Results 41 to 50 of about 885,927 (289)

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Numerical Research on Hull–Propeller–Rudder–Ice Interaction of Full-Scale Polar Transport Ship in Brash Ice Channel

Journal of Marine Science and Engineering
A strong nonlinear ice load has a significant impact on the resistance and power demand of polar transport ships under different drafts in brash ice channels.
Jinlong Zhang, Jianing Zhang, Lei Zhang, Weimin Chen, Qingshan Zhang   +4 more
doaj   +1 more source

Development of the ice resistance series chart for icebreaking ships

International Journal of Naval Architecture and Ocean Engineering, 2018
The ice resistance series charts for icebreaking ships were developed through a series of systematic model tests in the ice tank of the Korean Research Institute of Ship and Ocean Engineering (KRISO).
Chun-Ju Lee, Tae-Hwan Joung, Jae-Moon Lew   +2 more
doaj   +1 more source

Scale-dependence of lithological control on topography: Bedrock channel geometry and catchment morphometry in western Scotland [PDF]

, 2010
We propose that a scale-dependent topographic signature of erodibility arises due to fluvial and glacial erosion acting on different parts of the landscape at different times.
Bishop, P., Codilean, A.T., Hoey, T.B., Jansen, J.D.   +3 more
core   +3 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Numerical Simulation of Ship Resistance and Ice Load Distribution in Pack Ice

Polish Maritime Research
With global warming enhancing the navigability of Arctic routes, the accurate prediction of ice resistance during navigation is of great engineering significance for the design and performance evaluation of polar ships.
Mei Bin, Ye Jiayun, Zhang Yujia, Zhao Congcong, Shi Guoyou   +4 more
doaj   +1 more source

Numerical simulation of ice resistance of ship turning in level ice zone considering fluid effects

Zhongguo Jianchuan Yanjiu, 2020
Objectives When polar ships sailing in polar regions, extremely complex ice resistance not only poses structural threats to ships, but also poses new challenges for ship maneuverability, especially when the ship is turning in a level ice zone.
NI Baoyu, HUANG Qi, CHEN Wanshou, XUE Yanzhuo   +3 more
doaj   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Prediction of vertical bearing capacity of waveform micropile [PDF]

, 2019
This study proposes a predictive equation for bearing capacity considering the behaviour characteristics of a waveform micropile that can enhance the bearing capacity of a conventional micropile.
Han, J.-T., Jang, Y.-E., Kim, Byungmin, Wang, C   +3 more
core   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source