Results 121 to 130 of about 597,547 (288)

Investigation of North Pacific sea ice anomalies in the context of atmospheric and oceanic variability [PDF]

, 2001
Thesis (M.S.) University of Alaska Fairbanks, 2001This study investigates the main mode of variability in North Pacific sea ice and examines the relationship between sea ice concentration and northern hemispheric climate variability for the period 1968 ...
Tivy, Adrienne
core  

Sea ice trends in climate models only accurate in runs with biased global warming

, 2017
Observations indicate that the Arctic sea ice cover is rapidly retreating while the Antarctic sea ice cover is steadily expanding. State-of-the-art climate models, by contrast, typically simulate a moderate decrease in both the Arctic and Antarctic sea ...
Eisenman, Ian, Rosenblum, Erica
core   +1 more source

4‐Hydroxybenzyl Alcohol Mitigates Hyperlipidemia‐Associated Depression by Inhibiting Neuroinflammation via the NKIRAS2/NF‐κB Pathway

Advanced Science, EarlyView.
4‐HBA upregulates NKIRAS2 levels, inhibiting the activation of the NF‐κB pathway and subsequently reducing the levels of neuroinflammatory markers. This modulation helps restore normal mood and behavior in hyperlipidemic conditions, providing a potential therapeutic strategy for managing hyperlipidemia‐associated depression.
Ying Zhang, Meng Teng, Wenxuan He, Lanzhou Li, Yongfeng Zhang, Shimiao Wang, Chunyue Wang, Di Wang   +7 more
wiley   +1 more source

Adipocyte‐Derived Exosomal miR‐5099 Mitigates M1 Macrophage Polarization and Adipose Inflammation via c‐Met/NF‐κB Axis to Improve Metabolic Health

Advanced Science, EarlyView.
Celastrol upregulates adipocyte‐derived exosomal miR‐5099, suppressing the macrophage c‐Met/NF‐κB axis to mitigate pro‐inflammatory M1 polarization and adipose inflammation. These miR‐5099‐enriched exosomes also act as endocrine signals targeting the liver, muscle, and adipocytes to significantly enhance systemic insulin sensitivity.
Ping Tang, Lixin Tai, Hongxia Xu, Dongliang Zhu, Jiajia Li, Hao Feng, Jinghui Cui, Shuhai Lin, Li‐jun Di, Li Wang   +9 more
wiley   +1 more source

Ice sheet humming and climate change

, 2023
The Antarctic and Greenland ice sheets will play a major role for global sea level rise in the decades and centuries to come. Antarctic climate and mass balance have been highlighted by the Intergovernmental Panel on Climate Change (IPCC) as key sources of uncertainty when predicting the future climate system and sea level, and that significant ...
Eisen, Olaf, Zigone, Dimitri, Pearce, Emma, Fichtner, Andreas, Hofstede, Coen   +4 more
openaire   +1 more source

Ice cores and SeaRISE: What we do (and don't) know [PDF]

Ice core analyses are needed in SeaRISE to learn what the West Antarctic ice sheet and other marine ice sheets were like in the past, what climate changes led to their present states, and how they behave.
Alley, Richard B.
core   +1 more source

Climate-Vegetation-Feedbacks as a Mechanism for Accelerated Climate Change: The onset of the African Humid Period [PDF]

, 2008
Paleo-environmental records and models indicate that the African Humid Period (AHPabruptly ended about 5000-4000 years before present (BP). Some proxies indicate alsan abrupt onset of the AHP between 14,000 and 11,000 BP.
Köhler, Peter, Menviel, L., Timm, O., Timmermann, A.   +3 more
core  

Bioenergy Cropping Reduces the Spatiotemporal Scaling of Soil Bacterial Biodiversity

Advanced Science, EarlyView.
Consistent with patterns observed in plant and animal communities, soil bacterial communities exhibit significant species–time–area and phylogenetic–time–area relationships independent of nested structure. Bioenergy cropping significantly reduces the spatiotemporal scaling rates, particularly in sandy loam soils.
Zhencheng Ye, Jialiang Kuang, Colin T. Bates, Arthur Escalas, Daliang Ning, Liyou Wu, Suo Liu, Sihang Deng, Jiesi Lei, Xiangwen Chen, Jennifer Pett‐Ridge, Malay Saha, Lauren Hale, Gangsheng Wang, Renmao Tian, Ying Fu, Yu Tang, Mary Firestone, Jizhong Zhou, Yunfeng Yang   +19 more
wiley   +1 more source

NIBAN2/FLII/RREB1 Axis Drives Glioma Stem Cell Malignancy via TLR3 Pathway Activation

Advanced Science, EarlyView.
NIBAN2, highly expressed in glioma stem‐like cells (GSCs), assembles with FLII and transcription factor RREB1 to form a nuclear complex. This complex transcriptionally activates stemness‐associated genes (e.g., CD44, NANOG) and metabolic enzymes (e.g., LDHA), thereby sustaining both transcriptional and metabolic stemness programs.
Liang liang Shi, Xinwei Qiao, Yue Hu, Minjie Wang, Shaojie Yu, Zihan Gong, Yuxin Rao, Hui Zheng, Siting Chen, Lin Li, Rong Fu, Tao Liang, Jin Yao, Xiaobing Jiang, Junjun Li   +14 more
wiley   +1 more source

RIPK3 Orchestrates Scar‐Associated Macrophage Dysfunction to Drive Pulmonary Fibrosis

Advanced Science, EarlyView.
Beyond signaling cell death, RIPK3 emerges as a critical metabolic regulator in pulmonary fibrosis. This research reveals that RIPK3 promotes PI3K‐AKT signaling in scar‐associated macrophages to fuel polyamine synthesis, independent of its kinase activity.
Tao Yang, Xiao Li, Shuyue Lei, Qingqing Li, Yi Zhang, Zhizhen Hui, Jinjin Ren, Xuelian Yang, Xiaoqian Yang, Chunlan Feng, Yousheng Xu, Dongxin Zhao, Wei Tang   +12 more
wiley   +1 more source