Results 241 to 250 of about 45,044 (305)

De Novo Design and Directed Evolution Refinement of Mirror‐Image Protein Binders Targeting Interleukin‐4

Advanced Science, EarlyView.
This study presents the de novo design and directed evolution of a mirror‐image D‐protein inhibitor targeting human interleukin‐4 (IL‐4). The engineered molecule exhibits nanomolar binding affinity for IL‐4 and effectively inhibits IL‐4–mediated signaling.
Liqing Xu, Yuxiang Ren, Tongyue Wang, Hongyong Li, Yue Yao, Lei Liu, Ke Sun, Peilong Lu   +7 more
wiley   +1 more source

Tunable icephobicity of surface-grown metal-organic frameworks with nanohierarchical texture.

Nanoscale
Bahal S, Zhang J, Singh V, Kabi P, Heydari A, Tiwari MK.   +5 more
europepmc   +1 more source

Efficient Corona Suppression Coatings and Their Behavior in Corrosive and Icy Environments. [PDF]

Materials (Basel)
Emelyanenko KA, Teplonogova MA, Emelyanenko AM, Boinovich LB.   +3 more
europepmc   +1 more source

Functional Analysis of Ligand‐Gated Chloride Channels in a Cnidarian Sheds Light on the Evolution of Inhibitory Signaling

Advanced Science, EarlyView.
We uncover a large variety of putative inhibitory ligand‐gated ion channels (LGICs) in the phylum Cnidaria, the sister group to all bilaterian animals. Phylogenetic analysis suggests a complex evolutionary history of inhibitory LGICs with diverse neurotransmitter ligands.
Abhilasha Ojha, Linda Kloss, Juan D. Montenegro, Simone Albani, Audrey Ortega‐Ramírez, Mihaela Raycheva, Sylvia Joussen, Sabrina Kaul, Michèle Bachmann, Lisa Huf, Günther Schmalzing, Alison G. Cole, Ulrich Technau, Stefan Gründer   +13 more
wiley   +1 more source

Differentiated planetesimals record differing sources of sulfur in inner and outer solar system materials. [PDF]

Proc Natl Acad Sci U S A
Heiny EA, Stolper EM, Eiler JM.
europepmc   +1 more source

Time‐Controlled Refrigerated Stem Cell Therapy Mitigates Scleroderma Fibrosis via Modulation of Mitochondrial Autophagy and Gut Metabolism

Advanced Science, EarlyView.
This study established an RT‐MSCs‐based therapeutic approach for scleroderma in mice. RT‐MSCs attenuated fibrosis by regulating mitochondrial autophagy and restored gut microbiota homeostasis. Metabolomic analyses confirmed recovery of key metabolites, and RT‐MSCs demonstrated favorable lesion targeting and safety profiles.
Xue Xia, Chenfei Kong, Xiaoming Zhao, Naixu Shi, Jinlan Jiang, Ping Li   +5 more
wiley   +1 more source

Recent Advances in the Observation and Modeling of Aerosol-Cloud Interactions, Cloud Feedbacks, and Earth's Energy Imbalance: A Review. [PDF]

Curr Pollut Rep
Michibata T, Wall CJ, Hirota N, Duran BM, Nozawa T.   +4 more
europepmc   +1 more source

DOT1L Drives Endothelial‐to‐Mesenchymal Transition and Fibrotic Vascular Remodeling via H3K79 Methylation

Advanced Science, EarlyView.
DOT1L as a central epigenetic regulator of EndoMT and pulmonary fibrosis. Acting as an early epigenetic switch, it translates TGFβ–SMAD signaling into H3K79me2‐mediated chromatin remodeling, selectively activates fibrosis‐related genes, and primes ECs for rapid mesenchymal transition.
Yaofeng Wang, Xing Peng, Jingjing Chen, Yun Zhang, Tinghong Zhang, Jingyuan Zhang, Jiaying Fan, Hui Zheng, Qiaoyuan Liu, Zhimin Song, Zhan‐Peng Huang, Shu Meng   +11 more
wiley   +1 more source

Completed genomes from <i>Variovorax</i> provide insight into genome diversification through horizontal gene transfer. [PDF]

Curr Res Microb Sci
Ville CJN, Orwin PM.
europepmc   +1 more source

Thermodynamic mechanisms governing icing: Key insights for designing passive anti-icing surfaces. [PDF]

iScience
Xu Z, Wang G, Li S, Li D, Zhou W, Yang C, Sun H, Liu Y.   +7 more
europepmc   +1 more source