Results 101 to 110 of about 885,927 (289)
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Journal of Ocean Engineering and ScienceDifferent from the existing CFD-DEM models in which the ship remains stationary, a CFD-DEM model with the ship in forward motion is proposed in this paper to simulate the process of a ship sailing across pack ice area at a forward speed under different ...
Ming Zou +5 more
doaj +1 more source
International Journal of Naval Architecture and Ocean Engineering, 2019 In this paper, a Smoothed Particle Hydrodynamics (SPH) method is extended to simulate the ice failure process and ice-ship interactions. The softening elastoplastic model integrating Drucker-Prager yield criterion is embedded into the SPH method to ...
Ningbo Zhang +3 more
doaj +1 more source
Impact resistance of composite fan blades [PDF]
The resistance of current-design Pratt and Whitney Aircraft low aspect ratio advanced fiber reinforced epoxy matrix composite fan blades to foreign object damage (FOD) at STOL operating conditions was investigated.
Premont, E. J., Stubenrauch, K. R.
core +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
MicromachinesThis study details the development and validation of a graphene-based ice detection system, designed to enhance flight safety by monitoring ice accumulation on aircraft surfaces.
Dario Farina +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Intensification of the freeze drying process by the control of both freezing and primary drying steps [PDF]
, 2013 The problem of optimization of freeze-drying cycles is addressed, with emphasis in both freezing and primary drying steps. In particular, this study shows that the control of the nucleation event produces more uniform batches (as ice nucleation is ...
Barresi, Antonello +3 more
core
FEBS Open Bio, EarlyView.Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu +5 more
wiley +1 more source
Impact resistance of spar-shell composite fan blades [PDF]
Composite spar-shell fan blades for a 1.83 meter (6 feet) diameter fan stage were fabricated and tested in a whirling arm facility to evaluate foreign object damage (FOD) resistance.
Graff, J., Stoltze, L., Varholak, E. M.
core +1 more source