Results 61 to 70 of about 885,927 (289)

A Review of Computational Simulation Methods for a Ship Advancing in Broken Ice

Journal of Marine Science and Engineering, 2022
Apart from breaking level ice, polar ships can interact with broken ice in various scenarios. In recent years, computational simulation models have increasingly been used for the evaluation of ship operability under broken ice conditions, presenting some
Fang Li, Luofeng Huang
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

GPU Modeling of Ship Operations in Pack Ice [PDF]

, 2012
The paper explores the use of an event-mechanics approach to assess vessel performance in pack ice. The methodology is developed using massively parallel programming strategies on a GPU enabled workstation.
Alawneh, Shadi G., Daley, Claude, Peters, Dennis, Quinton, Bruce   +3 more
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

A prediction method of ice breaking resistance using a multiple regression analysis

International Journal of Naval Architecture and Ocean Engineering, 2015
The two most important tasks of icebreakers are first to secure a sailing route by breaking the thick sea ice and second to sail efficiently herself for purposes of exploration and transportation in the polar seas.
Seong-Rak Cho, Sungsu Lee
doaj   +1 more source

Damage Assessment in Glass Fiber-Epoxy Matrix Composite under High Velocity Impact of Ice [PDF]

Journal of Ultrafine Grained and Nanostructured Materials, 2013
This study investigated the influence of nanoclay on the impact damage resistance of glass fiber-epoxy composites under high velocity ice impact loading. Addition of 0.5 wt.
Shokoofeh Dolati, Abdolhosein Fereidoon, Ali Sabet   +2 more
doaj   +1 more source

Surface Engineering for Phase Change Heat Transfer: A Review [PDF]

, 2014
Among numerous challenges to meet the rising global energy demand in a sustainable manner, improving phase change heat transfer has been at the forefront of engineering research for decades.
Attinger, Daniel, Betz, Amy R., Das, Arindam, Frankiewicz, Christophe, Ganguly, Ranjan, Kim, C. -J., Megaridis, Constantine M., Schutzius, Thomas M.   +7 more
core   +4 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Efficient ship hull multi-objective optimization method considering ice resistance and calm water resistance

Zhongguo Jianchuan Yanjiu
ObjectiveTo address the impact of ice-covered environments on ship performance and the limitations of traditional optimization methods based on empirical formulas for ice resistance, a precise ship design optimization method based on CFD & DEM is ...
Shichao WANG, Gang LIU
doaj   +1 more source