siRNAs targeting icaD Gene of Staphylococcus aureus to Inhibit Biofilm Formation: Structural Analysis and Efficacy [PDF]
Biology, Medicine, & Natural Product ChemistryAntibiotic resistance in Staphylococcus aureus infections, especially those involving biofilm formation, is a global health issue. Biofilm protects bacteria from the immune system and antibiotic treatment, making them 10 to 1000 times more resistant. The
Dinda Ananda Sulistina +4 more
semanticscholar +3 more sources
Detection of icaA and icaD genes of Staphylococcus aureus isolated in cases of bovine mastitis in the Republic of Serbia [PDF]
Acta Veterinaria, 2017 Staphylococcus aureus (S. aureus) is the most common agent of contagious mastitis that causes serious health and economic problems. The ability to form biofilms is an important virulence factor of S. aureus for the establishment of persistent infections.
B. Suvajdžić +6 more
semanticscholar +10 more sources
Detection of Biofilm Genes (IcaA and IcaD) in Staphylococcus spp. [PDF]
Rafidain Journal of Science, 2018 One hundred thirty one clinical bacterial samples were collected from skin, pus, urine and blood from patients at Al-Salam General Teaching Hospital in Mosul city during March until July/ 2012, The present study included identification using API ID 32 ...
A. Sulaiman, Basima A. Abdulla
semanticscholar +2 more sources
Genetic Diversity and Epidemiological Overlap of Staphylococcus aureus at the Animal–Food–Environment–Human Interface Within a One Health Framework [PDF]
MicrobiologyOpen, Volume 15, Issue 5, October 2026.Integrating farm‐to‐fork and clinical surveillance, this study reveals distinct SCCmec distributions alongside shared spa types across human, animal, and food interfaces. The results of genetic diversity and epidemiological overlap underscore the critical need for coordinated One Health surveillance to monitor multi‐sectoral Staphylococcus aureus ...
Pinar Sagiroglu +12 more
wiley +2 more sources
Targeting biofilm-related genes in a clinical methicillin-resistant Staphylococcus aureus isolate using CRISPR-Cas9 gene editing [PDF]
Front MicrobiolBackground Methicillin-Resistant Staphylococcus aureus (MRSA) is a major clinical challenge due to its biofilm-forming ability. Innovative therapeutic strategies are essential to prevent bacterial attachment and disrupt biofilm structures.
Ayşegül Ateş +2 more
semanticscholar +2 more sources
Environmental and chemical modulation of Staphylococcus aureus Newman biofilm formation [PDF]
Appl Microbiol BiotechnolStaphylococcus aureus biofilm formation enhances survival on host tissues and medical devices. This study tested how oxidative stress (H₂O₂), pH (5–9), NaCl (0–10%), and human serum (5–50%) affect the Newman strain biofilm and key genes (icaA, icaD, sarA)
A. Ragab +2 more
semanticscholar +2 more sources
Evaluation of the antivirulence and anticancer potential of green-synthesized silver/zinc oxide nanocomposites against methicillin-resistant Staphylococcus aureus and melanoma cells [PDF]
Discov NanoThe escalating incidence of methicillin-resistant Staphylococcus aureus (MRSA) necessitates novel therapeutic strategies targeting antibiotic resistance and biofilm formation.
Bikhal Fattah, H. Hamzah, H. Arif
semanticscholar +2 more sources
Evaluation of icaA and icaD genes involved in biofilm formation in Staphylococcus aureus isolates from clinical sources using Reverse Transcriptase PCR [PDF]
Archives of Razi InstituteStaphylococcus aureus is known for its ability to create biofilm, which helps bacteria attach to various surfaces and poses a challenge for treatment. Biofilm formation relies on the icaABCD operon, with the icaA and icaD genes having the key role in this complex process.
M, Armoon +4 more
openaire +3 more sources
The Effects of Low Concentrations of Nisin on Biofilm Formation by Staphylococcus aureus Isolated from Dairy Cattle [PDF]
PathogensStaphylococcus aureus is one of the aetiological agents of mastitis in dairy cattle. Their biofilms are relevant for human and veterinary medicine. It has been shown that some antibiotics at low concentrations can stimulate the production of biofilms ...
Edyta Kaczorek-Łukowska +4 more
semanticscholar +2 more sources
Evaluation of biofilm production and prevalence of the icaD gene in methicillin-resistant and methicillin-susceptible Staphylococcus aureus strains isolated from patients with nosocomial infections and carriers. [PDF]
FEMS Immunology & Medical Microbiology, 2007 Staphylococcus aureus is one of the most important etiological agents responsible for healthcare-associated infections and is capable of producing many virulence factors including biofilm. The aim of the present study was to analyze the correlation between the presence of the icaD and icaA genes and the ability to produce biofilm in vitro in 302 ...
M. Grinholc, G. Węgrzyn, J. Kurlenda
semanticscholar +4 more sources