Results 251 to 260 of about 371,085 (299)

CD44‐Targeting Hydroxyapatite Nanoparticles (HAP) Induce Mitochondrial Dysfunction‐Driven PANoptosis and Immunogenic Cell Death (ICD) via Ca Overload in Colorectal Cancer

Advanced Science, EarlyView.
ABSTRACT Colorectal cancer (CRC) remains therapeutically challenging due to high metastasis, recurrence, and immunotherapy resistance driven by tumor microenvironment‐mediated immune evasion. Immunogenic cell death (ICD) offers a promising strategy to reshape the immune microenvironment, yet existing ICD inducers suffer from poor targeting efficiency ...
Yao Xiao, Yuxuan Yang, Haosen Qiu, Jia Yang, Hao Liang, Zhaojun Jiang, Xiao Tong, Yongying Li, Qunfeng Huang, Jiaming Wu, Tian Lin, Jiang Yu, Min Liang   +12 more
wiley   +1 more source

Artifact-free preparation of biological samples for SEM by optimized water freeze-drying. [PDF]

Sci Rep
Ishida H, Fukuda N, Shimada M, Yamamoto K, Gaponova L, Higuchi R, Kolosiuk A, Hoshina R, Arikawa M, Fukuda Y, Islam MDS, Harumoto T, Wan Y, Itoh T, Inai Y, Takeishi A, Aonuma H, Kikuchi T, Nishigori S, Maruyama T, Ikeda K, Iriko H, Suzaki T.   +22 more
europepmc   +1 more source

CK2α Deficiency Drives Myocardial Fibrosis via Desmin‐Induced Mitochondrial Dysfunction

Advanced Science, EarlyView.
CK2α preserves mitochondrial homeostasis by phosphorylating Desmin to recruit Cryab, ensuring proper filament assembly. CK2α deficiency disrupts this interaction, causing mitochondrial dysfunction, metabolic shifts, bioenergetic failure, and oxidative stress—ultimately establishing a pro‐fibrotic environment that drives cardiac fibrosis.
Canjie Ma, Jiali Jia, Juncong Lan, Jing Wang, Dan Rao, Lanlan Rao, Weibin Zhang, Dongpeng Wu, Jie Zhang, Gang Wang, Baohua Liu, Ying Ao, Zimei Wang   +12 more
wiley   +1 more source

AI for atmosphere-ocean sciences: advancements, challenges and ways forward. [PDF]

Natl Sci Rev
Luo JJ, Xia J, Pan B, Ham YG, Li X, Shangguan W, Xue W, Wang Y, Mu B, Hong Y, Li H, Zhong X, Dai K, Bai L, Ling F, Boers N, Bretherton C, Chen B, Cho D, Gentine P, Guo Z, Huang X, Kang D, Kim HJ, Kim JH, Lei L, Meng F, Oh SH, Qin B, Shen Z, Sun Q, Tang Y, Tong X, Wan B, Wang L, Wang Y, Wang Y, Wu J, Xiao Y, Yao L, Yang S, Yuan C, Yuan S, Yu T, Zhao M.   +44 more
europepmc   +1 more source

CFD Mechanistic Modeling of a Monolithic Chromatography System: Challenges and Opportunities. [PDF]

ACS Omega
Coimbra JC, Prata DM, Fernandes RN, Arêdes Martins M, Minim LA.   +4 more
europepmc   +1 more source

High-resolution climate reconstruction from historical Chinese weather records using optimized natural language processing. [PDF]

Sci Rep
Li T, Shi T.
europepmc   +1 more source

Multi-parameter time series dataset recorded during blowdown of CO₂ and mixtures from à 2m³ sphere, up to 130 bar and down to -50°C. [PDF]

Data Brief
Jamois D, Proust C, Teberikler L, Fahmi A.   +3 more
europepmc   +1 more source

A novel experimental platform to monitor solid/water interfaces under freeze-thaw cycles. [PDF]

J Microsc
Recalcati C, Yivlialin R, Duò L, Guadagnini A, Bussetti G.   +4 more
europepmc   +1 more source

Transient ice ring observed during the 15 January 2022 eruption of Hunga volcano. [PDF]

Commun Earth Environ
Prata AT, Grainger RG, Taylor IA, Lambert A.   +3 more
europepmc   +1 more source