Results 141 to 150 of about 390,111 (338)

BRAQUIí­Å¡ROS (CRUSTACEA, DECAPODA) DOS SEDIMENTOS SUBLITORAIS DA PRAIA DA ENDEADA, UBATUBA (SP)

open access: yesBoletim do Instituto de Pesca, 2018
A ocorrência de caranguejos no sedimento sublitoral da Praia da Enseada, Ubatuba (SP), foi analisada, comparativamente, em três estações de coleta.
Maria Lucia NEGREIROS-FRANSOZO   +2 more
doaj  

MEOX1 Coordinates Autocrine‐Paracrine Programs via SPHK1/S1P to Promote Lymph Node Metastasis in Ovarian Cancer

open access: yesAdvanced Science, EarlyView.
In ovarian cancer, MEOX1 activates the SPHK1/S1P pathway to promote both tumor progression and tumor–stroma crosstalk. MEOX1‐dependent signaling drives CAF activation, enhances VEGF‐C expression, and stimulates lymphangiogenesis, ultimately facilitating lymph node metastasis.
Jiajia Li   +10 more
wiley   +1 more source

Multimodal Imaging Reveals Rapid Catecholamine Uptake and Release by Neutrophils

open access: yesAdvanced Science, EarlyView.
We show that immune cells (neutrophils) synthesize, uptake, and store catecholamine neurotransmitters such as dopamine or adrenaline. They also release them in response to specific stimuli (serotonin), which we directly visualize using fluorescent nanosensors. We further demonstrate that catecholamines affect neutrophil functions (NETosis) and platelet
Jennifer Mohr   +19 more
wiley   +1 more source

Pembrolizumab in Patients With Advanced Triple-Negative Breast Cancer: Phase Ib KEYNOTE-012 Study.

open access: yesJournal of Clinical Oncology, 2016
R. Nanda   +11 more
semanticscholar   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

open access: yesAdvanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li   +7 more
wiley   +1 more source

Drug‐Induced Cuproptosis Defines the Therapeutic Window of Celecoxib in Intervertebral Disc Degeneration via the HSP90‐RBX1 Axis

open access: yesAdvanced Science, EarlyView.
This study reveals the dual role of celecoxib in intervertebral disc degeneration. While low concentrations are protective, high concentrations induce toxicity by upregulating HSP90, which synergizes with USP15 to deubiquitinate and stabilize RBX1. This leads to degradation of COMMD1/ATP7B, copper dyshomeostasis, and ultimately, cuproptosis.
Youfeng Guo   +11 more
wiley   +1 more source

37. Ephedraceae [PDF]

open access: yes, 2009
En taxonomisk revision af og floristisk redgørelse for alle arter af den nøgenfrøede familie Ephedraceae i Etiopien og EritreaA taxonomic and floristic account of all species in the gymnosperm family Ephedraceae recorded from Ethiopia and ...
Friis, Ib
core  

ZDHHC18‐Mediated Palmitoylation of ORF3a Promotes SARS‐CoV‐2 Pathogenesis by Antagonizing TRIM16‐Mediated Ubiquitination and Proteasomal Degradation

open access: yesAdvanced Science, EarlyView.
Palmitoylation by ZDHHC18 blocks ORF3a K27‐linked ubiquitination mediated by TRIM16, thereby preventing its proteasomal degradation and strengthening viral pathogenesis. Targeting palmitoylation through a pharmacological inhibitor (2‐BP), a competitive inhibitory peptide (OPIP), or adenovirus‐mediated knockdown of ZDHHC18 expression presents a ...
Sidi Yang   +17 more
wiley   +1 more source

26. Thelypteridaceae [PDF]

open access: yes, 2009
En taxonomisk revision af og en floristisk redegørelse for alle arter af bregnefamilien Thelypteridaceae i Etiopien og EritreaA taxonomic revision and a floristic account of all species of the fern family Thelypteridaceae recorded from Ethiopia and ...
Friis, Ib
core  

O Jovem Infrator na Visão dos Profissionais da Febem – Rio Claro

open access: yesEducação: Teoria e Prática, 2007
The present article intends how the professionals that act togegher of offender youngs, perceive that the motives (causes) that take them to that situation, opposing those perceptions to the bibliographical studies.
Patricia Cristina Rosalen   +1 more
doaj  

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