Results 51 to 60 of about 102,397 (311)
Physical modeling of ice load on extended hydraulic constructions. Sloping constructions with an inclined edge [PDF]
, 2021 Aleksei Dobrodeev, Kirill Sazonov
openalex +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Strengthening ice through cyclic loading [PDF]
Journal of Glaciology, 2017 ABSTRACTNew experiments reveal that the flexural strength of fresh water, columnar-grained ice loaded normal to the columns may be increased by about a factor of two upon reversed cyclic loading at a frequency of ~0.1 Hz at stress amplitudes of 1.3–2.6 MPa.
DANIEL ILIESCU +3 more
openaire +2 more sources
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece +18 more
wiley +1 more source
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
Study on Ice Parameters Affecting DP Performance of FPSO in Arctic Ocean
한국해양공학회지, 2018 Recently, various efforts have been made to develop oil and gas in the Arctic Ocean. It is very important to consider the load caused by ice in designing floating structures in the area.
Sol-Mi Choi +3 more
doaj +1 more source
MODE OF ICE LOAD ACTING ON ICE BOOM FOR ICE CONTROL
PROCEEDINGS OF CIVIL ENGINEERING IN THE OCEAN, 1999 The Okhotsk Coast of Hokkaido is covered with drift ice in winter. Drift ice that rushes into Saroma Lagoon causes heavy damage to scallops and oysters, and aquacultural facilities. So, an ice boom that prevents drift ice from rushing into the lagoon was constructed. The ice force acting on this ice boom depends on the fluid force, and it is determined
Shunsuke MAKITA +4 more
openaire +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Thermal ice loads on structures
Education and Research Archive, 1996 Structural engineering report SER 213 | SER-ID ...
Hrudey, T. M., Azarnejad, A. (Azita)
openaire +3 more sources