Results 181 to 190 of about 2,872,579 (294)

Dual Role of Tamoxifen in Enhancing STING and CEACAM1 Expression to Prime a Favorable Tumor Microenvironment for Anti‐TIM3 Immunotherapy

Advanced Science, EarlyView.
Anti‐PD‐1/PD‐L1 blockade has revolutionized cancer immunotherapy, but is ineffective against endocrine‐treated (i.e., Tamoxifen), relapsed ER+ breast cancer (BC) patients. This study provides insight into the sub‐optimal response of ER+BCs to anti‐PD‐1/PD‐L1 blockade – highlighting the induction of STING and the CEACAM1/TIM3 axis after chronic ...
Marvin Angelo E Aberin, Saurabh Singh, Soumya Chatterjee, Guang‐Zhi Sui, Yi‐Fu Wang, Ya‐Ting Lu, Yu‐Ling Lee, Kun‐Yuan Lin, Joy Khag, Ta‐Yu Liu, Shao‐Han Chang, Wai‐Mui Cheung, Hsiao‐Chin Hong, Ren‐Jun Hsu, Chen‐Yang Shen, Chia‐Wei Li, Weng‐Lang Yang, Yao‐Ming Chang, Shih‐Yu Chen, Chandan Guha, Shu‐Ping Wang   +20 more
wiley   +1 more source

Segmented linear integral correlation Kernel ensemble reconstruction: A new method for climate reconstructions with applications to Holocene era proxies from an East Antarctic ice core. [PDF]

PLoS One
Roberts JL, Jong LM, McCormack FS, Kiem AS, Curran MAJ, Moy AD, Macha JMA, Plummer CT, French WJR, Ommen TDV.   +9 more
europepmc   +1 more source

Phosphorylation‐Facilitated CKB Lactylation At K11 By GCN5 Enhances Creatine Kinase Activity and Mitigates Neuronal Damage After Cerebral Ischemia‐Reperfusion

Advanced Science, EarlyView.
This study uncovers hierarchical coordination between K11 lactylation and S199 phosphorylation of CKB in cerebral ischemia‐reperfusion injury. Such dual modifications potentiate CKB enzymatic function, remodel energy metabolism, alleviate oxidative stress and neuronal damage, and represent a viable therapeutic target for stroke treatment.
Chao Duan, Ruolin Zhang, Shihui Ding, Ying Feng, Tao Shen, Ziwei Wang, Wendai Bao, Ke Shui, Jun Qin, Jun Chen, Min Zhang, Zijing Ren, Dongmei Zhao, Xingrong Guo, Zhibing Ai, Xin Yang, Peiyang Zhou, Zhiqiang Dong   +17 more
wiley   +1 more source

An East Antarctic, sub-annual resolution water isotope record from the Mount Brown South Ice core. [PDF]

Sci Data
Gkinis V, Jackson S, Abram NJ, Plummer C, Blunier T, Harlan M, Kjær HA, Moy AD, Peensoo KM, Quistgaard T, Svensson A, Vance TR.   +11 more
europepmc   +1 more source

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

Advanced Science, EarlyView.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen   +16 more
wiley   +1 more source

Improved biomass burning emissions from 1750 to 2010 using ice core records and inverse modeling. [PDF]

Nat Commun
Zhang B, Chellman NJ, Kaplan JO, Mickley LJ, Ito T, Wang X, Wensman SM, McCrimmon D, Steffensen JP, McConnell JR, Liu P.   +10 more
europepmc   +1 more source

Organic Compounds in a Sub-Antarctic Ice Core: A Potential Suite of Sea Ice Markers. [PDF]

Geophys Res Lett, 2019
King ACF, Thomas ER, Pedro JB, Markle B, Potocki M, Jackson SL, Wolff E, Kalberer M.   +7 more
europepmc   +1 more source

Chemoproteomic Identification of AKT2 as a Paclitaxel‐Binding Protein via C─C Bond‐Linked Probe PTX‐4 in Paclitaxel‐Resistant Breast Cancer

Advanced Science, EarlyView.
ABSTRACT Breast cancer remains one of the most prevalent malignancies among women, and taxane‐based chemotherapies such as paclitaxel and docetaxel are central to standard treatment regimens. However, drug resistance in breast cancer limits therapeutic efficacy and contributes to recurrence and metastasis.
Kai Wang, Yuqing Yuan, Wei Shen, Xiuxiu Yang, Xiaokang Wu, Haihua Zhou, Yi Hu, Qing Zhu   +7 more
wiley   +1 more source

Reconciling ice core CO₂ and land-use change following New World-Old World contact. [PDF]

Nat Commun
King ACF, Bauska TK, Brook EJ, Kalk M, Nehrbass-Ahles C, Wolff EW, Strawson I, Rhodes RH, Osman MB.   +8 more
europepmc   +1 more source

Ice coring and drilling technologies developed by the Polar Ice Coring Office

Ice coring and drilling technologies developed by the Polar Ice Coring Office
P(論文) The search for "zero defects" ice cores continues to challenge the ice coring and drilling community. No single drilling and coring device will fill all needs. Each project will have special requirements and will require an initial decision as to the most effective drilling system to be used as well as ensuring personal and environmental safety ...
openaire   +1 more source