Results 141 to 150 of about 565,318 (348)

Using a spatially realistic load model to assess impacts of Alaskan glacier ice loss on sea level [PDF]

, 2011
Emma M. Hill, J. L. Davis, M. E. Tamisiea, Rui M. Ponte, Nadya Vinogradova   +4 more
openalex   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

A Framework for Structural Analysis of Icebreakers during Ramming of First-Year Ice Ridges

Journal of Marine Science and Engineering
This paper presents a framework for structural analysis of icebreakers during ramming of first-year ice ridges. The framework links the ice-ridge load and the structural analysis based on the physical characteristics of ship–ice-ridge interactions.
Weidong Zhao, Bernt Johan Leira, Knut Vilhelm Høyland, Ekaterina Kim, Guoqing Feng, Huilong Ren   +5 more
doaj   +1 more source

Atomistic study on the anomalous temperature-dependent dynamic tensile strength of ice under shock loading

, 2021
Y. Y. Chen, Kailu Xiao, Jiayu Yue, Qiuxia Yin, Xianqian Wu, Chenguang Huang   +5 more
openalex   +2 more sources

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Research on Sea Ice and Local Ice Load Monitoring System for Polar Cargo Vessels

Journal of Marine Science and Engineering
Sea ice and the resulting loads are major safety concerns for vessels operating in ice-covered regions. This study presents a tailored sea ice and local ice load monitoring system specifically designed for polar cargo vessels.
Jinhui Jiang, Shuaikang He, Herong Jiang, Xiaodong Chen, Shunying Ji   +4 more
doaj   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Effects of ice load prediction model and thickness on the structural loads of an offshore wind turbine

Frontiers in Energy Research
Offshore wind turbines (OWTs) installed in cold regions are prone to risking ice collisions, leading to potential damage of the support structure. It is imperative to quantitatively investigate the ice loading effect on the structural loads of OWTs.
Yongqing Lai, Ben He, Jieyi Ding, Na Lyu, Yang Yang   +4 more
doaj   +1 more source