Results 111 to 120 of about 885,927 (289)

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

Research on Optimization Design of Ice-Class Ship Form Based on Actual Sea Conditions

Journal of Marine Science and Engineering
With the natural evolution of the Arctic route and advancements in related technologies, the development of new green ice-class ships is becoming a key technological breakthrough for the global shipbuilding industry.
Yu Lu, Xuan Cao, Jiafeng Wu, Xiaoxuan Peng, Lin An, Shizhe Liu   +5 more
doaj   +1 more source

Laboratory Measurements of the Resistivity of Ice [PDF]

Journal of Glaciology, 1967
An attempt has been made to measure the D.C. resistivity of ice directly by placing plane–parallel samples between two electrodes with guard rings. Very strong polarization effects were observed which were most pronounced in ice from an ice–cored moraine, lesser in glacier ice, and the least in artificially frozen ice.
openaire   +1 more source

Nondestructive measurement of capillary tube internal diameter [PDF]

, 1975
Technique provides nondestructive method of making quick, accurate determination by measuring electrical resistance of capillary tube when it is filled with electrolyte of known conductivity.
Ho, W. W., Love, A. W., Vanmelle, M. J.
core   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Experimental Investigation on IceBreaking Resistance and Ice Load Distribution for Comparison of Icebreaker Bows

Journal of Marine Science and Engineering
During icebreaker navigation in ice-covered waters, icebreaking resistance and dynamic ice loads acting on the bow critically determine the vessel’s icebreaking performance.
Xuhao Gang, Yukui Tian, Chaoge Yu, Ying Kou, Weihang Zhao   +4 more
doaj   +1 more source

Frozen Soil Lateral Resistance for the Seismic Design of Highway Bridge Foundations [PDF]

, 2012
INE/AUTC 12 ...
Ge, Xiaoxuan, Paris, Anthony, Still, Benjamin, Yang, Zhaohui “Joey”   +3 more
core  

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Immune‐Driven Expression in Inclusion Body Myositis With T‐Cell Large Granular Lymphocytic Leukemia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives T‐cell large granular lymphocytic leukemia (T‐LGLL), reported in up to 58% of inclusion body myositis (IBM) patients, is a rare leukemia of cytotoxic or less commonly helper T cells. The range of myopathies in T‐LGLL and the impact of coexisting T‐LGLL in IBM are not well understood. Our objectives are to investigate the spectrum of
Pannathat Soontrapa, Iago Pinal‐Fernandez, Pritikanta Paul, Michael P. Skolka, Margherita Milone, Min Shi, Mithun V. Shah, Maria Casal‐Dominguez, Katherine Pak, Andrew L. Mammen, Teerin Liewluck   +10 more
wiley   +1 more source