Results 41 to 50 of about 198,361 (267)
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source
Air reverse circulation at the hole bottom in ice-core drilling
Journal of Glaciology, 2019 Ice-core drilling to depths of 200–300 m is an important part of research studies concerned with paleoclimate reconstruction and anthropogenic climate change. However, conventional drilling methods face difficulties due to firn permeability.
ZHENGYI HU +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler +3 more
wiley +1 more source
Strengthening ice through cyclic loading
Journal of Glaciology, 2017 New experiments reveal that the flexural strength of fresh water, columnar-grained ice loaded normal to the columns may be increased by about a factor of two upon reversed cyclic loading at a frequency of ~0.1 Hz at stress amplitudes of 1.3–2.6 MPa.
DANIEL ILIESCU +3 more
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
IEEE AccessThe development of nanofunctionalized transformer oils has sparked growing interest in understanding their electrical discharge behavior. This review presents a comprehensive analysis of diagnostic methods used to investigate partial discharges and ...
Kristian Glajc +2 more
doaj +1 more source
The effects of Ca++ on the strength of polycrystalline ice
Journal of Glaciology, 2016 Recent studies have suggested a physical link between Ca++ ions and an increase in the ductility or ‘softening’ of polycrystalline ice. In order to investigate the potential effects of Ca++ on deformation, we created sets of both undoped and CaSO4-doped ...
KEVIN HAMMONDS, IAN BAKER
doaj +1 more source
SMART MOVES JOURNAL IJOSCIENCE, 2021 Calculating the heat transfer rate of the engine is very difficult due to the complex geometry design of the engine and the periodic flow of air and fuel during engine operation for full cycles. Various theories hypothesize that about 25% of the energy contained in the fuel is converted into useful work and the remaining 75% is released into the ...
Sourabh Kumar, Mr. Rajesh Soni
openaire +2 more sources
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source