Results 111 to 120 of about 547,458 (298)

Targeting Peptostreptococcus anaerobius with an Iron‐Based Nanozyme Reverses Ferroptosis Resistance and Enhances Antitumor Immunity in Colorectal Cancer

Advanced Science, EarlyView.
An iron‐based nanozyme selectively eliminates intratumoral P. anaerobius while catalytically generating ROS to induce ferroptosis, synergistically suppressing colorectal cancer growth and activating anti‐tumor immunity through immunogenic cell death. ABSTRACT The intratumoral microbiota is a critical determinant of therapeutic outcomes in colorectal ...
Yinghao Cao, Jun Wang, Hanwenchen Wang, Xiang Sun, Fang Fang, Shiying Li, Jianping Liu, Changrong Shi, Pengyuan Qi, Jianhua Zou, Xiaoyuan Chen, Kailin Cai   +11 more
wiley   +1 more source

Comparison of Diagnosis Codes to Clinical Notes in Classifying Patients with Diabetic Retinopathy

Ophthalmology Science
Purpose: Electronic health records (EHRs) contain a vast amount of clinical data. Improved automated classification approaches have the potential to accurately and efficiently identify patient cohorts for research.
Sean Yonamine, MPH, Chu Jian Ma, MD, PhD, Rolake O. Alabi, MD, PhD, Georgia Kaidonis, MBBS, PhD, Lawrence Chan, MD, Durga Borkar, MD, Joshua D. Stein, MD, MS, Benjamin F. Arnold, PhD, Catherine Q. Sun, MD   +8 more
doaj   +1 more source

PERANCANGAN APLIKASI ELECTRONIC MEDICAL RECORD (EMR) PADA INSTALASI RAWAT INAP BERBASIS WEB [PDF]

, 2011
Pelayanan medik dewasa ini membutuhkan sistem yang lebih efektif dan efisien, baik dalam penggunaan waktu, tenaga maupun sarana. Dalam pengelolaan rekam medik, kenyataan masih umumnya penggunaan rekam medik manual yang dinilai tak lagi andal menangani ...
Handoyo, Eko, Muttaqin, Moh, Sofwan, Aghus   +2 more
core  

Highly Active Cu14 Cluster Precisely Activates Autophagy Inhibitor to Amplify Cuproptosis Immunotherapy

Advanced Science, EarlyView.
An atomically precise Cu14 cluster‐mediated bond scission reaction pioneers the amplification of the antitumor immune response via synergetic cuproptosis‐associated immunogenic cell death induction and in situ autophagy blockade. ABSTRACT Transition metal‐mediated cleavage mechanisms have emerged as an effective means to mitigate the off‐target ...
Qiu‐Xu Zang, Wei‐Tong Chen, Yu‐Ying Shen, Zhao‐Yang Wang, Kai Li, Xueli Zhao, Yanjuan Sang, Xiaoyuan Chen, Shuang‐Quan Zang   +8 more
wiley   +1 more source

Phenomenological Psychopathology and Psychiatric Classification [PDF]

, 2019
In this chapter, I provide an overview of phenomenological approaches to psychiatric classification. My aim is to encourage and facilitate philosophical debate over the best ways to classify psychiatric disorders.
Fernandez, Anthony Vincent
core  

Endothelial GPR68 Is Essential for Arteriogenesis and Represents a Therapeutic Target in a Model of Peripheral Artery Disease

Advanced Science, EarlyView.
Endothelial GPR68 is identified as a critical regulator of collateral artery growth in peripheral artery disease. Genetic and pharmacological evidence demonstrates that GPR68 integrates hemodynamic cues to drive monocyte recruitment and inflammatory remodeling, thereby promoting collateral arteriogenesis and tissue perfusion after ischemia ...
Yiyan Song, Senyi Peng, Zhilei Huang, Miao Yu, Mingyue Wu, Yuexin Zhu, Zeyi Zhou, Yongshan Liu, Yalin Zhang, Yu Huang, Zhongxing Wang, Fu‐Li Xiang, Jie Xu   +12 more
wiley   +1 more source

Evaluation of Emergency Department Admissions in Syrian Patients Aged Under Eighteen Years of Age Between 2012 and 2016 in the City of Hatay

Journal of Pediatric Emergency and Intensive Care Medicine, 2019
Introduction:Wars are disasters leading to irreversible consequences that affect great numbers of people. Injuries and deaths are considered to be direct effects of wars and these effects are felt more in places near war zones.
Ezgi Atalay, Ali Karakuş, Galip Usta
doaj   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Are ICD-10 categories suitable for diagnosing injuries? Multidisciplinary analyses of the English, German, and Hungarian ICD-10 diagnosis categories

Scripta Manent, 2019
ICD-10 is a standardized diagnostic tool of the World Health Organization (WHO) for the documentation of findings to facilitate statistical comparability. It enhances fast diagnosis documentation using a globally readable coding.
Katalin Fogarasi, Alexandra Csongor, Philipp Schneider   +2 more
doaj  

Liquid Metal Nanotransformers for Drug‐Resistant Pan‐Cancer Therapy in Patient‐Derived Organoids

Advanced Science, EarlyView.
Pan‐cancer therapies are severely limited in drug‐resistance patients due to genetic mutations and other factors, resulting in poor therapeutic outcomes and constrained clinical benefit. Liquid metal nanotransformers, a new class of shape‐transformable nanomaterials capable of dramatic morphological changes, offer a promising physical strategy to ...
Xiaojie Yuan, Xuelin Wang, Zhongyao Chen, Shuo Wang, Weining Gao, Ziyi Chen, Runyang Li, Cheng Hao, Lei Zhang, Qiongqiong Zhang, Ke Zhang, Mei Yu, Qian Liu, Jingxuan Wang, Huiping Li, Simpkins Fiona, Jing Liu, Qiang Liu, Peng Liu, Yawei Hu   +19 more
wiley   +1 more source