Results 81 to 90 of about 10,417 (244)

AKAP1 Protects Retinal Ganglion Cells and Preserves Vision by Improving Mitochondrial and Synaptic Health in Glaucomatous Neurodegeneration

Advanced Science, EarlyView.
Intravitreal AAV2‐mediated AKAP1 restoration enhances mitochondrial fusion and biogenesis, improves bioenergetic capacity, and preserves mitochondrial integrity in glaucomatous RGCs. AKAP1 stabilizes presynaptic structure, maintaining synaptic protein expression, and limiting complement‐associated neuroinflammation.
Tonking Bastola, Keun‐Young Kim, Ziyao Shen, Guy A. Perkins, Muna Poudel, Yoonjin Lim, Hyejeong Choi, Soo‐Ho Choi, Mark H. Ellisman, Robert N. Weinreb, Won‐Kyu Ju   +10 more
wiley   +1 more source

Criterios de medición y revelación de la NIC 41 aplicados por empresas peruanas y chilenas.

Teuken Bidikay, Revista Latinoamericana de Investigación en Organizaciones Ambiente y Sociedad, 2017
La actividad agrícola tiene un importante papel en las economías peruana y chilena. La aplicación de la NIC 41 ha originado el establecimiento de nuevos criterios de medición por parte de las empresas agrícolas, debido, principalmente, a la aplicación ...
Julio Hernández, Ivette Núñez, Diana Zapata   +2 more
doaj  

Comparative Evaluation of Chelator‐Conjugated Peptides for Lead‐Labeled SSTR2‐Targeted Theranostics: Integrated Computational Modeling and Preclinical Validation

Advanced Science, EarlyView.
The study integrates density functional theory with radiochemical and biological validation to compare DOTA‐, PSC‐, and DOTAM‐based chelator‐conjugates for 203Pb/212Pb theranostic applications. Distinct differences in metal coordination, electrostatic properties, conformational flexibility, cellular uptake, biodistribution, and dosimetry are identified
Jeongyun Kim, Na Yeon Han, Ayman Muzammal, Jae Hun Ahn, Changkeun Im, Sujin Kim, Sairan Eom, Choong Mo Kang, Ku Kang, Yong Jin Lee, Kyo Chul Lee, Michael K. Schultz, Dongyoul Lee   +12 more
wiley   +1 more source

In Vivo CRISPR Screen Identifies RPS19 as an Immunotherapy Target in Hepatocellular Carcinoma

Advanced Science, EarlyView.
By employing in vivo CRISPR functional screening, we identify ribosomal protein RPS19 as a pivotal mediator driving immune evasion in hepatocellular carcinoma, wherein tumor‑released RPS19 binds C5aR1 on tumor‑associated macrophages to initiate downstream immunosuppressive signaling; SP94‑peptide‑modified SNPSS nanoparticles deliver Cas9/sgRPS19 ...
Lei He, Duo Yu, Fei Xie, Kaisheng Hou, Zhaozhao Li, Meifang Dai, Jingyi Yun, Haiyan Cao, Yang Xiao, Yueyuan Qiu, Gege Shi, Wangqian Zhang, Shuning Wang, Qiang Hao, Jieyu Zhang, Zhaowei Wang, Yingqi Zhang, Kuo Zhang, Jintao Gu, Haichen Du, Meng Li   +20 more
wiley   +1 more source

Early‐Life Polyethylene Microplastic Exposure Exacerbates ADHD‐Like Behaviors in Mice via PI3K/AKT1/Nrf2 Signaling: Evidence From the Pilot Cohort and Multi‐Omics Analyses

Advanced Science, EarlyView.
Circulating polyethylene microplastic burden is positively associated with heightened ADHD symptom severity and systemic redox‐inflammatory imbalance in children. Mechanistic investigation in a developmental co‐exposure mouse model further demonstrates that microplastics aggravate ADHD‐like behaviors, dopaminergic dysregulation, and oxidative ...
Yufan Luo, Ruijin Xie, Hua Xu, Xue Xiao, Wei Xiao, Qiyang Pan, Shengjie Xu, Li Liu, Zeliang Xiao, Yue Zhou, Chenyu Sun, Yu Wu, Yueying Liu   +12 more
wiley   +1 more source

VALUATION FOR BIOLOGICAL ASSETS WITH HISTORICAL COST ACCOUNTING OR FAIR VALUE ACCOUNTING ? [PDF]

Challenges of the Knowledge Society, 2017
The valuation for biological assets is regulated by IAS 41. Interesting debate is what valuation models it is better to use: historical cost accounting or fair value accounting? I will discuss advantages and disadvantages in this case.
Valentin Gabriel CRISTEA
doaj  

Fully Integrated Wearable Ultrasound System for Continuous Promotion of Wound Healing

Advanced Science, EarlyView.
A wearable ultrasound system integrating a drug‐loaded patch and a miniaturized driving circuit is presented to achieve noninvasive, on‐demand stimulation, enabling programmable antibacterial activity, inflammation modulation, and accelerated wound closure through enhanced cell migration and collagen remodeling.
Faxing Zou, Yansen Wang, Yong Luo, Wenxuan Zhuang, Mingyu Zhu, Min Long, Qingzhou Liu, Tailin Xu   +7 more
wiley   +1 more source

Värdering av skogsfastigheter enligt IAS 41

, 2007
IAS 41 är en värderingsstandard för Jord- och skogsbrukstillgångar. Detta innebär att alla jord- och skogsbrukstillgångar ska redovisas till verkligt värde vid varje bokslutstillfälle. IAS 41 har funnits sedan tidigare men sedan IASC blev IASB så har den reviderats. Den har både fått visst nytt innehåll samt en del av det gamla har behållits.
Gruvholm, Maria, Wester, Andreas
openaire   +1 more source

Hierarchical Organization of Biomaterials in the Formation of Photonic Nanostructures

Advanced Science, EarlyView.
Natural organisms create vibrant structural colors through precisely organized nanostructures formed under mild biological conditions. This review explores how cellulose, chitin, corneous beta‐protein, and melanin form complex nanostructures across molecular, mesoscale, and tissue levels.
Sangyeop Kim, Jihun Kang, Seunghwan Moon, Liliana D'Alba, Matthew D. Shawkey, Jong‐Souk Yeo   +5 more
wiley   +1 more source

The Impact of Cobalt Substitution on the Electrochemical Properties of Cubic Li6.6La3Zr1.6Ta0.4O12 Solid Electrolyte for All‐Solid‐State Li‐Ion Batteries

Advanced Science, EarlyView.
Cobalt is incorporated more readily into garnet Li6.6La3Zr1.6Ta0.4O12 when sintered in argon than in air. Under argon, Co in the garnet lattice lowers the total conductivity three‐ to fourfold; in air, Co segregates as LiCoO2 and raises the electronic conductivity about 100‐fold instead.
Jehad Ahmed, Jordan A. Barr, Zhizhen Qin, Anna Domgans, Kwangnam Kim, Chih‐Long Tsai, Roland Schierholz, Julian Borowec, Brandon C. Wood, Liwen F. Wan, Anna Windmüller, Florian Hausen, Rüdiger Eichel   +12 more
wiley   +1 more source