morphological changes to their kidneys.
Heini Nihtilä, Juha Laakkonen
wiley   +1 more source

Transseptal Puncture for Left Atrial Appendage Closure: A Consensus Document From the Second European Left Atrial Appendage Club. [PDF]

J Soc Cardiovasc Angiogr Interv
Rosseel L, Wunderlich NC, Berti S, Aminian A, Nielsen-Kudsk JE, Cruz-Gonzalez I, Räber L, Nombela-Franco L, Shuvy M, Freixa X, Garot P, De Backer O.   +11 more
europepmc   +1 more source

IAS 17 -standardin käyttöönoton vaikutukset toimintaedellytysten arviointiin pienissä ja keskisuurissa yrityksissä

, 2009
Tutkielma käsittelee IAS 17 -standardin käyttöönoton vaikutuksia pienten ja keskisuurten yritysten toimintaedellytyksiin. Tutkielma toteutetaan Suomen kirjanpitolain ja IAS 17 -standardin kirjaustapaerojen vaikutuksien tutkimisella yrityksen tilinpäätöksestä laskettaviin tunnuslukuihin.
openaire   +1 more source