Results 81 to 90 of about 662,691 (262)

Engineered Microvascular Model of the Blood–Brain–Tumor Barrier Reveals Endothelial Remodeling in Diffuse Midline Glioma

open access: yesAdvanced Healthcare Materials, EarlyView.
We developed a patient‐derived, functional microfluidic model of the diffuse midline glioma (DMG) blood–brain–tumor barrier (BBTB) comprised of endothelial cells, astrocytes, pericytes, and tumor cells. The system forms perfusable microvasculature, reveals the BBTB retains vascular integrity, identifies DMG‐specific transcriptomic changes distinct from
Kimberly R. Bennett   +7 more
wiley   +1 more source

Targeting CD300a Signaling With a Phosphatidylserine‐Presenting Hydrogel Rescues Macrophage Dysfunction and Accelerates Diabetic Wound Healing

open access: yesAdvanced Healthcare Materials, EarlyView.
Schematic illustration of the proposed mechanism: PEG/RGD‐PSLs mimic apoptotic cells to engage PS receptors (notably CD300a), transducing an inhibitory signal that suppresses the MyD88/NF‐κB pathway, leading to global anti‐inflammatory and pro‐reparative effects.
Lele Wu   +10 more
wiley   +1 more source

ice-hunters

open access: yes, 1981
ice nRe-file. FEB 1981We have plentyUsed I and SupUsed I2Not used~ bird/candle/-chock/clamper/master/pan/pilot/pole/saw/blind(ness)/-block/-boat/-skiff/-cat/-claw/clumper/-fishing/-gall/gaze/-glim/-loom/-grip/-hunter/-hunting/-island/-jam/-line ...

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Engineered Nanoplatforms Targeting Activated Hepatic Stellate Cells for Liver Fibrosis Therapy via TGF‐β Axis Inhibition and Ferroptosis Induction

open access: yesAdvanced Healthcare Materials, EarlyView.
FeS‐VA@lanifibranor (FVL), an activated hepatic stellate cell (aHSC)‐targeted nanoplatform comprising vitamin A‐functionalized two‐dimensional iron sulfide nanosheets and lanifibranor, is engineered for precision therapy of liver fibrosis. FVL suppresses the TGF‐β signaling pathway by inhibiting SMAD2/3 phosphorylation and induces ferroptosis in aHSCs,
Yinuo Yang   +11 more
wiley   +1 more source

ice-rind

open access: yes, 1971
ice nThe Newfoundlander has developed a wide vocabulary to describe ice conditions. To him, slush, ice-rind, pancake, sludge, slob, brash, and young ice each has its own characteristic.

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2‐Deoxyglucose Dendrimer‐Enabled Niclosamide Delivery to FRβ‐Expressing Macrophages Alleviates Endometriosis Progression and Associated Hyperalgesia

open access: yesAdvanced Healthcare Materials, EarlyView.
A folic acid (FA)‐conjugated 2‐deoxyglucose dendrimer selectively targets FRβ+ macrophages in endometriotic lesions, enabling precise intracellular delivery of niclosamide. This nonhormonal nanomedicine enhances drug solubility, provides controlled intracellular release, suppresses lesion growth, reduces inflammation and pain, and establishes FRβ ...
Anubhav Dhull   +11 more
wiley   +1 more source

Freeze-up ice-jam flood hazard assessment and mapping

open access: yes
Although ice-jam flooding in northern rivers is generally more severe during ice-cover breakup in spring, ice jams during river freeze-up and mid-winter breakup can also impose high flood hazard in some rivers, particularly those in regions with a ...
Lindenschmidt, Karl-Erich   +2 more
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ice master

open access: yes, 1972
ice nThe watches were divided, in turn, into ice parties, each party in charge of an experienced sealer known as an ice master, who, unlike the master watch, had no authority on board ship, only on the ice.DNE-cit PRINTED ITEMG. M. Story DEC

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Zwitterionic Polymer Coating Enabled Chronic Dopamine Sensing and Electrophysiology Recording in Free‐Moving Mice

open access: yesAdvanced Healthcare Materials, EarlyView.
Application of a zwitterionic poly(sulfobetaine methacrylate) (PSB) coating to microelectrode arrays and Ag/AgCl reference electrodes effectively inhibits biofouling and structural degradation. This strategy successfully enables simultaneous, long‐term electrophysiological recording and dopamine sensing in freely behaving mice, facilitating ...
Bingchen Wu   +5 more
wiley   +1 more source

Ice jam data collection

open access: yes, 2020
m I Ice Jam Data Collection Kathleen D. White and Jon E. Zufelr March 1994 A bstract Ice jam data collection Is necessary to gain information on Ice jam events, w hich may occur rarely and are often short-lived, but can at the same time cause large ...
Cold Regions Research and Engineering Laboratory (U.S.)
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