Results 41 to 50 of about 102,397 (311)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Formation and movement of ice accumulation waves under ice cover –an experimental study

Journal of Hydrology and Hydromechanics, 2019
Ice jams in rivers often arise from the movement of frazil ice as cover-load under ice cover, a process which is conceptually similar to the movement of sediment as bed-load along a river bed. The formation and movement of an ice-accumulation wave is one
Wang Jun, Wu Yifan, Sui Jueyi, Karney Bryan   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Experimental Investigation on IceBreaking Resistance and Ice Load Distribution for Comparison of Icebreaker Bows

Journal of Marine Science and Engineering
During icebreaker navigation in ice-covered waters, icebreaking resistance and dynamic ice loads acting on the bow critically determine the vessel’s icebreaking performance.
Xuhao Gang, Yukui Tian, Chaoge Yu, Ying Kou, Weihang Zhao   +4 more
doaj   +1 more source

Analysis for Coupling Characteristic and Weakness of “Source-Network-Load” Under Ice Storms [PDF]

Dianli jianshe
[Objective] Under extreme ice-disaster conditions， the power-generation capacity of wind and solar energy declines significant while the probability of power-equipment failure increases significantly， thus resulting in severe supply-demand imbalances ...
XIE Yigong, WU Chen, HUANG Qianqian, FANG Sidun
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Statistical Analysis of Ice Load on Icebreaker Ship Based on Stochastic Ice Fields

Journal of Marine Science and Engineering
Accurately assessing ice loads is a fundamental issue in the field of structural design for ships in ice-covered regions. In this paper, we conducted research on extreme ice load estimation for icebreaking ships, combining stochastic theory with ...
Liang Li, Guangchun Han, Shunying Ji
doaj   +1 more source

Steady-State Motion of a Load on an Ice Cover with Linearly Variable Thickness in a Channel [PDF]

, 2023
Konstantin Shishmarev, Т. И. Хабахпашева, Kristina Oglezneva   +2 more
openalex   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Design consideration of two candidate propellers for ice breaking vessel

Antarctic Record, 1985
The propellers for ships operating in the Antarctic and Arctic regions encounter fragments of ice and sometimes are damaged according to the severity of ice load. The design of propellers for such ships is quite different from that of conventional ships,
Takao Sasajima, Katsuyoshi Takekuma, Yoshio Kayo   +2 more
doaj   +1 more source