Results 41 to 50 of about 22,532,109 (241)
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
National and European Critical Infrastructure
Applied Medical Informatics, 2021 What exactly is the national critical infrastructure? According to the law, we identify several conditions that must be met in terms of the vocation of an element, system or component thereof to be identified as a potential national critical ...
Călin MUNTEAN +2 more
doaj +2 more sources
An ice-sheet scale comparison of eskers with modelled subglacial drainage routes [PDF]
, 2015 Eskers record the signature of channelised meltwater drainage during deglaciation providing vital information on the nature and evolution of subglacial drainage.
Stokes, C.R. +23 more
core +1 more source
FEBS Open Bio, EarlyView.TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose +9 more
wiley +1 more source
FEBS Open Bio, EarlyView.KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph +7 more
wiley +1 more source
EAI Endorsed Transactions on Energy Web, 2017 A distributed system of protection and diagnostics of support structural elements of high-voltage power lines (HVPL) on 500 kV voltage was developed at Karaganda State technical university: - current monitoring of leakage currents of bunches of ...
Vladimir V. Kaverin +3 more
doaj +1 more source
An Ice Protection System Based on Phased Piezoelectric Transducers
ActuatorsThis study focuses on a system constituted of two piezoelectric transducers installed on a slat representative element, with ice protection purposes. The waves generated by these actuators can cause, in fact, shear actions between the slat panel and the ...
Salvatore Ameduri +3 more
doaj +1 more source
Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells
FEBS Open Bio, EarlyView.Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla +10 more
wiley +1 more source
A Study of the Effects of Altitude on Thermal Ice Protection System Performance [PDF]
, 2013 Thermal ice protection systems use heat energy to prevent a dangerous buildup of ice on an aircraft. As aircraft become more efficient, less heat energy is available to operate a thermal ice protections system.
Addy, Gene +3 more
core +2 more sources
FEBS Open Bio, EarlyView.TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao +10 more
wiley +1 more source