Results 121 to 130 of about 161,924 (219)

Thermotolerant D‐Hydantoinases for Efficient and Stereoselective Intermediate Synthesis of (R)‐3‐Isobutylglutaric Acid Monoamide, a Key Intermediate in Pregabalin Production

Microbial Biotechnology, Volume 19, Issue 3, March 2026.
We engineered thermo‐alkali‐stable D‐hydantoinases via mutagenesis (M63A/F65H/C317T) to resolve Pregabalin's challenging chiral splitting, achieving ee value > 97% for key intermediate (R)‐3‐isobutylglutaric acid monoamide (R‐IBM) synthesis under extreme conditions (pH 10, 70°C–80°C).
Jiujiuzi Zhang, Bin Zhi, Zhenyu Xie, Beibei Zhang, Ning Wang, Wanpeng Wang   +5 more
wiley   +1 more source

Engaging Gut‐to‐Brain Signalling to Treat Alcohol Use Disorder

Addiction Biology, Volume 31, Issue 3, March 2026.
ABSTRACT According to the 2023 National Survey on Drug Use and Health (NSDUH), 28.9 million people ages 12 and older in the United States had alcohol use disorder (AUD) in the past year. Although chronic alcohol use contributes to numerous health disorders as well as being an economic burden, there are few medications approved for treatment of AUD, and
Paula L. Hoffman, Giordano de Guglielmo, Valentina Vengeliene, Wolfgang Kunze, Christina L. Lebonville, Jerome D. Swinny, Amanda J. Roberts, Olivier George, Karen‐Anne McVey Neufeld, Alexandra Dunbar, Laura M. Saba, Ruolin Ma, Leandro F. Vendruscolo, Howard C. Becker, Rainer Spanagel, Boris Tabakoff   +15 more
wiley   +1 more source

Noise Spectroscopy of Liquid–Solid Interface Processes in Adjusted Physiological Solutions Using GAA Si Nanowire FET Biosensors

Advanced Sensor Research
Liquid gate‐all‐around (LGAA) field‐effect transistor (FET) biosensors represent advanced material device structures responding electrically to surface potential change and allowing ultra‐high sensitivity to biochemical liquids and human bodily fluids ...
Yongqiang Zhang, Nazarii Boichuk, Denys Pustovyi, Hanlin Long, Valeriia Chekubasheva, Mykhailo Petrychuk, Svetlana Vitusevich   +6 more
doaj   +1 more source

Trauma‐informed practice for children and young people with intellectual disabilities: A scoping review

British Journal of Educational Psychology, Volume 96, Issue 1, Page 207-239, March 2026.
Abstract Background There is growing consensus that children and young people (CYP) with an intellectual disability are more likely to experience trauma than those in the general population, which can exacerbate their vulnerabilities and developmental challenges.
Claire Wilson, Zara P. Brodie, Kirsten Russell   +2 more
wiley   +1 more source

Peculiarities of the SCLC Effect in Gate‐All‐Around Silicon Nanowire Field‐Effect Transistor Biosensors

Advanced Electronic Materials
High‐quality liquid gate‐all‐around (LGAA) silicon nanowire (NW) field‐effect transistor (FET) biosensors are fabricated and studied their properties in 1 mm phosphate‐buffered saline solution with pH = 7.4 using transport and noise spectroscopy.
Yongqiang Zhang, Nazarii Boichuk, Denys Pustovyi, Valeriia Chekubasheva, Hanlin Long, Mykhailo Petrychuk, Svetlana Vitusevich   +6 more
doaj   +1 more source

Nuevas observaciones de Bubulcus ibis ibis en Colombia

Caldasia, 1955
Hace poco más de un año (*) publiqué unas breves notas acerca de la rápida propagación de la garza Bubulcus ibis ibis (Linn.) en el continente americano, e hice particular referencia a Colombia citando las localidades donde se ha coleccionado o señalado esta interesante ardeida cuyo origen es del Viejo Mundo.
openaire   +2 more sources

Association between glucagon‐like peptide‐1 receptor agonists and risk of dementia in older adults with type 2 diabetes: A target trial emulation

Diabetes, Obesity and Metabolism, Volume 28, Issue 3, Page 1984-1996, March 2026.
Abstract Aim Type 2 diabetes (T2D) is associated with increased dementia risk, but comparative data across newer glucose‐lowering therapies remain limited. We examined whether the initiation of GLP‐1 receptor agonists (GLP‐1 RAs) was associated with incident dementia compared with DPP4 inhibitors (DPP4is) and SGLT2 inhibitors (SGLT2is) in older adults ...
Ting Zhou, Huilin Tang, Bingyu Zhang, Dazheng Zhang, Yiwen Lu, Lu Li, Jiajie Chen, Yong Chen, David A. Asch, Yong Chen   +9 more
wiley   +1 more source

Association between inflammatory burden index and risk of heart failure: evidence from NHANES 2003–2017

BMC Cardiovascular Disorders
Background Systemic inflammation contributes to the progression of heart failure (HF). This study aims to investigate the association between inflammatory burden index (IBI) and HF risk.
Li-Xin Yun, Wan-Zhong Huang, Changjing He, Yuan Huang, Hua-Feng Yang, Qiang Su, Da-Zhi Lan, Yang-Chun Liu   +7 more
doaj   +1 more source

Disentangling Respiratory Phase‐Dependent and Phase‐Independent Components of Anticipatory Cardiac Deceleration

Psychophysiology, Volume 63, Issue 3, March 2026.
ABSTRACT The heart does not beat like a metronome: varying parasympathetic input to the heart leads to constant heart rate variability. Vagal cardiomotor neuron activity is coupled to the respiratory cycle, leading to respiratory sinus arrhythmia (RSA), a permanent oscillation of heart rate synchronized to respiration.
Ege Kingir, Sukanya Chakraborty, Caspar M. Schwiedrzik, Melanie Wilke   +3 more
wiley   +1 more source

How Temporal Predictability of Threat and Action Preparation Affect Defensive Freezing Responses

Psychophysiology, Volume 63, Issue 3, March 2026.
ABSTRACT Defensive responses to threat are critical for survival and often involve freezing‐like behavior, which has been linked to action preparation. However, it remains unclear how this preparatory mechanism is influenced by unpredictable aversive stimuli that are difficult to discriminate or anticipate.
Alina Koppold, Mana R. Ehlers, Alexandros Kastrinogiannis, Felix H. Klaassen, Karin Roelofs, Tina B. Lonsdorf   +5 more
wiley   +1 more source