Results 241 to 250 of about 1,022,984 (305)

Ovarian Matrisome Dynamics and αvβ3‐Mediated Regulation in Early Follicular Development

Advanced Science, EarlyView.
The matrisome undergoes dynamic remodeling during early follicular development. Integrin αvβ3 mediates matrisome signals, regulating primordial follicle activation/atresia and secondary follicle growth via Hippo/mTOR pathways, with conserved roles in human ovaries, offering therapeutic targets for ovarian disorders.
Tong Wu, Yanzhi Feng, Qingqing Zhu, Ting Jiang, Yueyue Gao, Kebing Nie, Xianan Tang, Ying Chen, Dianxing Hu, Xudan Yang, Shixuan Wang, Meng Wu, Jinjin Zhang   +12 more
wiley   +1 more source

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

Advanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun, Haochen Yang, Qing Xu, Xingya Li, Jinxing Lou, Jianchun Duan, Jiachen Xu, Zhuqing Liu, Yong Xia, Zhicai Lin, Linlin Li, Dan Sun, Jiaguo Li, Tao Liu, Jun Guo, Wenfeng Xu, Weimin Zhu, Yi Liu, Boyang Sun, Jia Zhong, Lijie Rong, Qijun Qian, Chenqi Xu, Jie Wang   +23 more
wiley   +1 more source

Multi-phase retreat of the Laurentide Ice Sheet and associated freshwater release from Hudson Bay during the last deglaciation. [PDF]

Sci Rep
Duboc Q, Brouard E, St-Onge G, Lajeunesse P, Moros M, Perner K, Roy M.   +6 more
europepmc   +1 more source

Geochemical characterization of millions of individual atmospheric particles entrapped in Antarctic ice across the last glacial-interglacial transition. [PDF]

Sci Rep
Kutuzov S, Olesik JW, Lomax-Vogt MC, Carter LM, Lowry GV, Bland GD, Wielinski J, Sullivan RC, Gabrielli P.   +8 more
europepmc   +1 more source

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ICE CORES

2014
Ice cores from Antarctica, from Greenland, and from a number of smaller glaciers around the world yield a wealth of information on past climates and environments. Ice cores offer unique records on past temperatures, atmospheric composition (including greenhouse gases), volcanism, solar activity, dustiness, and biomass burning, among others.
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Ice core data

2012
Oard (2005) provides an excellent introductory overview of ice cores from the ice sheets at Greenland and Antarctica. The two great ice sheets presently existent on Earth are located where landmasses exist near the poles: Greenland and Antarctica. Both ice sheets store a huge amount of water, as indicated in Table 4.1.
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Ice core methodology

2012
Willi Dansgaard is a Danish scientist who is credited with the original idea of using ice cores to probe temperature changes over the past thousands of years. His book provides a very interesting history of the early evolution of this technique (Dansgaard, 2005).
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ICE Core Concepts

ICE Core Concepts: Geotechnical Engineering is an engaging, practical introduction to the analysis, design, construction, maintenance and renovation of geotechnical structures. Each chapter presents concise coverage of a core subject area in geotechnical engineering.
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Ice Core

2021
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