Results 131 to 140 of about 317,186 (262)

Asymmetric Structure‐Driven Functional Synergy: A Multistimuli‐Activated Janus Nanomotor for Self‐Amplifying NO Cascade Therapy

Advanced Science, EarlyView.
The Janus nanomotors leverage an “asymmetric structure‐driven functional synergy” strategy to orchestrate spatiotemporally coordinated catalytic functions, in situ self‐amplifying NO generation, and deep tumor penetration, thereby enabling controllable, sustained, and uniform NO generation within the tumor microenvironment.
Chengcheng Li, Yu Zhang, Yu Chen, Lingyun He, Xian Shen, Weijian Sun, Hongbo Zhang   +6 more
wiley   +1 more source

Athletes with Implantable Cardioverter-Defibrillators: A Practical Framework for Device Selection, Programming, and Return-to-Sport Risk Mitigation. [PDF]

J Clin Med
Sharp Dimitri D, Prutkin JM.
europepmc   +1 more source

Temporal‐Targeted Accelerated 40 Hz tACS Enhances Cognitive Function and Network Integration in Alzheimer's Disease: A Randomized Clinical Trial

Advanced Science, EarlyView.
Bilateral temporal accelerated 40‐Hz tACS improves cognitive function in patients with Alzheimer's disease. Resting‐state fNIRS identifies treatment‐related increases in frontotemporoparietal functional connectivity, which are associated with cognitive improvement. ABSTRACT The temporal lobes are key hubs for memory and cognition.
Rong Guo, Xingxing Li, Chenjun Zou, Chao Zheng, Xiaohong Wu, Xuechao Lu, Jiaying Yan, Junfang Zhang, Xiaoyan Luo, Shiwei Ye, Dongsheng Zhou   +10 more
wiley   +1 more source

Sensitize Tumor Immunotherapy: Immunogenic Cell Death Inducing Nanosystems

International Journal of Nanomedicine
Jianlan Peng,1 Shiying Li,2 Huihui Ti1,3 1School of Chinese Materia Medica, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China; 2Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State ...
Peng J, Li S, Ti H
doaj  

The Relationship Between Immunogenic Cell Death and Cellular Senescence in Cancer Immunotherapy. [PDF]

Life (Basel)
Shin SA, Kim M, Kim M, Choi S, Park HH, Lee CS.   +5 more
europepmc   +1 more source

Glutaminolysis Blockade‐Empowered Bimodal Nanodepot for Spatially Complementary Sono‐Thermal Ablation via PANoptosis and STING Activation Against Large Tumors

Advanced Science, EarlyView.
An injectable bimodal TCPD nanodepot disrupts glutaminolysis and TCA metabolism, sensitizing large tumors to spatially complementary sono‐thermal ablation for complete treatment coverage. This intervention induces mitochondrial and endoplasmic reticulum dysfunction, genotoxicity, and NAD+ depletion, converging to trigger PANoptosome assembly and ...
Yi‐Ming Liu, Juan Qin, Si‐Yuan Wu, Xue‐Zhen Zhu, Yun‐Fei Cai, Pei‐Yao Sun, Hao Yang, Xing‐Yue Wang, Shu Li, Duo Wang, Hai‐Dong Zhu   +10 more
wiley   +1 more source

Incidence of Graves’ Disease with Validation and Completeness of the Diagnosis for Registry Extracts in the Danish National Patient Register

Clinical Epidemiology
Frederik Østergaard Klit,1,2 Jakob Dal,1– 3 Stine Linding Andersen,1,4 Amar Nikontovic,3 Peter Vestergaard,2,3 Jesper Scott Karmisholt1,2 1Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; 2Department of Endocrinology, Aalborg ...
Klit FØ, Dal J, Andersen SL, Nikontovic A, Vestergaard P, Karmisholt JS   +5 more
doaj  

A case for the introduction of the ICD-11 in Germany. [PDF]

Ger Med Sci
Stausberg J, Bartkowski R, Gaebel W, Treede RD.   +3 more
europepmc   +1 more source

In Situ Bioorthogonal Synthesis of PROTACs via Dual‐Responsive Cleavage for Synergistic Photo‐Immunotherapy

Advanced Science, EarlyView.
A bioactive self‐delivering SNAP‐TAC platform responds to tumor‐associated cathepsin B and glutathione, enabling in situ bioorthogonal synthesis of a BRD4‐degrading proteolysis‐targeting chimera within the tumor microenvironment. The resulting BRD4 degradation and PD‐L1 downregulation synergize with photodynamic therapy‐induced immunogenic cell death ...
Shiqin Jian, Jiasha Wu, Fusheng Xu, Yan Zuo, Huaxing Shen, Rui Ji, Luyi Wang, Na Li, Yanting Sun, Yongsheng Yu, Yejiao Shi, Honggang Hu, Feng Xu, Dan Huang, Xiaochun Hu   +14 more
wiley   +1 more source

Magnetocardiographic Rotation Score and Arrhythmic Endpoints in Primary-Prevention ICD Recipients: An Exploratory Substudy of the Magneto-SCD Trial. [PDF]

J Clin Med
Lachlan T, He H, Miller A, Chandan N, Hwang T, Siddiqui S, Beadle R, Wilson D, Petkar S, Lim VG, Kimani PK, Osman F.   +11 more
europepmc   +1 more source